C9D7C8 · C9D7C8_TRICA

Function

function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentvoltage-gated sodium channel complex
Molecular Functioncalcium ion binding
Molecular Functionvoltage-gated sodium channel activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sodium channel protein

Gene names

    • Name
      PARA

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Tenebrionidae > Tenebrionidae incertae sedis > Tribolium

Accessions

  • Primary accession
    C9D7C8

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane144-171Helical
Transmembrane215-237Helical
Transmembrane249-267Helical
Transmembrane273-295Helical
Transmembrane406-431Helical
Transmembrane796-820Helical
Transmembrane841-858Helical
Transmembrane870-894Helical
Transmembrane925-947Helical
Transmembrane1005-1026Helical
Transmembrane1326-1345Helical
Transmembrane1357-1380Helical
Transmembrane1401-1432Helical
Transmembrane1519-1545Helical
Transmembrane1608-1626Helical
Transmembrane1638-1657Helical
Transmembrane1669-1688Helical
Transmembrane1732-1755Helical
Transmembrane1822-1845Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for compositional bias, region, coiled coil, domain.

TypeIDPosition(s)Description
Compositional bias37-65Basic and acidic residues
Region37-83Disordered
Coiled coil431-462
Compositional bias1182-1209Basic and acidic residues
Region1182-1218Disordered
Domain1862-1897EF-hand

Sequence similarities

Belongs to the sodium channel (TC 1.A.1.10) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,048
  • Mass (Da)
    231,970
  • Last updated
    2009-11-03 v1
  • Checksum
    F5738C9D82BE6651
MSVASDYSSEEELSLFRPFTRESLAVIETRIAEEYAKQKELEKKRAEGETGFGRRKKKKDIRYEDEDEDEGPQPDPTLEQGLPLPVRLHSTFPPELASTPLEDIDPFYSNQRTFVVVSKGKDIFRFSATNALWVLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALIGLQIYMGVLTQKCIKEFPLDGSWGNLTHENWERFVSNESNWYWDDEKGERPLCGNSSGSGMCKEGYVCLQGYGDNPNYGYTSFDTFGWALLSAFRLMTQDYWENLYQLVLRSAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAQDEEEAEANAIREAEQKAKDKQDRADARAAAAVEAAEAAAAAAAAAAAGCDNDQYIIKSSSDYSCHSYESFVGQPNGQDDNNKEKISIRSEGLDSVSEQRRVPTNLSKMRKVSAASLSLPGSPFNLRRGSRGSHQFTLRNNRRMVAPPGDRKPLVLSTYLDAQEHLPYADDSNAVTPMSEENGVMVLPMYYTNLGSRHSSYTSHASRMSYTSHGDLLGGLGSNGKMMTKESQLRNRSLRNGPAAAPLNHKSTRGVYDGPTGHICESKVKQIDNPFIDSNQRQTVVDMKDVMVLNDIIEQAAVSGGSDRGVSVYYFSANNDDEEEEPTFRERFLAYAIKIIDMFCVWDCCKCWVVIQKFVALLVFDPFVELFITLCIVVNTLFMALDHHDMDKDLEKALKSGNYFFTATFMIEATLKLIAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYTDNVDRFPDHELPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFDRIGRFIRWIKGNVLHIAKLVRFKLTNQISDQPSGEGPSNSWNQDVRCDGGLDISGDEILADGIIKKSPKDRLEVTIGTGMDLTVHGDPKRGKNNINKSKTIGNSILEHGMYIGHLDEDEISNKSYGSHKNRFKEESHKGSVDMLDDHEEKRDASKEELGIGEEETEDDRFDLEKPLTDIVIVGNADDIIIDDYAADCFPDSCYKKFPFLAGDEDSPFWQGWGNLRSKTYRLIENKYFETAVITMILLSSMALALEDVHLQSRPILQDILYYMDRIFTVIFFFEMLIKWLALGFQKYFTNAWCWLDFVIVMVSLINFIASLCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDANKTTLSYEIIPDVNACKAENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSRDINKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKGGDSLALMMTDAQKKYYNAMKKMGSKKPMKAIPRPRWRPQAIVFEIVTNKKFDMIIMLFIGLNMLTMTMDHYQQKETFTKVLDSLNMIFIVIFSTECLMKIFALRYHYFTEPWNLFDLVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKSGLDDVYNFKTFGQSMILLFQMSTSAGWDGVLDGIINEEDCKPPNSEIGETGNCGNSTIGIAFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPDGTQYIRYDQLSDLFDVLEPPLQIHKPNKFKIYSMDIPICKGDMMFCVDILDALTKDFFARKGNEIEETAELSEVQPRQNEPGYEQVSSTLYRQREEYCARLIQNAWRKYRQRTGGAPEQVNVDGAAGEGDGEVEVHQTAVLVESDGFVTKNGHKVVLHSRTPSISSKSADV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias37-65Basic and acidic residues
Compositional bias1182-1209Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ202025
EMBL· GenBank· DDBJ
ACV87003.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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