C8XPB1 · C8XPB1_ZIKV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3417 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1547 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: H | ||||||
Active site | 1571 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: D | ||||||
Active site | 1631 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: S | ||||||
Binding site | 2570 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 2600 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 2601 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 2618 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 2619 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 2645 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 2646 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 2734 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 2953 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 2957 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 2962 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2965 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3228 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 3244 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3363 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus > Orthoflavivirus zikaense
- Virus hosts
Accessions
- Primary accessionC8XPB1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Virion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 250-269 | Helical | ||||
Sequence: WIFRNPGFTLVAVAIAWLLG | ||||||
Transmembrane | 275-295 | Helical | ||||
Sequence: KVIYLVMILLIAPAYSIRCIG | ||||||
Transmembrane | 740-761 | Helical | ||||
Sequence: LFGGMSWFSQILIGTLLVWLGL | ||||||
Transmembrane | 767-792 | Helical | ||||
Sequence: SISLTCLALGGVMIFLSTAVSADVGC | ||||||
Transmembrane | 1172-1191 | Helical | ||||
Sequence: IIMSTSMAVLVAMILGGFSM | ||||||
Transmembrane | 1267-1284 | Helical | ||||
Sequence: VLVNGFALAWLAIRAMAV | ||||||
Transmembrane | 1337-1360 | Helical | ||||
Sequence: FVAALGLTAVRIVDPINVVGLLLL | ||||||
Transmembrane | 1372-1388 | Helical | ||||
Sequence: EVLTAVGLICALAGGFA | ||||||
Transmembrane | 1394-1411 | Helical | ||||
Sequence: MAGPMAAVGLLIVSYVVS | ||||||
Transmembrane | 1467-1490 | Helical | ||||
Sequence: VVLMAICGMNPIAIPFAAGAWYVY | ||||||
Transmembrane | 2168-2187 | Helical | ||||
Sequence: IMLLGLLGTVSLGIFFVLMR | ||||||
Transmembrane | 2194-2210 | Helical | ||||
Sequence: MGFEMVTLGASAWLMWL | ||||||
Transmembrane | 2216-2233 | Helical | ||||
Sequence: ARIACVLIVVFLLLVVLI | ||||||
Transmembrane | 2245-2263 | Helical | ||||
Sequence: NQMAIIIMVAVGLLGLITA | ||||||
Transmembrane | 2300-2321 | Helical | ||||
Sequence: ASAWAIYAALTTLITPAVQHAV | ||||||
Transmembrane | 2328-2347 | Helical | ||||
Sequence: YSLMAMATQAGVLFGMGKGM | ||||||
Transmembrane | 2367-2386 | Helical | ||||
Sequence: LTPLTLIVAIILLVAHYMYL | ||||||
Transmembrane | 2436-2456 | Helical | ||||
Sequence: VLLIAVAVSSAVLLRTAWGWG |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 293↔320 | |||||
Sequence: CIGVSNRDFVEGMSGGTWVDVVLEHGGC | ||||||
Disulfide bond | 350↔406 | |||||
Sequence: CYEASISDMASDSRCPTQGEAYLDKQSDTQYVCKRTLVDRGWGNGCGLFGKGSLVTC | ||||||
Disulfide bond | 364↔395 | |||||
Sequence: CPTQGEAYLDKQSDTQYVCKRTLVDRGWGNGC | ||||||
Disulfide bond | 382↔411 | |||||
Sequence: CKRTLVDRGWGNGCGLFGKGSLVTCAKFTC | ||||||
Disulfide bond | 474↔575 | |||||
Sequence: CEPRTGLDFSDLYYLTMNNKHWLVHKEWFHDIPLPWHAGADTGTPHWNNKEALVEFKDAHAKRQTVVVLGSQEGAVHTALAGALEAEMDGAKGRLFSGHLKC | ||||||
Disulfide bond | 592↔623 | |||||
Sequence: CTAAFTFTKVPAETLHGTVTVEVQYAGTDGPC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1367-1496 | Flavivirus NS2B | ||||
Sequence: SWPPSEVLTAVGLICALAGGFAKADIEMAGPMAAVGLLIVSYVVSGKSVDMYIERAGDITWEKDAEVTGNSPRLDVALDESGDFSLVEEDGPPMREIILKVVLMAICGMNPIAIPFAAGAWYVYVKTGKR | ||||||
Domain | 1497-1674 | Peptidase S7 | ||||
Sequence: SGALWDVPAPKEVKKGETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRLDPYWGDVKQDLVSYCGPWKLDAAWDGVSEVQLLAVPPGERARNIQTLPGIFKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAITQGKREEETPVEC | ||||||
Domain | 1677-1833 | Helicase ATP-binding | ||||
Sequence: PSMLKKKQLTVLDLHPGAGKTRRVLPEIVREAIKKRLRTVILAPTRVVAAEMEEALRGLPVRYMTTAVKVTHSGTEIVDLMCHATFTSRLLQPIRVPNYNLYIMDEAHFTDPSSIAARGYISTRVEMGEAAAIFMTATPPGTRDAFPDSNSPIMDTE | ||||||
Domain | 1828-2007 | Helicase C-terminal | ||||
Sequence: PIMDTEVEVPERAWSSGFDWVTDHSGKTVWFVPSVRNGNEIAACLTKAGKRVIQLSRKTFETEFQKTKNQEWDFVITTDISEMGANFKADRVIDSRRCLKPVILDGERVILAGPMPVTHASAAQRRGRIGRNPNKPGDEYMYGGGCAETDEDHAHWLEARMLLDNIYLQDGLIASLYRPE | ||||||
Domain | 2515-2779 | MRNA cap 0-1 NS5-type MT | ||||
Sequence: GGGTGETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRALKDGVATGGHAVSRGSAKLRWLVERGYLQPYGKVVDLGCGRGGWSYYAATIRKVQEVRGYTKGGPGHEEPMLVQSYGWNIIRLKSGVDVFHMAAESCDTLLCDIGESSSSPEVEETRTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETMERLQRRYGGGLVRVPLSRNSTHEMYWVSGAKSNIIKSVSTTSQLLLGRMDGPRRPVKYEEDVNLGSGTRA | ||||||
Domain | 3043-3193 | RdRp catalytic | ||||
Sequence: GKMYADDTAGWDTRISKFDLENEALITNQMDEGHRTLALAVIKYTYQNKVVKVLRPAEGGKTVMDIISRQDQRGSGQVVTYALNTFTNLVVQLIRNMEAEEVLEMQDLWLLRKPEKVTRWLQSSGWDRLKRMAVSGDDCVVKPIDDRFAHA |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,417
- Mass (Da)378,191
- Last updated2009-11-03 v1
- Checksum3B9B8F66DAA096F9