C8V606 · C8V606_EMENI

Function

function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenteuchromatin
Cellular ComponentHDA1 complex
Cellular Componentheterochromatin island
Cellular Componenthistone deacetylase complex
Cellular Componentmating-type region heterochromatin
Cellular Componentnucleolus
Cellular Componentpericentric heterochromatin
Cellular ComponentrDNA heterochromatin
Cellular ComponentSHREC complex
Cellular Componentsubtelomeric heterochromatin
Molecular Functionchromatin binding
Molecular Functionhistone deacetylase activity
Molecular Functionhistone H3K14 deacetylase activity
Molecular Functionidentical protein binding
Biological Processcellular response to oxidative stress
Biological Processepigenetic regulation of gene expression
Biological Processnegative regulation of penicillin biosynthetic process
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processnegative regulation of transcription by transcription factor localization
Biological Processpenicillin metabolic process
Biological Processpericentric heterochromatin formation
Biological Processpositive regulation of transcription by RNA polymerase II
Biological ProcessrDNA heterochromatin formation
Biological Processregulation of secondary metabolite biosynthetic process
Biological Processregulation of sterigmatocystin biosynthetic process
Biological Processsilent mating-type cassette heterochromatin formation
Biological ProcesssiRNA-independent facultative heterochromatin formation
Biological Processsterigmatocystin metabolic process
Biological Processsubtelomeric heterochromatin formation

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone deacetylase
  • EC number

Gene names

    • ORF names
      ANIA_08042

Organism names

Accessions

  • Primary accession
    C8V606

Proteomes

Organism-specific databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain146-456Histone deacetylase
Domain505-742Arb2-like
Compositional bias743-758Basic and acidic residues
Region743-766Disordered

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    766
  • Mass (Da)
    85,236
  • Last updated
    2009-11-03 v1
  • Checksum
    D826B9AF3E5B5159
MVDDEDIIMGEAGYHSANPNTAIAAGQQTTHGHLNGRSDPYLAPPLLSQPMQMPVVQAGNSQTQESSATTDEARVLSPKIDLNSTVPADAADITPDYQDSLVDEYSDYAEESKEAPGLPLASLPSGLCYDVQMRYHCEVRPTSDVHPEDPRRIYYIYKELCRAGLVDDIESTRPLVARPLKRIHARNATEEEISLVHTAAHYAFVESTKDMSDEELIALEHTRDSIYFNNLTFASSLLSVGGAIETCLAVATRKVKNAIAVIRPPGHHAEHDKTMGFCLFNNVSVAARVCQQRLGLSCRKIMILDWDVHHGNGIQKAFYDDPNVLYISLHVYQNGSFYPGEKDGDADFCGAGAGEGKNVNIPWPSQGMGDGDYIYAFHQVVMPIAQEFDPDLVIIASGFDAAAGDTLGGCFVTPACYAHMTHMLMTLAQGKVAVCLEGGYNFRSISKSALAVTKTLMGNPPDRLSFTCPSEAAISTIRRVSSIQSDYWKCMYPKAIKNEGVWTDRLHDIIRAYQAKQLYDNYKLTSLYIYRTAISKSFENQVLARPEIMGLPHPLTNNLEAHNCWLADVMKDYVQWAVGKGYAVIDVNIPKHVTTEPSSGRFEEEDENRPTATEELAGYLWDNYIDPNEATEIFLVGIGNAFYGVANLLINRETLYQRVNGVISFVAKDPVRAVASHTQVWLSRWYRDNSLVFVSKAHGVWKSDRKATKRYGKLIQSSREGLSDMLMHHKDEVFQWIEDRIEPESEETEEEKPVKRSPTKAAPKAA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias743-758Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BN001302
EMBL· GenBank· DDBJ
CBF73762.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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