C8VPJ1 · GUF1_EMENI

Function

function

Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

Catalytic activity

Features

Showing features for binding site.

166250100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site73-80GTP (UniProtKB | ChEBI)
Binding site137-141GTP (UniProtKB | ChEBI)
Binding site191-194GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrion
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionmitochondrial ribosome binding
Biological Processpositive regulation of translation
Biological Processtranslation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Translation factor guf1, mitochondrial
  • EC number
  • Alternative names
    • Elongation factor 4 homolog
      (EF-4
      )
    • GTPase guf1
    • Ribosomal back-translocase

Gene names

    • Name
      guf1
    • ORF names
      AN10315

Organism names

Accessions

  • Primary accession
    C8VPJ1
  • Secondary accessions
    • Q5BAB8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for transit peptide, chain.

Type
IDPosition(s)Description
Transit peptide1-42Mitochondrion
ChainPRO_000040288543-662Translation factor guf1, mitochondrial

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain64-244tr-type G

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    662
  • Mass (Da)
    73,827
  • Last updated
    2009-11-03 v1
  • Checksum
    ECF6AB24C8D84EED
MRGCLQLARWLSAAPNWPASSLLKAPGSSFATRLFTTTSSYKAKGPSKVPMTDLEARISAIPIERYRNFCIVAHVDHGKSTLSDRLLELTGTIKPGMNKQVLDKLDVERERGITVKAQTCTMIYNHKGEDYLLHLVDTPGHVDFRAEVSRSYASCGGALLLVDASQGIQAQTVANFYLAFSQGLELIPVINKVDLPSAEPERALEQLEQSFELDTEDAVLVSAKTGLNVEQLLPTVVEKIPAPIGDCKRPLRMLLVDSWYDSYKGVICLVRVFDGEVRAGQQVVSFATGIKYYVGEVGIQYPLETPQTVLRAGQVGYIFFNPGMKRSKEAKIGDTFTTVGSEKAVQPLPGFEEPKAMVFVAAYPVDADHFEHLEDSINQLVLNDRSITVQKESSEALGAGFRLGFLGTLHCSVFEDRLRQEHGASIIITPPSVPVKVVWKDGKEDIITNPNRFPDEDDVRMKVAELQEPYVMATLTFPDEYLGTVIELCEANRGEQKSLEYFTPTQVILKYELPLAQLVDDFFGKLKGGTKGYASLDYEESGWKPSNIVKLQLLVNKAPVDAVARLVHYSQTDRLGRQWVTKFKEHVDRQLFEIIIQAAVGKKIVARETVKPYRKDVLAKLHASDVSRRRKLLEKQKEGRKRLRAVGNVVIEHKAFQAFLAK

Sequence caution

The sequence EAA63997.1 differs from that shown. Reason: Erroneous gene model prediction The predicted gene AN2512 has been split into 2 genes: AN10315 and AN10316.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AACD01000042
EMBL· GenBank· DDBJ
EAA63997.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
BN001307
EMBL· GenBank· DDBJ
CBF87002.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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