C9D7C4 · C9D7C4_TRICA
- ProteinVoltage-dependent L-type calcium channel subunit alpha
- GeneCAC
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1727 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | voltage-gated calcium channel complex | |
Molecular Function | calcium ion binding | |
Molecular Function | voltage-gated calcium channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVoltage-dependent L-type calcium channel subunit alpha
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Tenebrionidae > Tenebrionidae incertae sedis > Tribolium
Accessions
- Primary accessionC9D7C4
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 60-77 | Helical | ||||
Sequence: FEYTVILTIIANCVVLAL | ||||||
Transmembrane | 98-119 | Helical | ||||
Sequence: MYFLAIFCAESLLKILALGFVL | ||||||
Transmembrane | 131-151 | Helical | ||||
Sequence: IMDFFVVLTGVLTVLMQDVNL | ||||||
Transmembrane | 186-208 | Helical | ||||
Sequence: LLQIGLLVLFAIVIFAIIGLEFY | ||||||
Transmembrane | 275-296 | Helical | ||||
Sequence: IGYAMLTVFQCITMEGWTPILY | ||||||
Transmembrane | 308-330 | Helical | ||||
Sequence: WMYFVPLIVLGSFFMLNLVLGVL | ||||||
Transmembrane | 456-476 | Helical | ||||
Sequence: WFYWSVIVLVFFNTVCVAVEY | ||||||
Transmembrane | 488-508 | Helical | ||||
Sequence: YYAEFVFLGLFLSEMFVKVYA | ||||||
Transmembrane | 581-603 | Helical | ||||
Sequence: IISLLFLLFLFILIFALLGMQLF | ||||||
Transmembrane | 658-682 | Helical | ||||
Sequence: YSLYFIVLMLFGNYTLLNVFLAIAV | ||||||
Transmembrane | 777-796 | Helical | ||||
Sequence: LRYFDFFIMVVICLSSMALA | ||||||
Transmembrane | 816-837 | Helical | ||||
Sequence: YAFTVVFASEMFLKIIDLGIIL | ||||||
Transmembrane | 849-867 | Helical | ||||
Sequence: FMDATVVICALVSMGFNFA | ||||||
Transmembrane | 913-935 | Helical | ||||
Sequence: VINILIVYILFHFIFAVIAVQLW | ||||||
Transmembrane | 1027-1052 | Helical | ||||
Sequence: IFYIVYFVVFPFFFVNIFVALIIITF | ||||||
Transmembrane | 1108-1126 | Helical | ||||
Sequence: YFIMMLIVFNTLLLMMKYD | ||||||
Transmembrane | 1138-1160 | Helical | ||||
Sequence: YLNWLFTGLFTVECILKIVAYGA | ||||||
Transmembrane | 1229-1247 | Helical | ||||
Sequence: ALPYVCLLIAMLFFIYAII | ||||||
Transmembrane | 1316-1341 | Helical | ||||
Sequence: IAYAYFVSFIFFCSFLMLNLFVAVIM |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 8-31 | Disordered | ||||
Sequence: LAAEQGDQGEQTTNTTKRKKTAPG | ||||||
Compositional bias | 12-29 | Polar residues | ||||
Sequence: QGDQGEQTTNTTKRKKTA | ||||||
Region | 397-428 | Disordered | ||||
Sequence: KKKLKKIGPSKSTDTEDESEMGDDAFGRSARS | ||||||
Coiled coil | 685-720 | |||||
Sequence: LANAQELTAAEEEQAEENREKQAQELEKEMEALQMD | ||||||
Region | 728-749 | Disordered | ||||
Sequence: SPTKETKKKKEEKVEEEEVEGP | ||||||
Compositional bias | 729-749 | Basic and acidic residues | ||||
Sequence: PTKETKKKKEEKVEEEEVEGP | ||||||
Domain | 1357-1392 | EF-hand | ||||
Sequence: HHLDEFIRIWAEYDPKATAKIHYTEMYEMLKNMAPP | ||||||
Compositional bias | 1528-1573 | Polar residues | ||||
Sequence: IESGSDSRRQSSEGTRSQYLDLPNSDHHWSASSTPAHTPFTRNTRH | ||||||
Region | 1528-1652 | Disordered | ||||
Sequence: IESGSDSRRQSSEGTRSQYLDLPNSDHHWSASSTPAHTPFTRNTRHNDSLRSVRRAHGTTSLGQRSRSPSPKRQESSFSNNPTPTSRYRQGRRLPPTPSKPSTLQLQRPGGVINFPRLTPSPTHF | ||||||
Compositional bias | 1581-1636 | Polar residues | ||||
Sequence: RRAHGTTSLGQRSRSPSPKRQESSFSNNPTPTSRYRQGRRLPPTPSKPSTLQLQRP | ||||||
Region | 1701-1727 | Disordered | ||||
Sequence: LPSPVPNGYKPKTTRLLHSDSDDDDWC |
Sequence similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,727
- Mass (Da)197,369
- Last updated2009-11-03 v1
- Checksum246F7F3713CE8B2B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 12-29 | Polar residues | ||||
Sequence: QGDQGEQTTNTTKRKKTA | ||||||
Compositional bias | 729-749 | Basic and acidic residues | ||||
Sequence: PTKETKKKKEEKVEEEEVEGP | ||||||
Compositional bias | 1528-1573 | Polar residues | ||||
Sequence: IESGSDSRRQSSEGTRSQYLDLPNSDHHWSASSTPAHTPFTRNTRH | ||||||
Compositional bias | 1581-1636 | Polar residues | ||||
Sequence: RRAHGTTSLGQRSRSPSPKRQESSFSNNPTPTSRYRQGRRLPPTPSKPSTLQLQRP |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GQ202021 EMBL· GenBank· DDBJ | ACV86999.1 EMBL· GenBank· DDBJ | mRNA |