C8VQY7 · YPT7_EMENI

Function

function

Ypt/Rab-type GTPases are key regulators of membrane trafficking and intracellular vesicular transport. They act as molecular switches that convert between GTP-bound and GDP-bound states, and regulate virtually all steps of membrane traffic from the formation of the transport vesicle at the donor membrane to its fusion at the target membrane. In the GDP-bound state, Ypt proteins are predominantly cytosolic, solubilized through the interaction with a GDP dissociation inhibitor (GDI). In the GTP-bound state, the proteins are membrane bound and interact with specific effector proteins that select cargo, promote vesicle movement, or verify the correct site of fusion (By similarity).
AvaA functions in vacuolar biogenesis (PubMed:12095681).

Activity regulation

Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP).

Features

Showing features for binding site.

120520406080100120140160180200
TypeIDPosition(s)Description
Binding site17-23GTP (UniProtKB | ChEBI)
Binding site33-40GTP (UniProtKB | ChEBI)
Binding site66GTP (UniProtKB | ChEBI)
Binding site125-128GTP (UniProtKB | ChEBI)
Binding site157-159GTP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentfungal-type vacuole membrane
Cellular Componentlate endosome
Cellular Componentvacuolar membrane
Cellular Componentvacuole
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological Processendosome organization
Biological Processregulation of vacuole fusion, non-autophagic
Biological Processvacuole fusion, non-autophagic

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Ypt/Rab-type GTPase avaA
  • Alternative names
    • Aspergillus vacuolar morphology protein A
    • YPT7 homolog avaA

Gene names

    • Name
      avaA
    • ORF names
      AN0089, ANIA_00089

Organism names

Accessions

  • Primary accession
    C8VQY7
  • Secondary accessions
    • Q5BH91
    • Q8TGD9

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

Displays highly fragmented vacuoles.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis22Constitutively in the GDP-bound conformation. Causes loss of function during vacuolar morphogenesis.
Mutagenesis67Constitutively in the GTP-bound conformation. Promotes vacuolar fusion resulting in large swollen vacuoles.

PTM/Processing

Features

Showing features for chain, lipidation, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004510561-205Ypt/Rab-type GTPase avaA
Lipidation203S-geranylgeranyl cysteine
Modified residue205Cysteine methyl ester
Lipidation205S-geranylgeranyl cysteine

Keywords

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif37-45Effector region

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    205
  • Mass (Da)
    22,941
  • Last updated
    2009-11-03 v1
  • Checksum
    0E927E2D76F6BB32
MSSRKKVMLKVIILGDSGVGKTSLMNQYVNKKFSGSYKATIGADFLTKEVLVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVYDVNNSKSFEALDSWRDEFLIQASPRDPESFPFVVIGNKIDMEESKRMISSKRAMTFCQSKGNIPYFETSAKEAVNVEQAFEVIARSALAQEEAEEYGGDYTDPINIHDTTERDGCAC

Sequence caution

The sequence EAA65267.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB072431
EMBL· GenBank· DDBJ
BAB88682.1
EMBL· GenBank· DDBJ
Genomic DNA
BN001308
EMBL· GenBank· DDBJ
CBF90222.1
EMBL· GenBank· DDBJ
Genomic DNA
AACD01000003
EMBL· GenBank· DDBJ
EAA65267.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

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