C8VTV4 · VEA_EMENI

Function

function

Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (PubMed:12223191, PubMed:14665453, PubMed:18556559, PubMed:19210625, PubMed:2076818, PubMed:2253875).
The velvet complex acts as a global regulator for secondary metabolite gene expression (PubMed:18556559).
Controls the expression of the sterigmatocystin and penicillin gene clusters (PubMed:14665453, PubMed:17375284).
Represses the cryptic ors gene cluster producing orsellinic acid and its F9775 derivatives in a laeA-independent manner (PubMed:23841751).
Required for full induction of faoA gene expression by fructosyl amines (PubMed:12375102).
Positively regulates the expression of the early sexual development gene esdC (PubMed:17977758).
Controls the expression of mannoprotein mnpA (PubMed:12620259).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Biological Processsporulation resulting in formation of a cellular spore

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Developmental and secondary metabolism regulator veA
  • Alternative names
    • Velvet complex subunit A

Gene names

    • Name
      veA
    • ORF names
      ANIA_01052

Organism names

Accessions

  • Primary accession
    C8VTV4
  • Secondary accessions
    • O74625

Proteomes

Subcellular Location

Nucleus
Cytoplasm
Note: Enriched in the nucleus in the dark (PubMed:17163983, PubMed:18556559, PubMed:20816830).
Migration to the nucleus depends on the importin alpha carrier protein KapA (PubMed:17163983, PubMed:19318129).
Migration to the nucleus is also controlled by llmF (PubMed:23341778).

Keywords

Phenotypes & Variants

Disruption phenotype

Aboshes light-dependent conidiation, allowing conidiation to occur in the dark (PubMed:2076818).
Impairs formation of sexual structures, even under conditions where sexual development preferentially occurs (PubMed:12223191).
Alters the expression of the transcription factors nsdD, steA and brlA, the penicillin biosynthetic genes ipnA and acvA, as well as of the sterigmatocystin-specific regulatory gene aflR (PubMed:14665453).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis167Leads to strong light induction of conidiation.
Mutagenesis167Leads to loss of sterigmatocystin production in darkness.
Mutagenesis170Leads to an increase of sterigmatocystin production in darkness.
Mutagenesis170Leads to strong light induction of conidiation.
Mutagenesis183Leads to strong light induction of conidiation.
Mutagenesis183Leads to increased production of sterigmatocystin in darkness and after illumination.
Mutagenesis254Leads to increased production of sterigmatocystin in darkness and after illumination.

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004357591-573Developmental and secondary metabolism regulator veA
Modified residue167Phosphothreonine
Modified residue170Phosphothreonine
Modified residue183Phosphoserine
Modified residue254Phosphotyrosine

Post-translational modification

Phosphorylated at Thr-167, Thr-170, Ser-183 and Tyr-254 (PubMed:26564476).
Thr-167 should be phosphorylated and T170 and S183 should be dephosphorylated to achieve light induction of conidiation (PubMed:26564476).
Phosphorylation of Ser-183 and Tyr-254 influence sterigmatocystin production in a light-independent manner (PubMed:26564476).
Phosphorylation of Thr-167 and Thr-170 modulates expression of veA (PubMed:26564476).

Keywords

PTM databases

Expression

Induction

Expressed almost constitutively at an increased level throughout the asexual and sexual developmental processes (PubMed:12223191).
Negatively regulates its own expression (PubMed:19479257).
Expression is derepressed in light-illuminated conditions (PubMed:19479257).
Expression is regulated by laeA (PubMed:21152013).
Regulates its own expression, depending on its phosphorylation state (PubMed:26564476).

Interaction

Subunit

Component of the heterotrimeric velvet complex composed of laeA, veA and velB; VeA acting as a bridging protein between laeA and velB (PubMed:18556559).
Interacts with the light-sensing phytochrome fphA (PubMed:18291652, PubMed:18936976).
Interacts with llmF (PubMed:23341778).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain, motif, compositional bias.

TypeIDPosition(s)Description
Region1-24Disordered
Domain27-230Velvet
Region39-63Disordered
Motif41-46Nuclear localization signal
Region236-295Disordered
Compositional bias237-256Basic and acidic residues
Compositional bias272-289Polar residues
Region307-367Disordered
Compositional bias316-360Pro residues
Compositional bias384-492Polar residues
Region384-573Disordered
Region459-498PEST
Compositional bias512-526Basic and acidic residues

Domain

The C-terminal PEST domain is a region rich in proline, glutamic acid, serine and threonine residues that is required for the light-dependent regulation of development and secondary metabolism.

Sequence similarities

Belongs to the velvet family. VeA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    573
  • Mass (Da)
    63,113
  • Last updated
    2016-03-16 v2
  • Checksum
    584C7639C5E8FC1D
MATLAAPPPPLGESGNSNSVSRITREGKKITYKLNIMQQPKRARACGQGSKSHTDRRPVDPPPVIELNIFESDPHDDSNKTDITFVYNANFFLFATLEPERPIATGKLMTNQGSPVLTGVPVAGVAYLDKPNRAGYFIFPDLSVRNEGSYRFSFHLFEQIKDPKDATEGTQPMPSPVPGKLSSPQEFLEFRLEVISNPFIVYSAKKFPGLTTSTPISRMIAEQGCRVRIRRDVRMRRRGDKRTEDYDYDNERGYNNRRPDQYAGSDAYANAPERPRSTSISTNMDPYSYPSRRPSAVEYGQPIAQPYQRPMASTPAPSSTPIPAPIPMPGPVALPPSTPSPASAHAPAPPSVPLAAPPPLHTPSYQSHLSFGATQTQYPAPQLSHIPQQTTTPTHPYSPRSSISHSRNQSISEYEPSMGYPGSQTRLSAERPSYGQPSQTTSLPPLRHSLEPSVNSRSKTPSNMITSLPPIQSLSELPSTTSQPSSAIGSSPANEPGPRLWETNSMLSKRTYEESFGHDDRPLYNGMRPDSESYPGGMQRRPSYERSSLLDGPDQMAYKRANGRMVSKPATMR

Sequence caution

The sequence CBF88249.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias237-256Basic and acidic residues
Compositional bias272-289Polar residues
Compositional bias316-360Pro residues
Compositional bias384-492Polar residues
Compositional bias512-526Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U95045
EMBL· GenBank· DDBJ
AAC26841.1
EMBL· GenBank· DDBJ
Genomic DNA
AF109316
EMBL· GenBank· DDBJ
AAD42946.1
EMBL· GenBank· DDBJ
mRNA
AF335465
EMBL· GenBank· DDBJ
AAK21245.1
EMBL· GenBank· DDBJ
Genomic DNA
BN001308
EMBL· GenBank· DDBJ
CBF88249.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

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