C8ZCR2 · NFT1_YEAS8
- ProteinABC transporter NFT1
- GeneNFT1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1558 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | ABC-type transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameABC transporter NFT1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionC8ZCR2
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-29 | Extracellular | ||||
Sequence: MIKNGTCPYWERDDLSECARREYIEFKFP | ||||||
Transmembrane | 30-50 | Helical | ||||
Sequence: LFILLTGMIYAFCKVFRAFYL | ||||||
Topological domain | 51-103 | Cytoplasmic | ||||
Sequence: RGKNHTNEAPEFEEQGNGNHEYARFSVLRLKSAWESRSFCNVNNRSTFDKFKK | ||||||
Transmembrane | 104-124 | Helical | ||||
Sequence: FIEGAFIVLQLTIHLYILSSM | ||||||
Topological domain | 125-130 | Extracellular | ||||
Sequence: LMDNKK | ||||||
Transmembrane | 131-151 | Helical | ||||
Sequence: FFHQGFLVQMFLWILLLVVIT | ||||||
Topological domain | 152-169 | Cytoplasmic | ||||
Sequence: LRLISASQSFRWVLACKR | ||||||
Transmembrane | 170-190 | Helical | ||||
Sequence: DLWAVSFYSYASLFTLSILPL | ||||||
Topological domain | 191-201 | Extracellular | ||||
Sequence: RSVFIGKIKDK | ||||||
Transmembrane | 202-222 | Helical | ||||
Sequence: IMVKYIISETFIDLALLLLLS | ||||||
Topological domain | 223-302 | Cytoplasmic | ||||
Sequence: TSSIEGTRYSFLVENENKKLPPAPTVFGLLTFSRIDRLIWKAYKHCLGNADIWDLDINNKSIAILANFEMSSKKGRLLPN | ||||||
Transmembrane | 303-323 | Helical | ||||
Sequence: IICYFKAVFISQLFLAFVSSF | ||||||
Topological domain | 324-351 | Extracellular | ||||
Sequence: LNFVPSLLMPRILSYVNDPKSKSWNLVS | ||||||
Transmembrane | 352-374 | Helical | ||||
Sequence: LYVSSMLVSKIIATTCRGQGLFL | ||||||
Topological domain | 375-449 | Cytoplasmic | ||||
Sequence: GEKGTMQLRTVLISNIYSKTLRRTILKDSTTSLQKNASTSFEENPDSSEAEPRKKSSRKDNSVNNVMSIDAFKVS | ||||||
Transmembrane | 450-470 | Helical | ||||
Sequence: EAMNTFYLACEAVFMTVTALM | ||||||
Topological domain | 471-481 | Extracellular | ||||
Sequence: ILYSLLGWSAF | ||||||
Transmembrane | 482-504 | Helical | ||||
Sequence: AGTFALLAMIPLNFWCATFYGNY | ||||||
Topological domain | 505-558 | Cytoplasmic | ||||
Sequence: QADQLILTDKRTSGISEALNSIRVIKLLAWENLFYQKIINVRDGEIRLLKKKAT | ||||||
Transmembrane | 559-579 | Helical | ||||
Sequence: IFFLNHLIWFFGPTLVSAITF | ||||||
Topological domain | 580-584 | Extracellular | ||||
Sequence: SVFIK | ||||||
Transmembrane | 585-605 | Helical | ||||
Sequence: FQNQTLTPTIAFTALSLFAIL | ||||||
Topological domain | 606-953 | Cytoplasmic | ||||
