C8VK15 · HXNZ_EMENI
- ProteinMajor facilitator-type transporter hxnZ
- GenehxnZ
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids553 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Major facilitator-type transporter, part of the hnx cluster involved in the purine degradation (PubMed:29212709).
The nicotinate hydroxylase hnxS accepts nicotinate as a substrate and catalyzes the first step of nicotinate catabolism (PubMed:29212709).
The major facilitator-type transporters hxnP and hxnZ are probably involved in the uptake of nicotinate-derived metabolites, and the oxidoreductases hxnT and hxnY in the further metabolism of 6-OH nicotinic acid (PubMed:29212709).
The nicotinate hydroxylase hnxS accepts nicotinate as a substrate and catalyzes the first step of nicotinate catabolism (PubMed:29212709).
The major facilitator-type transporters hxnP and hxnZ are probably involved in the uptake of nicotinate-derived metabolites, and the oxidoreductases hxnT and hxnY in the further metabolism of 6-OH nicotinic acid (PubMed:29212709).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | transmembrane transporter activity |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMajor facilitator-type transporter hxnZ
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Nidulantes
Accessions
- Primary accessionC8VK15
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 89-109 | Helical | ||||
Sequence: FTVAGFGWIVDNFCSQGISAV | ||||||
Transmembrane | 128-148 | Helical | ||||
Sequence: VAYYVGMIIGASFWGISSDLI | ||||||
Transmembrane | 152-172 | Helical | ||||
Sequence: PAFNSTLAIAGIFLCAAAGTS | ||||||
Transmembrane | 174-194 | Helical | ||||
Sequence: FIAFSALWAVIGTAAGGNVVC | ||||||
Transmembrane | 213-233 | Helical | ||||
Sequence: ALSGWWNLGQLVVSLLAWVFL | ||||||
Transmembrane | 257-277 | Helical | ||||
Sequence: YTLITLGGLSLAFTFVRIFVF | ||||||
Transmembrane | 366-386 | Helical | ||||
Sequence: ALIWAVWLIIGIAYPLYFNFL | ||||||
Transmembrane | 409-429 | Helical | ||||
Sequence: IQSAVGVVGPLSAAVLVNTFL | ||||||
Transmembrane | 433-453 | Helical | ||||
Sequence: WMMGISSIVTGVFLFAYVGVK | ||||||
Transmembrane | 459-481 | Helical | ||||
Sequence: LAFSCVTGLLANFANQLSEYAIM | ||||||
Transmembrane | 496-516 | Helical | ||||
Sequence: TASGTAASLLRFGGLVASLIA | ||||||
Transmembrane | 525-545 | Helical | ||||
Sequence: PIYASAALWVGVGVLCFGLPF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000443343 | 1-553 | Major facilitator-type transporter hxnZ | |||
Sequence: MDISYPVINAGGLKNIASQIIMEIELDKRENRPTDNVPPDDIGKIEVVDDAEMEQFYGSSTTDAYRLKSELVSQCMADIGMGRFQWKLFTVAGFGWIVDNFCSQGISAVQPPIQQEFSGIKQVSYSSVAYYVGMIIGASFWGISSDLIGRKPAFNSTLAIAGIFLCAAAGTSNFIAFSALWAVIGTAAGGNVVCDSMILLEFIPGSHQYLLTALSGWWNLGQLVVSLLAWVFLANFSCPTDATPDTCSRADNMGWRYTLITLGGLSLAFTFVRIFVFKMPETPRYLLSQGNDQAAVDAVNYVARQNGKPEPLTLSMLQAIDVRLGFTPNAEERLSTKDILKENMQEFRGEHYQALFATRKLSQHTALIWAVWLIIGIAYPLYFNFLPSYLATRFTQDSSLDLTYRNYCIQSAVGVVGPLSAAVLVNTFLGRRWMMGISSIVTGVFLFAYVGVKTPMSSLAFSCVTGLLANFANQLSEYAIMYAFTPESFPAPHRGTASGTAASLLRFGGLVASLIASETGFTTAPIYASAALWVGVGVLCFGLPFETHGHAAI | ||||||
Glycosylation | 235 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Expression
Induction
Expression is induced by nicotinate and 6-OH nicotinate, subject to nitrogen metabolite repression mediated by the GATA factor areA, and strictly regulated by the cluster-specific transcription regulator hnxR (PubMed:29212709).
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length553
- Mass (Da)60,145
- Last updated2009-11-03 v1
- Checksum3497F3E1030F8972
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BN001306 EMBL· GenBank· DDBJ | CBF82387.1 EMBL· GenBank· DDBJ | Genomic DNA |