C9D7C6 · C9D7C6_BOMMO

  • Protein
    Sodium channel protein
  • Gene
    PARA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentvoltage-gated sodium channel complex
Molecular Functioncalcium ion binding
Molecular Functionvoltage-gated sodium channel activity
Biological Processmembrane depolarization during action potential
Biological Processneuronal action potential

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sodium channel protein

Gene names

    • Name
      PARA

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Bombycoidea > Bombycidae > Bombycinae > Bombyx

Accessions

  • Primary accession
    C9D7C6

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane133-159Helical
Transmembrane171-192Helical
Transmembrane204-226Helical
Transmembrane232-253Helical
Transmembrane262-282Helical
Transmembrane392-414Helical
Transmembrane799-822Helical
Transmembrane843-860Helical
Transmembrane872-896Helical
Transmembrane927-949Helical
Transmembrane969-986Helical
Transmembrane1007-1028Helical
Transmembrane1287-1306Helical
Transmembrane1327-1346Helical
Transmembrane1358-1381Helical
Transmembrane1402-1433Helical
Transmembrane1520-1546Helical
Transmembrane1609-1627Helical
Transmembrane1639-1658Helical
Transmembrane1670-1689Helical
Transmembrane1733-1756Helical
Transmembrane1826-1846Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias36-51Basic and acidic residues
Region36-69Disordered
Compositional bias429-460Basic and acidic residues
Region429-578Disordered
Compositional bias478-495Polar residues
Compositional bias510-526Polar residues
Region640-686Disordered
Compositional bias662-677Polar residues
Region1162-1209Disordered
Compositional bias1173-1209Basic and acidic residues
Domain1863-1898EF-hand
Region2019-2038Disordered

Sequence similarities

Belongs to the sodium channel (TC 1.A.1.10) family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,038
  • Mass (Da)
    230,985
  • Last updated
    2009-11-03 v1
  • Checksum
    C08FC69A66AE88AE
MSEDLDSISEEERSLFRPFTRESLAAIEARIAEEHAKQKELEKKRAEGEVRYDDEDEDEGPQPDATLEQGLPLPVRMQGSFPLELASTPLEDIDPFYHNQTTFVVISKGKDIFRFSATNALWILDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEVIFTGIYTFESAVKVMARGFILQPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALNTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCVKVFPEDGSWGNLTDENWERFCQNETNWYGEGGDYPLCGNSSGAGQCEPGYVCLQGFGPNPNYGYTSFDTFGWAFLSAFRLMTQDYWENLYQLVLRSAGSWHVLFFVVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEQAEEEALREAEQKAAARADKQEAREAHAREQAAAAEAAAYAEAHPAKSPSDFSCQSYELFVNQERGNQDDNTRERMSLRSDPFQDSVSTQPAHKPTATDTHDSARRPRKVSMASLSLPGSPFNLRRGSRGSHQMALRPNGRPRYPPGGDRKPLVLSTYLDAQEHLPYADDSNAVTPMSEENGAIIIPVYYANLGSRHSSYTSHQSRLSYTSHGDLLGGGKAQTKEARLRGRSASRNHSVTSQPHAYPLPRQDSSLASRPLREYEVSTTECTDEAGKVLKPSSDNPFIESSQQPNVVDMRDVMVLNEIIEQAGRQSRASEQNVSVYYFPTAEDDEDGPTFKEKLLDCLMKGIDFFCVWDCCWLWLEFQKYVALLVFDPFVELFITLCIVVNTLFMALDHHNMDKDMDKALKSGNYFFTATFGIEATLKLIAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYVDYVDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMLVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSTPTADQDTNKIAEAFNRISRFIDWIKRNVADFLKLLKNKLTNQIAIHAPERVDNELELGTDLDDAVLYKDKKLKDQVEVAIGDGMEFTIPGDNKYKKGKILMNNINAITDNHRDNRLDCELNHHGYPIQDDDTISQKSYGSHKIRSFKDESHKGSADTIDGEEKKDASKEELGLEEELIEEDEEGKLDGTLGKTDIKVGADEDVVDDTPADCCPEQCYQKFPFLAGDDDSPFWQGWGTLRLKTFKLIENTYFETAVITMILLSSLALALEDVHLPHRPILQDILYYMDRIFTVIFFIEMLIKWLALGFQKYFTNAWCWLDFIIVMVSLINFVAALCGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCVDMNHTTLSHEIIPDKNACTLENYTWENSPMNFDHVGKAYLCLFQVATFKGWIQIMNDAIDSREVGRQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDMIIMLFIGLNMLTMTLDHYQQSETFSAVLDYLNMIFIVIFSSECLLKIFALRYHYFVEPWNLFDFVVVMFSILSLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKDKGGLDDVYNFKTFVQSMILLFQMSTSAGWDGVLDGIINEEECDLPDNERGSPGNCGSATIGITYLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQRFDPDGSQYIRYDQLSDSLDVLEPPLQIHKPNKYKIISMDIPICRGDMMFCVDILDALTKDFFARKGNPIEETGDLEVGRPEEAGYEPVSSTLWRQREEYCARLIQHAWRRHRRAHEEPEVGGGAEGAATAVLLDAVTPNGHRVVLQGGGAAPRPPEPAPPPASV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias36-51Basic and acidic residues
Compositional bias429-460Basic and acidic residues
Compositional bias478-495Polar residues
Compositional bias510-526Polar residues
Compositional bias662-677Polar residues
Compositional bias1173-1209Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ202023
EMBL· GenBank· DDBJ
ACV87001.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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