C9WCH8 · C9WCH8_9RHAB
- ProteinNucleoprotein
- GeneN
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids391 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Encapsidates the genome, protecting it from nucleases. If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA. Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation. The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication. Protein N binds protein P in the NC through a different interaction, and can be phosphorylated. Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases.
Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | helical viral capsid | |
Cellular Component | host cell cytoplasm | |
Cellular Component | ribonucleoprotein complex | |
Cellular Component | viral nucleocapsid | |
Molecular Function | RNA binding |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameNucleoprotein
- Short namesNP ; Protein N
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Rhabdoviridae > Gammarhabdovirinae > Novirhabdovirus > Novirhabdovirus salmonid
Accessions
- Primary accessionC9WCH8
Subcellular Location
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 346-391 | Disordered | ||||
Sequence: GSTGEGASELIRRAEMASRGPDMGEEEEEDEEDDYSSEPGDSDSFR | ||||||
Compositional bias | 367-383 | Acidic residues | ||||
Sequence: DMGEEEEEDEEDDYSSE |
Sequence similarities
Belongs to the novirhabdovirus nucleocapsid protein family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length391
- Mass (Da)42,310
- Last updated2009-11-24 v1
- Checksum88FF0C5E2E03D32B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 367-383 | Acidic residues | ||||
Sequence: DMGEEEEEDEEDDYSSE |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FJ265711 EMBL· GenBank· DDBJ | ACO95134.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KX860117 EMBL· GenBank· DDBJ | AOS51180.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KX860118 EMBL· GenBank· DDBJ | AOS51186.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KX860119 EMBL· GenBank· DDBJ | AOS51187.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KX860120 EMBL· GenBank· DDBJ | AOS51192.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KX860121 EMBL· GenBank· DDBJ | AOS51197.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KX860122 EMBL· GenBank· DDBJ | AOS51199.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
LT627082 EMBL· GenBank· DDBJ | SCW25634.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
LT627085 EMBL· GenBank· DDBJ | SCW25637.1 EMBL· GenBank· DDBJ | Viral cRNA |