C8ZJM1 · AQY1_YEAS8
- ProteinAquaporin-1
- GeneAQY1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids327 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Water channel required to facilitate the transport of water across membranes. Involved in sporulation, freeze tolerance and osmotolerance. Is non-functional in most laboratory strains.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | plasma membrane | |
Molecular Function | water channel activity |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameAquaporin-1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionC8ZJM1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-48 | Cytoplasmic | ||||
Sequence: MSSNDSNDTDKQHTRLDPTGVDDAYIPPEQPETKHHRFKISKDTLRNH | ||||||
Transmembrane | 49-69 | Helical; Name=1 | ||||
Sequence: FIAAAGEFCGTFMFLWCAYVI | ||||||
Topological domain | 70-91 | Extracellular | ||||
Sequence: CNVANHDVALVAAPDGSHPGQL | ||||||
Transmembrane | 92-112 | Helical; Name=2 | ||||
Sequence: IMIAIGFGFSVMFSIWCFAGV | ||||||
Topological domain | 113-136 | Cytoplasmic | ||||
Sequence: SGGALNPAVSLSLCLARAVSPTRC | ||||||
Transmembrane | 137-157 | Helical; Name=3 | ||||
Sequence: VVMWVSQIVAGMAAGGAASAM | ||||||
Topological domain | 158-176 | Extracellular | ||||
Sequence: TPGEVLFANSLGLGCSRTR | ||||||
Transmembrane | 177-197 | Helical; Name=4 | ||||
Sequence: GLFLEMFGTAILCLTVLMTAV | ||||||
Topological domain | 198-203 | Cytoplasmic | ||||
Sequence: EKRETN | ||||||
Transmembrane | 204-224 | Helical; Name=5 | ||||
Sequence: FMAALPIGISLFIAHVALTAY | ||||||
Topological domain | 225-248 | Extracellular | ||||
Sequence: TGTGVNPARSLGAAVAARYFPHYH | ||||||
Transmembrane | 249-269 | Helical; Name=6 | ||||
Sequence: WIYWIGPLLGSILAWSVWQLL | ||||||
Topological domain | 270-327 | Cytoplasmic | ||||
Sequence: QILDYTTYVTAEKAASTKEKAQKKVKPAVPLLWLKSNFSLLFFISRSLALNVIIFGKN |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000391663 | 1-327 | Aquaporin-1 | |||
Sequence: MSSNDSNDTDKQHTRLDPTGVDDAYIPPEQPETKHHRFKISKDTLRNHFIAAAGEFCGTFMFLWCAYVICNVANHDVALVAAPDGSHPGQLIMIAIGFGFSVMFSIWCFAGVSGGALNPAVSLSLCLARAVSPTRCVVMWVSQIVAGMAAGGAASAMTPGEVLFANSLGLGCSRTRGLFLEMFGTAILCLTVLMTAVEKRETNFMAALPIGISLFIAHVALTAYTGTGVNPARSLGAAVAARYFPHYHWIYWIGPLLGSILAWSVWQLLQILDYTTYVTAEKAASTKEKAQKKVKPAVPLLWLKSNFSLLFFISRSLALNVIIFGKN |
Expression
Developmental stage
Expressed in spores.
Structure
Family & Domains
Features
Showing features for region, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-34 | Disordered | ||||
Sequence: MSSNDSNDTDKQHTRLDPTGVDDAYIPPEQPETK | ||||||
Motif | 118-120 | NPA 1 | ||||
Sequence: NPA | ||||||
Motif | 230-232 | NPA 2 | ||||
Sequence: NPA |
Domain
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence similarities
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length327
- Mass (Da)35,343
- Last updated2009-11-03 v1
- Checksum8358131AF44EE3B5