C7ZMZ8 · C7ZMZ8_FUSV7

Function

function

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site114ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchromosome, telomeric region
Molecular FunctionATP binding
Molecular Functionhistone H2AS1 kinase activity
Biological Processpeptidyl-serine phosphorylation
Biological Processregulation of mRNA processing
Biological Processspliceosomal complex assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    EKC/KEOPS complex subunit BUD32
  • EC number
  • Alternative names
    • Atypical Serine/threonine protein kinase BUD32
    • EKC/KEOPS complex subunit bud32

Gene names

    • ORF names
      NECHADRAFT_82323

Organism names

Accessions

  • Primary accession
    C7ZMZ8

Proteomes

Organism-specific databases

Subcellular Location

Interaction

Subunit

Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-21Polar residues
Region1-26Disordered
Domain85-431Protein kinase

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    453
  • Mass (Da)
    51,185
  • Last updated
    2009-10-13 v1
  • Checksum
    0CA08D5195380684
MSTVTSDPRSPRSSTPESILSDTDRGETKNCRHYITINWDDHPPATAEDVYLGGPEDDVESLEGYHEGGFHPVKIGDCFGESAQYRVLHKLGYGGYATVWLCRDTHHSRYVALKILMATVNPDTIPELEILSQLDRSLPGAEFIAIPLEHFTFQGPNGTHQALVLPVLGPRVSPDIWRHMKTNPNITLRRLARQVTKALDFLHKNQICHGDFRPGNILMNLANIDHLPETELITLIGPPITFRVRHESGGEIPSSCPPCLIERCNLGRLSDYFVDNITLIDFGESFYFSSPPKALKSPIPGPSTDLWALGCTLFEIRQQIKLFYMLPNTDEIIAEIVMLFGKLPDSLWDKWDSRKKFFDDSGHGLRFQSATLEMFLTRELELWEPEPGATWSSLFTPEAEQKQLADLIYKLLKYNGTERLTAEEALKHEWLKGAEECTQLHHQGSRHASGTIQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-21Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GG698960
EMBL· GenBank· DDBJ
EEU34621.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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