C8VTV4 · VEA_EMENI
- ProteinDevelopmental and secondary metabolism regulator veA
- GeneveA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids573 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (PubMed:12223191, PubMed:14665453, PubMed:18556559, PubMed:19210625, PubMed:2076818, PubMed:2253875).
The velvet complex acts as a global regulator for secondary metabolite gene expression (PubMed:18556559).
Controls the expression of the sterigmatocystin and penicillin gene clusters (PubMed:14665453, PubMed:17375284).
Represses the cryptic ors gene cluster producing orsellinic acid and its F9775 derivatives in a laeA-independent manner (PubMed:23841751).
Required for full induction of faoA gene expression by fructosyl amines (PubMed:12375102).
Positively regulates the expression of the early sexual development gene esdC (PubMed:17977758).
Controls the expression of mannoprotein mnpA (PubMed:12620259).
The velvet complex acts as a global regulator for secondary metabolite gene expression (PubMed:18556559).
Controls the expression of the sterigmatocystin and penicillin gene clusters (PubMed:14665453, PubMed:17375284).
Represses the cryptic ors gene cluster producing orsellinic acid and its F9775 derivatives in a laeA-independent manner (PubMed:23841751).
Required for full induction of faoA gene expression by fructosyl amines (PubMed:12375102).
Positively regulates the expression of the early sexual development gene esdC (PubMed:17977758).
Controls the expression of mannoprotein mnpA (PubMed:12620259).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Biological Process | sporulation resulting in formation of a cellular spore |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameDevelopmental and secondary metabolism regulator veA
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Nidulantes
Accessions
- Primary accessionC8VTV4
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Aboshes light-dependent conidiation, allowing conidiation to occur in the dark (PubMed:2076818).
Impairs formation of sexual structures, even under conditions where sexual development preferentially occurs (PubMed:12223191).
Alters the expression of the transcription factors nsdD, steA and brlA, the penicillin biosynthetic genes ipnA and acvA, as well as of the sterigmatocystin-specific regulatory gene aflR (PubMed:14665453).
Impairs formation of sexual structures, even under conditions where sexual development preferentially occurs (PubMed:12223191).
Alters the expression of the transcription factors nsdD, steA and brlA, the penicillin biosynthetic genes ipnA and acvA, as well as of the sterigmatocystin-specific regulatory gene aflR (PubMed:14665453).
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 167 | Leads to strong light induction of conidiation. | ||||
Sequence: T → E | ||||||
Mutagenesis | 167 | Leads to loss of sterigmatocystin production in darkness. | ||||
Sequence: T → V | ||||||
Mutagenesis | 170 | Leads to an increase of sterigmatocystin production in darkness. | ||||
Sequence: T → E | ||||||
Mutagenesis | 170 | Leads to strong light induction of conidiation. | ||||
Sequence: T → V | ||||||
Mutagenesis | 183 | Leads to strong light induction of conidiation. | ||||
Sequence: S → A | ||||||
Mutagenesis | 183 | Leads to increased production of sterigmatocystin in darkness and after illumination. | ||||
Sequence: S → E | ||||||
Mutagenesis | 254 | Leads to increased production of sterigmatocystin in darkness and after illumination. | ||||
Sequence: Y → E or F |
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000435759 | 1-573 | Developmental and secondary metabolism regulator veA | |||
Sequence: MATLAAPPPPLGESGNSNSVSRITREGKKITYKLNIMQQPKRARACGQGSKSHTDRRPVDPPPVIELNIFESDPHDDSNKTDITFVYNANFFLFATLEPERPIATGKLMTNQGSPVLTGVPVAGVAYLDKPNRAGYFIFPDLSVRNEGSYRFSFHLFEQIKDPKDATEGTQPMPSPVPGKLSSPQEFLEFRLEVISNPFIVYSAKKFPGLTTSTPISRMIAEQGCRVRIRRDVRMRRRGDKRTEDYDYDNERGYNNRRPDQYAGSDAYANAPERPRSTSISTNMDPYSYPSRRPSAVEYGQPIAQPYQRPMASTPAPSSTPIPAPIPMPGPVALPPSTPSPASAHAPAPPSVPLAAPPPLHTPSYQSHLSFGATQTQYPAPQLSHIPQQTTTPTHPYSPRSSISHSRNQSISEYEPSMGYPGSQTRLSAERPSYGQPSQTTSLPPLRHSLEPSVNSRSKTPSNMITSLPPIQSLSELPSTTSQPSSAIGSSPANEPGPRLWETNSMLSKRTYEESFGHDDRPLYNGMRPDSESYPGGMQRRPSYERSSLLDGPDQMAYKRANGRMVSKPATMR | ||||||
Modified residue | 167 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 170 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 183 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 254 | Phosphotyrosine | ||||
Sequence: Y |
Post-translational modification
Phosphorylated at Thr-167, Thr-170, Ser-183 and Tyr-254 (PubMed:26564476).
Thr-167 should be phosphorylated and T170 and S183 should be dephosphorylated to achieve light induction of conidiation (PubMed:26564476).
Phosphorylation of Ser-183 and Tyr-254 influence sterigmatocystin production in a light-independent manner (PubMed:26564476).
Phosphorylation of Thr-167 and Thr-170 modulates expression of veA (PubMed:26564476).
Thr-167 should be phosphorylated and T170 and S183 should be dephosphorylated to achieve light induction of conidiation (PubMed:26564476).
Phosphorylation of Ser-183 and Tyr-254 influence sterigmatocystin production in a light-independent manner (PubMed:26564476).
Phosphorylation of Thr-167 and Thr-170 modulates expression of veA (PubMed:26564476).