Sequence: RTPMDQIASTVSLLIQSFISLERIQDYLNESETRKYEILEQSNTKFGFEDASMEWEAAETSFKLKNISIDFKLNSLNAIIGPTGSGKSSLLLGLLGELNLLSGKIYVPTVESRDDLEIGKDGMTNSMAYCSQTPWLISGTIKDNVVFGEIFNKQKFDDVMKSCCLDKDIKAMTAGIRTDVGDGGFSLSGGQQQRIALARAIYSSSRYLILDDCLSAVDPETALYIYEECLCGPMMKGRTCIITSHNISLVTKRADWLVLLDRGEVKSQGKPSDLIKSNEFLRESINNDSKNTTHNQIDLKRSTTSKKTKNGDPEGGNSQDEVCAEVENFEETKMEGSVKFSAYKWLAD | ||||||
Transmembrane | 954-974 | Helical | ||||
Sequence: YFGGLGVVFVFTSSSILIHGI | ||||||
Topological domain | 975-1013 | Extracellular | ||||
Sequence: TLSQGFWLRYWLDTGSSGSKSTWLYRIVEGHSNIYFLLT | ||||||
Transmembrane | 1014-1034 | Helical | ||||
Sequence: YIIIGLVSSFLTSGKVWIAII | ||||||
Topological domain | 1035-1082 | Cytoplasmic | ||||
Sequence: SGTNVTKKIFAKLLSSILYAKLRFHNVTPTGRIMNRFSKDMDIIDQQL | ||||||
Transmembrane | 1083-1105 | Helical | ||||
Sequence: IPNFEGLSYSVVVCLWIILLIGY | ||||||
Topological domain | 1106-1109 | Extracellular | ||||
Sequence: VTPQ | ||||||
Transmembrane | 1110-1132 | Helical | ||||
Sequence: FLLFAIPLCALYYTVCTLYLRAS | ||||||
Topological domain | 1133-1199 | Cytoplasmic | ||||
Sequence: RELKRIDNINISPIHQLFAEAIKGVTTIRALADERRFITQSLVAIDRSNAPFFYLNMATEWITYRVD | ||||||
Transmembrane | 1200-1220 | Helical | ||||
Sequence: IIGTLVLFSSSVMIIMKASYL | ||||||
Topological domain | 1221-1222 | Extracellular | ||||
Sequence: DA | ||||||
Transmembrane | 1223-1243 | Helical | ||||
Sequence: GLAGILLSNAFSFTETAQWII | ||||||
Topological domain | 1244-1558 | Cytoplasmic | ||||
Sequence: KVFSSVELLMSSVERIKEYTDIPSESNGYISPPANWPQTGDVELKNLSLRYSPHSSKALDNVSFKVKAGTKVGIVGRTGAGKSSIIAAIYRLSDWENGTITIDNKDIKHIPLERLRNSISCIPQDPTLFDGTVRSNLDPFDRYSDVQIYGVLSKVGLIEECDELCLIFEQEQPNFSSHKLRNRFIDLNTVVKSGGSNLSQGQRQLLCLARSMLGARNIMLIDEATASIDYISDAKIQKTIRETMKNTTILTIAHRLRSVIDYDKILVMEMGRVKEYDHPYTLISDRNTIFYRLCRQSGEFENLFELAKVSFDNKR |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000392616 | 1-1558 | ABC transporter NFT1 | |||
Sequence: MIKNGTCPYWERDDLSECARREYIEFKFPLFILLTGMIYAFCKVFRAFYLRGKNHTNEAPEFEEQGNGNHEYARFSVLRLKSAWESRSFCNVNNRSTFDKFKKFIEGAFIVLQLTIHLYILSSMLMDNKKFFHQGFLVQMFLWILLLVVITLRLISASQSFRWVLACKRDLWAVSFYSYASLFTLSILPLRSVFIGKIKDKIMVKYIISETFIDLALLLLLSTSSIEGTRYSFLVENENKKLPPAPTVFGLLTFSRIDRLIWKAYKHCLGNADIWDLDINNKSIAILANFEMSSKKGRLLPNIICYFKAVFISQLFLAFVSSFLNFVPSLLMPRILSYVNDPKSKSWNLVSLYVSSMLVSKIIATTCRGQGLFLGEKGTMQLRTVLISNIYSKTLRRTILKDSTTSLQKNASTSFEENPDSSEAEPRKKSSRKDNSVNNVMSIDAFKVSEAMNTFYLACEAVFMTVTALMILYSLLGWSAFAGTFALLAMIPLNFWCATFYGNYQADQLILTDKRTSGISEALNSIRVIKLLAWENLFYQKIINVRDGEIRLLKKKATIFFLNHLIWFFGPTLVSAITFSVFIKFQNQTLTPTIAFTALSLFAILRTPMDQIASTVSLLIQSFISLERIQDYLNESETRKYEILEQSNTKFGFEDASMEWEAAETSFKLKNISIDFKLNSLNAIIGPTGSGKSSLLLGLLGELNLLSGKIYVPTVESRDDLEIGKDGMTNSMAYCSQTPWLISGTIKDNVVFGEIFNKQKFDDVMKSCCLDKDIKAMTAGIRTDVGDGGFSLSGGQQQRIALARAIYSSSRYLILDDCLSAVDPETALYIYEECLCGPMMKGRTCIITSHNISLVTKRADWLVLLDRGEVKSQGKPSDLIKSNEFLRESINNDSKNTTHNQIDLKRSTTSKKTKNGDPEGGNSQDEVCAEVENFEETKMEGSVKFSAYKWLADYFGGLGVVFVFTSSSILIHGITLSQGFWLRYWLDTGSSGSKSTWLYRIVEGHSNIYFLLTYIIIGLVSSFLTSGKVWIAIISGTNVTKKIFAKLLSSILYAKLRFHNVTPTGRIMNRFSKDMDIIDQQLIPNFEGLSYSVVVCLWIILLIGYVTPQFLLFAIPLCALYYTVCTLYLRASRELKRIDNINISPIHQLFAEAIKGVTTIRALADERRFITQSLVAIDRSNAPFFYLNMATEWITYRVDIIGTLVLFSSSVMIIMKASYLDAGLAGILLSNAFSFTETAQWIIKVFSSVELLMSSVERIKEYTDIPSESNGYISPPANWPQTGDVELKNLSLRYSPHSSKALDNVSFKVKAGTKVGIVGRTGAGKSSIIAAIYRLSDWENGTITIDNKDIKHIPLERLRNSISCIPQDPTLFDGTVRSNLDPFDRYSDVQIYGVLSKVGLIEECDELCLIFEQEQPNFSSHKLRNRFIDLNTVVKSGGSNLSQGQRQLLCLARSMLGARNIMLIDEATASIDYISDAKIQKTIRETMKNTTILTIAHRLRSVIDYDKILVMEMGRVKEYDHPYTLISDRNTIFYRLCRQSGEFENLFELAKVSFDNKR | ||||||
Glycosylation | 4 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 311-621 | ABC transmembrane type-1 1 | ||||
Sequence: FISQLFLAFVSSFLNFVPSLLMPRILSYVNDPKSKSWNLVSLYVSSMLVSKIIATTCRGQGLFLGEKGTMQLRTVLISNIYSKTLRRTILKDSTTSLQKNASTSFEENPDSSEAEPRKKSSRKDNSVNNVMSIDAFKVSEAMNTFYLACEAVFMTVTALMILYSLLGWSAFAGTFALLAMIPLNFWCATFYGNYQADQLILTDKRTSGISEALNSIRVIKLLAWENLFYQKIINVRDGEIRLLKKKATIFFLNHLIWFFGPTLVSAITFSVFIKFQNQTLTPTIAFTALSLFAILRTPMDQIASTVSLLIQ | ||||||
Region | 410-434 | Disordered | ||||
Sequence: NASTSFEENPDSSEAEPRKKSSRKD | ||||||
Compositional bias | 420-434 | Basic and acidic residues | ||||
Sequence: DSSEAEPRKKSSRKD | ||||||
Domain | 651-892 | ABC transporter 1 | ||||
Sequence: FGFEDASMEWEAAETSFKLKNISIDFKLNSLNAIIGPTGSGKSSLLLGLLGELNLLSGKIYVPTVESRDDLEIGKDGMTNSMAYCSQTPWLISGTIKDNVVFGEIFNKQKFDDVMKSCCLDKDIKAMTAGIRTDVGDGGFSLSGGQQQRIALARAIYSSSRYLILDDCLSAVDPETALYIYEECLCGPMMKGRTCIITSHNISLVTKRADWLVLLDRGEVKSQGKPSDLIKSNEFLRESINN | ||||||
Region | 892-926 | Disordered | ||||
Sequence: NDSKNTTHNQIDLKRSTTSKKTKNGDPEGGNSQDE | ||||||
Domain | 961-1251 | ABC transmembrane type-1 2 | ||||
Sequence: VFVFTSSSILIHGITLSQGFWLRYWLDTGSSGSKSTWLYRIVEGHSNIYFLLTYIIIGLVSSFLTSGKVWIAIISGTNVTKKIFAKLLSSILYAKLRFHNVTPTGRIMNRFSKDMDIIDQQLIPNFEGLSYSVVVCLWIILLIGYVTPQFLLFAIPLCALYYTVCTLYLRASRELKRIDNINISPIHQLFAEAIKGVTTIRALADERRFITQSLVAIDRSNAPFFYLNMATEWITYRVDIIGTLVLFSSSVMIIMKASYLDAGLAGILLSNAFSFTETAQWIIKVFSSVEL | ||||||
Domain | 1285-1538 | ABC transporter 2 | ||||
Sequence: VELKNLSLRYSPHSSKALDNVSFKVKAGTKVGIVGRTGAGKSSIIAAIYRLSDWENGTITIDNKDIKHIPLERLRNSISCIPQDPTLFDGTVRSNLDPFDRYSDVQIYGVLSKVGLIEECDELCLIFEQEQPNFSSHKLRNRFIDLNTVVKSGGSNLSQGQRQLLCLARSMLGARNIMLIDEATASIDYISDAKIQKTIRETMKNTTILTIAHRLRSVIDYDKILVMEMGRVKEYDHPYTLISDRNTIFYRLCR |
Sequence similarities
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,558
- Mass (Da)176,347
- Last updated2009-11-03 v1
- Checksum6E0619F4DD96C731
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 420-434 | Basic and acidic residues | ||||
Sequence: DSSEAEPRKKSSRKD |