C9S7Z6 · GFA_VERA1

Function

function

Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (glutathione route): step 1/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site27Zn2+ 1 (UniProtKB | ChEBI); structural
Binding site29Zn2+ 1 (UniProtKB | ChEBI); structural
Binding site48Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site50Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site53Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site95Zn2+ 1 (UniProtKB | ChEBI); structural
Binding site98Zn2+ 1 (UniProtKB | ChEBI); structural

GO annotations

AspectTerm
Molecular FunctionS-(hydroxymethyl)glutathione synthase activity
Molecular Functionzinc ion binding
Biological Processformaldehyde catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Putative glutathione-dependent formaldehyde-activating enzyme
  • EC number
  • Alternative names
    • S-(hydroxymethyl)glutathione synthase

Gene names

    • ORF names
      VDBG_01395

Organism names

Accessions

  • Primary accession
    C9S7Z6

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004061671-187Putative glutathione-dependent formaldehyde-activating enzyme

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-166CENP-V/GFA

Sequence similarities

Belongs to the Gfa family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    187
  • Mass (Da)
    20,053
  • Last updated
    2009-11-24 v1
  • Checksum
    CDE668FDEBB6D3F6
MSFPLHPSLVNGITKGNPSFQGGVLKCKCSTSPVTVTLRSNVAHNHACGCSKCWKPEGALFSIVSVVPVDKLEVTANGDKLAVVDPSATILRHACTGCGVHLYGRIEKDHAFKGLDFVHTELSDEKGWQEPQFAGFVTSIIEQGFDARHIDDVRAQFESLGLESYDALNPPLMNAIAAFTAANEAKA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS985214
EMBL· GenBank· DDBJ
EEY15286.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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