Keywords
- PTM
PTM databases
Expression
Induction
Expressed almost constitutively at an increased level throughout the asexual and sexual developmental processes (PubMed:12223191).
Negatively regulates its own expression (PubMed:19479257).
Expression is derepressed in light-illuminated conditions (PubMed:19479257).
Expression is regulated by laeA (PubMed:21152013).
Regulates its own expression, depending on its phosphorylation state (PubMed:26564476).
Negatively regulates its own expression (PubMed:19479257).
Expression is derepressed in light-illuminated conditions (PubMed:19479257).
Expression is regulated by laeA (PubMed:21152013).
Regulates its own expression, depending on its phosphorylation state (PubMed:26564476).
Interaction
Subunit
Component of the heterotrimeric velvet complex composed of laeA, veA and velB; VeA acting as a bridging protein between laeA and velB (PubMed:18556559).
Interacts with the light-sensing phytochrome fphA (PubMed:18291652, PubMed:18936976).
Interacts with llmF (PubMed:23341778).
Interacts with the light-sensing phytochrome fphA (PubMed:18291652, PubMed:18936976).
Interacts with llmF (PubMed:23341778).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, motif, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-24 | Disordered | ||||
Sequence: MATLAAPPPPLGESGNSNSVSRIT | ||||||
Domain | 27-230 | Velvet | ||||
Sequence: GKKITYKLNIMQQPKRARACGQGSKSHTDRRPVDPPPVIELNIFESDPHDDSNKTDITFVYNANFFLFATLEPERPIATGKLMTNQGSPVLTGVPVAGVAYLDKPNRAGYFIFPDLSVRNEGSYRFSFHLFEQIKDPKDATEGTQPMPSPVPGKLSSPQEFLEFRLEVISNPFIVYSAKKFPGLTTSTPISRMIAEQGCRVRIR | ||||||
Region | 39-63 | Disordered | ||||
Sequence: QPKRARACGQGSKSHTDRRPVDPPP | ||||||
Motif | 41-46 | Nuclear localization signal | ||||
Sequence: KRARAC | ||||||
Region | 236-295 | Disordered | ||||
Sequence: RRRGDKRTEDYDYDNERGYNNRRPDQYAGSDAYANAPERPRSTSISTNMDPYSYPSRRPS | ||||||
Compositional bias | 237-256 | Basic and acidic residues | ||||
Sequence: RRGDKRTEDYDYDNERGYNN | ||||||
Compositional bias | 272-289 | Polar residues | ||||
Sequence: PERPRSTSISTNMDPYSY | ||||||
Region | 307-367 | Disordered | ||||
Sequence: YQRPMASTPAPSSTPIPAPIPMPGPVALPPSTPSPASAHAPAPPSVPLAAPPPLHTPSYQS | ||||||
Compositional bias | 316-360 | Pro residues | ||||
Sequence: APSSTPIPAPIPMPGPVALPPSTPSPASAHAPAPPSVPLAAPPPL | ||||||
Compositional bias | 384-492 | Polar residues | ||||
Sequence: SHIPQQTTTPTHPYSPRSSISHSRNQSISEYEPSMGYPGSQTRLSAERPSYGQPSQTTSLPPLRHSLEPSVNSRSKTPSNMITSLPPIQSLSELPSTTSQPSSAIGSSP | ||||||
Region | 384-573 | Disordered | ||||
Sequence: SHIPQQTTTPTHPYSPRSSISHSRNQSISEYEPSMGYPGSQTRLSAERPSYGQPSQTTSLPPLRHSLEPSVNSRSKTPSNMITSLPPIQSLSELPSTTSQPSSAIGSSPANEPGPRLWETNSMLSKRTYEESFGHDDRPLYNGMRPDSESYPGGMQRRPSYERSSLLDGPDQMAYKRANGRMVSKPATMR | ||||||
Region | 459-498 | PEST | ||||
Sequence: KTPSNMITSLPPIQSLSELPSTTSQPSSAIGSSPANEPGP | ||||||
Compositional bias | 512-526 | Basic and acidic residues | ||||
Sequence: YEESFGHDDRPLYNG |
Domain
The C-terminal PEST domain is a region rich in proline, glutamic acid, serine and threonine residues that is required for the light-dependent regulation of development and secondary metabolism.
Sequence similarities
Belongs to the velvet family. VeA subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length573
- Mass (Da)63,113
- Last updated2016-03-16 v2
- Checksum584C7639C5E8FC1D
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 237-256 | Basic and acidic residues | ||||
Sequence: RRGDKRTEDYDYDNERGYNN | ||||||
Compositional bias | 272-289 | Polar residues | ||||
Sequence: PERPRSTSISTNMDPYSY | ||||||
Compositional bias | 316-360 | Pro residues | ||||
Sequence: APSSTPIPAPIPMPGPVALPPSTPSPASAHAPAPPSVPLAAPPPL | ||||||
Compositional bias | 384-492 | Polar residues | ||||
Sequence: SHIPQQTTTPTHPYSPRSSISHSRNQSISEYEPSMGYPGSQTRLSAERPSYGQPSQTTSLPPLRHSLEPSVNSRSKTPSNMITSLPPIQSLSELPSTTSQPSSAIGSSP | ||||||
Compositional bias | 512-526 | Basic and acidic residues | ||||
Sequence: YEESFGHDDRPLYNG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U95045 EMBL· GenBank· DDBJ | AAC26841.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF109316 EMBL· GenBank· DDBJ | AAD42946.1 EMBL· GenBank· DDBJ | mRNA | ||
AF335465 EMBL· GenBank· DDBJ | AAK21245.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BN001308 EMBL· GenBank· DDBJ | CBF88249.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. |