C9K1W9 · C9K1W9_CANBO

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ per subunit.
thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Features

Showing features for binding site.

156950100150200250300350400450500550
TypeIDPosition(s)Description
Binding site29pyruvate 1 (UniProtKB | ChEBI); substrate; ligand shared between two neighboring subunits
Binding site116pyruvate 1 (UniProtKB | ChEBI); substrate; ligand shared between two neighboring subunits
Binding site158pyruvate 2 (UniProtKB | ChEBI); allosteric activator
Binding site449Mg2+ (UniProtKB | ChEBI)
Binding site476Mg2+ (UniProtKB | ChEBI)
Binding site478Mg2+ (UniProtKB | ChEBI)
Binding site482pyruvate 1 (UniProtKB | ChEBI); substrate; ligand shared between two neighboring subunits

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functionmagnesium ion binding
Molecular Functionpyruvate decarboxylase activity
Molecular Functionthiamine pyrophosphate binding
Biological Processaromatic amino acid family catabolic process to alcohol via Ehrlich pathway

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Pyruvate decarboxylase

Gene names

    • Name
      PDC1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Pichiaceae > Ogataea > Ogataea/Candida clade

Accessions

  • Primary accession
    C9K1W9

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-115Thiamine pyrophosphate enzyme N-terminal TPP-binding
Domain203-328Thiamine pyrophosphate enzyme central
Domain406-485Thiamine pyrophosphate enzyme TPP-binding

Sequence similarities

Belongs to the TPP enzyme family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    569
  • Mass (Da)
    63,232
  • Last updated
    2009-11-24 v1
  • Checksum
    EBCBC07453D0274D
MSPQIPLGRYFFERMNQLDVNTIFGVPGDFNLALLDHIYEVEGMRWAGNANELNAAYAADGYSRIKGLSCLITTFGVGELSALNGVAGAFAEHVGMVHLVGVPSISATEKRLLLHHTLGNGDFHAFREMSKQISKDTLYIDNINYACEEIDRIITEAYVYKRPVYIALPTNFVEMKVDANRLKTPLETAPPLNEPAAEDEVVDAIKDIIKAAKKPIILVDACALRHDSTKAVHELSNITQFPVFTTPMGKSSVDESHPRFGGVYVGVLSQPDVKEVVESSDLILSIGGLLSDFNTGSFSYDYHTSNVIEFHSDYTKIRKAVYQDVKMPYVVERLVNELTTGGGIQGYVPTPIPKSVTDYKQAALTTSGKITQEWWWKRVSTFFRPGDIIISETGTSAFGITQSHFPTQAIGISQVLWGSIGFTVGACLGAVMGAEEKYPDRRVILFVGDGSLQLTVQEISTMCRWKLNPYLFVLNNSGYTIEKLIHGPTAQYNEIQLWDHSKMLPLFHGDHVYENYRLDSVEVANKYLEDPEFNTPNKIRMVELMLDVMDAPSNLVQQAAFSAKTNAEN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB440630
EMBL· GenBank· DDBJ
BAI43440.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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