C9D7C8 · C9D7C8_TRICA
- ProteinSodium channel protein
- GenePARA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2048 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | voltage-gated sodium channel complex | |
Molecular Function | calcium ion binding | |
Molecular Function | voltage-gated sodium channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSodium channel protein
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Tenebrionidae > Tenebrionidae incertae sedis > Tribolium
Accessions
- Primary accessionC9D7C8
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 144-171 | Helical | ||||
Sequence: VAIYILVHPLFSLFIITTILVNCILMIM | ||||||
Transmembrane | 215-237 | Helical | ||||
Sequence: WLDFVVIALAYVTMGIDLGNLAA | ||||||
Transmembrane | 249-267 | Helical | ||||
Sequence: TVAIVPGLKTIVGAVIESV | ||||||
Transmembrane | 273-295 | Helical | ||||
Sequence: VIILTMFSLSVFALIGLQIYMGV | ||||||
Transmembrane | 406-431 | Helical | ||||
Sequence: LFFIVIIFLGSFYLVNLILAIVAMSY | ||||||
Transmembrane | 796-820 | Helical | ||||
Sequence: FVALLVFDPFVELFITLCIVVNTLF | ||||||
Transmembrane | 841-858 | Helical | ||||
Sequence: YFFTATFMIEATLKLIAM | ||||||
Transmembrane | 870-894 | Helical | ||||
Sequence: IFDFIIVALSLLELGLEGVQGLSVL | ||||||
Transmembrane | 925-947 | Helical | ||||
Sequence: ALGNLTFVLCIIIFIFAVMGMQL | ||||||
Transmembrane | 1005-1026 | Helical | ||||
Sequence: FFLATVVIGNLVVLNLFLALLL | ||||||
Transmembrane | 1326-1345 | Helical | ||||
Sequence: IFTVIFFFEMLIKWLALGFQ | ||||||
Transmembrane | 1357-1380 | Helical | ||||
Sequence: FVIVMVSLINFIASLCGAGGIQAF | ||||||
Transmembrane | 1401-1432 | Helical | ||||
Sequence: MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIM | ||||||
Transmembrane | 1519-1545 | Helical | ||||
Sequence: IYMYLYFVFFIIFGSFFTLNLFIGVII | ||||||
Transmembrane | 1608-1626 | Helical | ||||
Sequence: MIIMLFIGLNMLTMTMDHY | ||||||
Transmembrane | 1638-1657 | Helical | ||||
Sequence: SLNMIFIVIFSTECLMKIFA | ||||||
Transmembrane | 1669-1688 | Helical | ||||
Sequence: LFDLVVVILSILGLVLSDII | ||||||
Transmembrane | 1732-1755 | Helical | ||||
Sequence: ALFNICLLLFLVMFIFAIFGMSFF | ||||||
Transmembrane | 1822-1845 | Helical | ||||
Sequence: IAFLLSYLVISFLIVINMYIAVIL |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for compositional bias, region, coiled coil, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 37-65 | Basic and acidic residues | ||||
Sequence: KQKELEKKRAEGETGFGRRKKKKDIRYED | ||||||
Region | 37-83 | Disordered | ||||
Sequence: KQKELEKKRAEGETGFGRRKKKKDIRYEDEDEDEGPQPDPTLEQGLP | ||||||
Coiled coil | 431-462 | |||||
Sequence: YDELQKKAQDEEEAEANAIREAEQKAKDKQDR | ||||||
Compositional bias | 1182-1209 | Basic and acidic residues | ||||
Sequence: RFKEESHKGSVDMLDDHEEKRDASKEEL | ||||||
Region | 1182-1218 | Disordered | ||||
Sequence: RFKEESHKGSVDMLDDHEEKRDASKEELGIGEEETED | ||||||
Domain | 1862-1897 | EF-hand | ||||
Sequence: DDYDMYYEIWQQFDPDGTQYIRYDQLSDLFDVLEPP |
Sequence similarities
Belongs to the sodium channel (TC 1.A.1.10) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,048
- Mass (Da)231,970
- Last updated2009-11-03 v1
- ChecksumF5738C9D82BE6651
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 37-65 | Basic and acidic residues | ||||
Sequence: KQKELEKKRAEGETGFGRRKKKKDIRYED | ||||||
Compositional bias | 1182-1209 | Basic and acidic residues | ||||
Sequence: RFKEESHKGSVDMLDDHEEKRDASKEEL |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GQ202025 EMBL· GenBank· DDBJ | ACV87003.1 EMBL· GenBank· DDBJ | mRNA |