C9D7C4 · C9D7C4_TRICA

Function

function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

Features

Showing features for binding site.

117272004006008001,0001,2001,4001,600
TypeIDPosition(s)Description
Binding site289Ca2+ (UniProtKB | ChEBI)
Binding site635Ca2+ (UniProtKB | ChEBI)
Binding site998Ca2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentvoltage-gated calcium channel complex
Molecular Functioncalcium ion binding
Molecular Functionvoltage-gated calcium channel activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Voltage-dependent L-type calcium channel subunit alpha

Gene names

    • Name
      CAC

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Tenebrionidae > Tenebrionidae incertae sedis > Tribolium

Accessions

  • Primary accession
    C9D7C4

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane60-77Helical
Transmembrane98-119Helical
Transmembrane131-151Helical
Transmembrane186-208Helical
Transmembrane275-296Helical
Transmembrane308-330Helical
Transmembrane456-476Helical
Transmembrane488-508Helical
Transmembrane581-603Helical
Transmembrane658-682Helical
Transmembrane777-796Helical
Transmembrane816-837Helical
Transmembrane849-867Helical
Transmembrane913-935Helical
Transmembrane1027-1052Helical
Transmembrane1108-1126Helical
Transmembrane1138-1160Helical
Transmembrane1229-1247Helical
Transmembrane1316-1341Helical

Keywords

  • Cellular component

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region, compositional bias, coiled coil, domain.

TypeIDPosition(s)Description
Region8-31Disordered
Compositional bias12-29Polar residues
Region397-428Disordered
Coiled coil685-720
Region728-749Disordered
Compositional bias729-749Basic and acidic residues
Domain1357-1392EF-hand
Compositional bias1528-1573Polar residues
Region1528-1652Disordered
Compositional bias1581-1636Polar residues
Region1701-1727Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,727
  • Mass (Da)
    197,369
  • Last updated
    2009-11-03 v1
  • Checksum
    246F7F3713CE8B2B
MLAESLRLAAEQGDQGEQTTNTTKRKKTAPGEGASSLFLFSEDNFIRKQTRFIIEWLNPFEYTVILTIIANCVVLALEEHLPNHDKTLLAQNLEATEMYFLAIFCAESLLKILALGFVLHKGSYLRNVWNIMDFFVVLTGVLTVLMQDVNLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGVLHKTCYSLYDIDQIVTEGEDEVPCTTDNETQAKLSGSNWCRDGNSVCLERWEGPNHGITSFDNIGYAMLTVFQCITMEGWTPILYWMNDAMGSTFNWMYFVPLIVLGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKMRRQAQLERELNGYVEWICKAEEVILAEERTTEEEKLHIMKARRRARKKKLKKIGPSKSTDTEDESEMGDDAFGRSARSQGDGKWAKFWRSEKRFRYKIRHTVKTQWFYWSVIVLVFFNTVCVAVEYHGQPQWLTDFLYYAEFVFLGLFLSEMFVKVYALGPRIYFESAFNRFDCVVISGSIFEVVWSEYKDGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGEFNFDDETPPTNFNTFPIALLTVFQILTGEDWNEVMYLGIEALGGHNNGGMIYSLYFIVLMLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQAEENREKQAQELEKEMEALQMDGHTVFSMSPTKETKKKKEEKVEEEEVEGPKPMLPYSSMFILSPTNPVRKFAHGIVNLRYFDFFIMVVICLSSMALASEDPVNEESKWNNALDKLDYAFTVVFASEMFLKIIDLGIILHPGSYLREIWNFMDATVVICALVSMGFNFAQKKAAANLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCLVNSLKNVINILIVYILFHFIFAVIAVQLWNGKFRYCNDASKITEATCQGQYFVYDEDSDVPRAEQRQWTIQSFHYDDVMMAMLTLFAVQTGEGWPQVLQHSMAATYVDQGPIENYRLEMSIFYIVYFVVFPFFFVNIFVALIIITFQEQGEAELQSGEIDKNQKSCIDFTVQAHPLEQFVPETTHGFKYKLWKVVASTPFDYFIMMLIVFNTLLLMMKYDKQGETFTLTLKYLNWLFTGLFTVECILKIVAYGAGNFFKDPWNVFDFITVIGSIIDAGVVELGENFFNVGCLRLFRAARLIKLLRQGDTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKEDPETSITRHNNFRSFTQGLMLLFRCATGESWPNIMLSCVKERPCDPAAKKAPNSCGSNIAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFIRIWAEYDPKATAKIHYTEMYEMLKNMAPPLGFGNKCPNRLAYKKLIRMNMPVDDEGKVNFTTTLFALIRENLSIKMRPPDEMDQADEELRETIKIIWPLQAKTMVDLLVPPNDLLNSGKLTVGKIYGGLLILENWRNTRFGQIQSSTGFLGFGNRSSANQTVINIESGSDSRRQSSEGTRSQYLDLPNSDHHWSASSTPAHTPFTRNTRHNDSLRSVRRAHGTTSLGQRSRSPSPKRQESSFSNNPTPTSRYRQGRRLPPTPSKPSTLQLQRPGGVINFPRLTPSPTHFTLQMPAHAKNYHRDRQFIPATGVAPLTGGSRVPLSFEQGMTLGRGGRILPSPVPNGYKPKTTRLLHSDSDDDDWC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias12-29Polar residues
Compositional bias729-749Basic and acidic residues
Compositional bias1528-1573Polar residues
Compositional bias1581-1636Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ202021
EMBL· GenBank· DDBJ
ACV86999.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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