C8ZLJ7 · C8ZLJ7_CERSP

Function

function

Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 divalent ions per subunit.

Pathway

Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site17ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site19Mg2+ (UniProtKB | ChEBI)
Binding site45K+ (UniProtKB | ChEBI)
Binding site58L-methionine (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site106L-methionine (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site166-168ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site241ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Binding site241L-methionine (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Binding site247-248ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site264ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Binding site268ATP (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Binding site272L-methionine (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionmethionine adenosyltransferase activity
Biological Processone-carbon metabolic process
Biological ProcessS-adenosylmethionine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-adenosylmethionine synthase
  • EC number
  • Short names
    AdoMet synthase
  • Alternative names
    • MAT
    • Methionine adenosyltransferase

Gene names

    • Name
      metK

Organism names

Accessions

  • Primary accession
    C8ZLJ7

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer; dimer of dimers.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain5-108S-adenosylmethionine synthetase N-terminal
Region106-116Flexible loop
Domain117-233S-adenosylmethionine synthetase central
Domain235-377S-adenosylmethionine synthetase C-terminal

Sequence similarities

Belongs to the AdoMet synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    388
  • Mass (Da)
    42,451
  • Last updated
    2009-11-03 v1
  • Checksum
    B07126989F5781DB
MSRMNYVFTSESVSEGHPDKLCDRVSDAVLDAFLAEEPTARVACETFATTGRVVVGGEVGLSDPQKLDEFMERVDGIVRDCVKDIGYEQQEFHWRTIEVQNFLHRQSAHIAQGVDKDGAGDQGIMFGYACRETPELMPAPIQYSHAILRRLAEVRKSGQEPDLRPDAKSQLSLRYENGKPVEVRSIVLSTQHAHEEQTSDDIRAIVEPYIREVLPEGWITEATEWWVNPTGTFVIGGPDGDAGLTGRKIIVDTYGGAAPHGGGAFSGKDPTKVDRSAAYAARYLAKNVVAAGLAERCTLQVSYAIGVAKPLSIYVDTHGTGQVDAAQIEKAVAECMDLTPRGIREHLNLCRPIYARTSAYGHFGRAPEADGGFSWERTDLTDALLKAV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FN552708
EMBL· GenBank· DDBJ
CBF34642.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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