C9WCH8 · C9WCH8_9RHAB

Function

function

Encapsidates the genome, protecting it from nucleases. If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA. Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation. The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication. Protein N binds protein P in the NC through a different interaction, and can be phosphorylated. Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases.
Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componenthelical viral capsid
Cellular Componenthost cell cytoplasm
Cellular Componentribonucleoprotein complex
Cellular Componentviral nucleocapsid
Molecular FunctionRNA binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nucleoprotein
  • Short names
    NP
    ; Protein N
  • Alternative names
    • Nucleocapsid protein

Gene names

    • Name
      N

Organism names

  • Taxonomic identifier
  • Strains
    • FR-32/87
    • IHNVN1G2
    • IHNVN1G3
    • IHNVN2G3
    • IHNVN2G4
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Rhabdoviridae > Gammarhabdovirinae > Novirhabdovirus > Novirhabdovirus salmonid

Accessions

  • Primary accession
    C9WCH8

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA.

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region346-391Disordered
Compositional bias367-383Acidic residues

Sequence similarities

Belongs to the novirhabdovirus nucleocapsid protein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    391
  • Mass (Da)
    42,310
  • Last updated
    2009-11-24 v1
  • Checksum
    88FF0C5E2E03D32B
MTSALRETFTGLRDIKGGVLEDAETEYRPGTITLPLFFSKTDFDLEMIKRAVSQVGGEGTRRALGLLCAFVIAETVPSEAGTVAELLEALGFVLESLDTGAPPDATFADPNNKLAETIVKENVLEVVTGLLFTCALLTKYDVDKMATYCQNKLERLATSQGIGELVNFNANRGVLARIGSVLRPGQKLTKAIYGIILINLSDPAIAARAKALCAMRLSGTGMTMVGLFNQAAKNLGALPADLLEDLCMKSVVESARRIVRLMRIVAEAPGVAAKYGIMMSRMLGEGYFKAYGINENARITCILMNINDRYDDGTSRGLTGIKVSDPFRKLAREIARLLVLKYDGDGSTGEGASELIRRAEMASRGPDMGEEEEEDEEDDYSSEPGDSDSFR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias367-383Acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJ265711
EMBL· GenBank· DDBJ
ACO95134.1
EMBL· GenBank· DDBJ
Viral cRNA
KX860117
EMBL· GenBank· DDBJ
AOS51180.1
EMBL· GenBank· DDBJ
Viral cRNA
KX860118
EMBL· GenBank· DDBJ
AOS51186.1
EMBL· GenBank· DDBJ
Viral cRNA
KX860119
EMBL· GenBank· DDBJ
AOS51187.1
EMBL· GenBank· DDBJ
Viral cRNA
KX860120
EMBL· GenBank· DDBJ
AOS51192.1
EMBL· GenBank· DDBJ
Viral cRNA
KX860121
EMBL· GenBank· DDBJ
AOS51197.1
EMBL· GenBank· DDBJ
Viral cRNA
KX860122
EMBL· GenBank· DDBJ
AOS51199.1
EMBL· GenBank· DDBJ
Viral cRNA
LT627082
EMBL· GenBank· DDBJ
SCW25634.1
EMBL· GenBank· DDBJ
Viral cRNA
LT627085
EMBL· GenBank· DDBJ
SCW25637.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

Disclaimer

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