C9JWG1 · C9JWG1_HUMAN
- ProteinVery-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
- GeneHACD2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Catalytic activity
- (3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2OThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism; fatty acid biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity | |
Biological Process | fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameVery-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionC9JWG1
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 23-46 | Helical | |||
Transmembrane | 58-80 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusFragment
- Length98
- Mass (Da)11,412
- Last updated2009-11-03 v1
- MD5 Checksum186D1DD13740959AF4752A60E23E279C
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 98 | ||||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC020631 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC023165 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC025571 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC084039 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |