C8ZDQ3 · GUF1_YEAS8

Function

function

Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

Miscellaneous

This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

Catalytic activity

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site53-60GTP (UniProtKB | ChEBI)
Binding site120-124GTP (UniProtKB | ChEBI)
Binding site174-177GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial matrix
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionmitochondrial ribosome binding
Biological Processpositive regulation of translation
Biological Processtranslation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Translation factor GUF1, mitochondrial
  • EC number
  • Alternative names
    • Elongation factor 4 homolog
      (EF-4
      )
    • GTPase GUF1
    • Ribosomal back-translocase

Gene names

    • Name
      GUF1
    • ORF names
      EC1118_1L7_1464g

Organism names

Accessions

  • Primary accession
    C8ZDQ3

Proteomes

    • Identifier
    • Component
      Chromosome XII, Scaffold EC1118_1L7

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004029011-645Translation factor GUF1, mitochondrial

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain44-228tr-type G

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    645
  • Mass (Da)
    73,249
  • Last updated
    2009-11-03 v1
  • Checksum
    BAEA16E5BEEBAD20
MLKFRIRPVRHIRCYKRHAYFLRYNHTTTPAQKLQAQIEQIPLENYRNFSIVAHVDHGKSTLSDRLLEITHVIDPNARNKQVLDKLEVERERGITIKAQTCSMFYKDKRTGKNYLLHLIDTPGHVDFRGEVSRSYASCGGAILLVDASQGIQAQTVANFYLAFSLGLKLIPVINKIDLNFTDVKQVKDQIVNNFELPEEDIIGVSAKTGLNVEELLLPAIIDRIPPPTGRPDKPFRALLVDSWYDAYLGAVLLVNIVDGFVRKNDKVICAQTKEKYEVKDIGIMYPDRTSTGTLKTGQVGYLVLGMKDSKEAKIGDTIMHLSKVNETEVLPGFEEQKPMVFVGAFPADGIEFKAMDDDMSRLVLNDRSVTLERETSNALGQGWRLGFLGSLHASVFRERLEKEYGSKLIITQPTVPYLVEFTDGKKKLITNPDEFPDGATKRVNVAAFHEPFIEAVMTLPQEYLGSVIRLCDSNRGEQIDITYLNTNGQVMLKYYLPLSHLVDDFFGKLKSVSRGFASLDYEDAGYRISDVVKLQLLVNGNAIDALSRVLHKSEVERVGREWVKKFKEYVKSQLYEVVIQARANNKIIARETIKARRKDVLQKLHASDVSRRKKLLAKQKEGKKHMKTVGNIQINQEAYQAFLRR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FN393080
EMBL· GenBank· DDBJ
CAY81519.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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