C9K1W9 · C9K1W9_CANBO
- ProteinPyruvate decarboxylase
- GenePDC1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids569 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- H+ + pyruvate = acetaldehyde + CO2
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Mg2+ per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 29 | pyruvate 1 (UniProtKB | ChEBI); substrate; ligand shared between two neighboring subunits | ||||
Sequence: D | ||||||
Binding site | 116 | pyruvate 1 (UniProtKB | ChEBI); substrate; ligand shared between two neighboring subunits | ||||
Sequence: H | ||||||
Binding site | 158 | pyruvate 2 (UniProtKB | ChEBI); allosteric activator | ||||
Sequence: Y | ||||||
Binding site | 449 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 476 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 478 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 482 | pyruvate 1 (UniProtKB | ChEBI); substrate; ligand shared between two neighboring subunits | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | magnesium ion binding | |
Molecular Function | pyruvate decarboxylase activity | |
Molecular Function | thiamine pyrophosphate binding | |
Biological Process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Pichiaceae > Ogataea > Ogataea/Candida clade
Accessions
- Primary accessionC9K1W9
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-115 | Thiamine pyrophosphate enzyme N-terminal TPP-binding | ||||
Sequence: LGRYFFERMNQLDVNTIFGVPGDFNLALLDHIYEVEGMRWAGNANELNAAYAADGYSRIKGLSCLITTFGVGELSALNGVAGAFAEHVGMVHLVGVPSISATEKRLLLH | ||||||
Domain | 203-328 | Thiamine pyrophosphate enzyme central | ||||
Sequence: DAIKDIIKAAKKPIILVDACALRHDSTKAVHELSNITQFPVFTTPMGKSSVDESHPRFGGVYVGVLSQPDVKEVVESSDLILSIGGLLSDFNTGSFSYDYHTSNVIEFHSDYTKIRKAVYQDVKMP | ||||||
Domain | 406-485 | Thiamine pyrophosphate enzyme TPP-binding | ||||
Sequence: PTQAIGISQVLWGSIGFTVGACLGAVMGAEEKYPDRRVILFVGDGSLQLTVQEISTMCRWKLNPYLFVLNNSGYTIEKLI |
Sequence similarities
Belongs to the TPP enzyme family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length569
- Mass (Da)63,232
- Last updated2009-11-24 v1
- ChecksumEBCBC07453D0274D