C9D7C6 · C9D7C6_BOMMO
- ProteinSodium channel protein
- GenePARA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2038 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | voltage-gated sodium channel complex | |
Molecular Function | calcium ion binding | |
Molecular Function | voltage-gated sodium channel activity | |
Biological Process | membrane depolarization during action potential | |
Biological Process | neuronal action potential |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSodium channel protein
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Bombycoidea > Bombycidae > Bombycinae > Bombyx
Accessions
- Primary accessionC9D7C6
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 133-159 | Helical | ||||
Sequence: VAIYILVHPLFSLFIITTILVNCILMI | ||||||
Transmembrane | 171-192 | Helical | ||||
Sequence: VIFTGIYTFESAVKVMARGFIL | ||||||
Transmembrane | 204-226 | Helical | ||||
Sequence: WLDFVVIALAYVTMGIDLGNLAA | ||||||
Transmembrane | 232-253 | Helical | ||||
Sequence: VLRALNTVAIVPGLKTIVGAVI | ||||||
Transmembrane | 262-282 | Helical | ||||
Sequence: VIILTMFSLSVFALMGLQIYM | ||||||
Transmembrane | 392-414 | Helical | ||||
Sequence: VLFFVVIIFLGSFYLVNLILAIV | ||||||
Transmembrane | 799-822 | Helical | ||||
Sequence: VALLVFDPFVELFITLCIVVNTLF | ||||||
Transmembrane | 843-860 | Helical | ||||
Sequence: YFFTATFGIEATLKLIAM | ||||||
Transmembrane | 872-896 | Helical | ||||
Sequence: IFDFIIVALSLLELGLEGVQGLSVL | ||||||
Transmembrane | 927-949 | Helical | ||||
Sequence: ALGNLTFVLCIIIFIFAVMGMQL | ||||||
Transmembrane | 969-986 | Helical | ||||
Sequence: WNFTDFMHSFMIVFRVLC | ||||||
Transmembrane | 1007-1028 | Helical | ||||
Sequence: FFLATVVIGNLVVLNLFLALLL | ||||||
Transmembrane | 1287-1306 | Helical | ||||
Sequence: TYFETAVITMILLSSLALAL | ||||||
Transmembrane | 1327-1346 | Helical | ||||
Sequence: IFTVIFFIEMLIKWLALGFQ | ||||||
Transmembrane | 1358-1381 | Helical | ||||
Sequence: FIIVMVSLINFVAALCGAGGIQAF | ||||||
Transmembrane | 1402-1433 | Helical | ||||
Sequence: MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIM | ||||||
Transmembrane | 1520-1546 | Helical | ||||
Sequence: IYMYLYFVFFIIFGSFFTLNLFIGVII | ||||||
Transmembrane | 1609-1627 | Helical | ||||
Sequence: MIIMLFIGLNMLTMTLDHY | ||||||
Transmembrane | 1639-1658 | Helical | ||||
Sequence: YLNMIFIVIFSSECLLKIFA | ||||||
Transmembrane | 1670-1689 | Helical | ||||
Sequence: LFDFVVVMFSILSLVLSDII | ||||||
Transmembrane | 1733-1756 | Helical | ||||
Sequence: ALFNICLLLFLVMFIFAIFGMSFF | ||||||
Transmembrane | 1826-1846 | Helical | ||||
Sequence: LLSYLVISFLIVINMYIAVIL |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 36-51 | Basic and acidic residues | ||||
Sequence: AKQKELEKKRAEGEVR | ||||||
Region | 36-69 | Disordered | ||||
Sequence: AKQKELEKKRAEGEVRYDDEDEDEGPQPDATLEQ | ||||||
Compositional bias | 429-460 | Basic and acidic residues | ||||
Sequence: EQAEEEALREAEQKAAARADKQEAREAHAREQ | ||||||
Region | 429-578 | Disordered | ||||
Sequence: EQAEEEALREAEQKAAARADKQEAREAHAREQAAAAEAAAYAEAHPAKSPSDFSCQSYELFVNQERGNQDDNTRERMSLRSDPFQDSVSTQPAHKPTATDTHDSARRPRKVSMASLSLPGSPFNLRRGSRGSHQMALRPNGRPRYPPGGD | ||||||
Compositional bias | 478-495 | Polar residues | ||||
Sequence: PSDFSCQSYELFVNQERG | ||||||
Compositional bias | 510-526 | Polar residues | ||||
Sequence: DPFQDSVSTQPAHKPTA | ||||||
Region | 640-686 | Disordered | ||||
Sequence: SHGDLLGGGKAQTKEARLRGRSASRNHSVTSQPHAYPLPRQDSSLAS | ||||||
Compositional bias | 662-677 | Polar residues | ||||
Sequence: ASRNHSVTSQPHAYPL | ||||||
Region | 1162-1209 | Disordered | ||||
Sequence: GYPIQDDDTISQKSYGSHKIRSFKDESHKGSADTIDGEEKKDASKEEL | ||||||
Compositional bias | 1173-1209 | Basic and acidic residues | ||||
Sequence: QKSYGSHKIRSFKDESHKGSADTIDGEEKKDASKEEL | ||||||
Domain | 1863-1898 | EF-hand | ||||
Sequence: DDYDMYYEIWQRFDPDGSQYIRYDQLSDSLDVLEPP | ||||||
Region | 2019-2038 | Disordered | ||||
Sequence: LQGGGAAPRPPEPAPPPASV |
Sequence similarities
Belongs to the sodium channel (TC 1.A.1.10) family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,038
- Mass (Da)230,985
- Last updated2009-11-03 v1
- ChecksumC08FC69A66AE88AE
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 36-51 | Basic and acidic residues | ||||
Sequence: AKQKELEKKRAEGEVR | ||||||
Compositional bias | 429-460 | Basic and acidic residues | ||||
Sequence: EQAEEEALREAEQKAAARADKQEAREAHAREQ | ||||||
Compositional bias | 478-495 | Polar residues | ||||
Sequence: PSDFSCQSYELFVNQERG | ||||||
Compositional bias | 510-526 | Polar residues | ||||
Sequence: DPFQDSVSTQPAHKPTA | ||||||
Compositional bias | 662-677 | Polar residues | ||||
Sequence: ASRNHSVTSQPHAYPL | ||||||
Compositional bias | 1173-1209 | Basic and acidic residues | ||||
Sequence: QKSYGSHKIRSFKDESHKGSADTIDGEEKKDASKEEL |