C9RPJ7 · C9RPJ7_FIBSS

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site73substrate
Binding site217-219substrate
Binding site226Mn2+ (UniProtKB | ChEBI)
Binding site246Mn2+ (UniProtKB | ChEBI)
Binding site268substrate
Binding site269-274GTP (UniProtKB | ChEBI)
Active site270
Binding site293Mn2+ (UniProtKB | ChEBI)
Binding site389-391substrate
Binding site391GTP (UniProtKB | ChEBI)
Binding site422GTP (UniProtKB | ChEBI)
Binding site525-528GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processphosphorylation
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • Ordered locus names
      FSU_0213

Organism names

Accessions

  • Primary accession
    C9RPJ7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain16-238Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain242-615Phosphoenolpyruvate carboxykinase C-terminal P-loop

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    620
  • Mass (Da)
    68,982
  • Last updated
    2009-11-24 v1
  • Checksum
    027162F990B84455
MSLTLNDIKHPKISTWVNEMIAMCEPDNVVVVDGTQEEYDALMQKCVKAGLATKLAKKENCYLFRSLPSDVARVESRTFISSVKEEDAGPTNHWIDPSELKQTMRKLYKGCMHGRTMYVIPFCMGPLGSPISKNGIEVTDSEYVVLNMDIMTRAGKKVLDIFNADVNAEFVPCLHSVGKPLRECESDNGIWPCADVEYKYITQFPEERLIWSYGSGYGGNALLGKKCFALRIATVLARDEGWLAEHMLILKLTNPKGEVKYVTGAFPSACGKTNLAMLIPTIPGWKVETIGDDIAWMKFGKDGRLYAINPEAGFFGVAPGTSAESNKNALVSAEKNTIYTNCALTEDGDVWWEGIGYPAQGKLVDWKGKTRDALPKDKAPKGEEMAHPNARFTAPAKQCPCIAKEWEDPAGVPISAILFGGRRPSTIPLVHQSLSWNHGVFLGSIVGSEITAASTIDASQVGKIRRDPFAILPFCGYNMGDYFKHWIEIGQKSTEDKLPKIFYVNWFRKDANNEKLPGGFMWPGYGDNSRVLAWIFDRCNGVDNAVETPIGYMPKEGAINTDGLADYYKETLPQITKVDVEGWKKELADVKENHYPKFGKHLPKELSEIIDMIQDRLNKA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002158
EMBL· GenBank· DDBJ
ADL26479.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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