C7ZMZ8 · C7ZMZ8_FUSV7
- ProteinEKC/KEOPS complex subunit BUD32
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids453 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome, telomeric region | |
Molecular Function | ATP binding | |
Molecular Function | histone H2AS1 kinase activity | |
Biological Process | peptidyl-serine phosphorylation | |
Biological Process | regulation of mRNA processing | |
Biological Process | spliceosomal complex assembly |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEKC/KEOPS complex subunit BUD32
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium > Fusarium solani species complex > Fusarium vanettenii
Accessions
- Primary accessionC7ZMZ8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-21 | Polar residues | ||||
Sequence: MSTVTSDPRSPRSSTPESILS | ||||||
Region | 1-26 | Disordered | ||||
Sequence: MSTVTSDPRSPRSSTPESILSDTDRG | ||||||
Domain | 85-431 | Protein kinase | ||||
Sequence: YRVLHKLGYGGYATVWLCRDTHHSRYVALKILMATVNPDTIPELEILSQLDRSLPGAEFIAIPLEHFTFQGPNGTHQALVLPVLGPRVSPDIWRHMKTNPNITLRRLARQVTKALDFLHKNQICHGDFRPGNILMNLANIDHLPETELITLIGPPITFRVRHESGGEIPSSCPPCLIERCNLGRLSDYFVDNITLIDFGESFYFSSPPKALKSPIPGPSTDLWALGCTLFEIRQQIKLFYMLPNTDEIIAEIVMLFGKLPDSLWDKWDSRKKFFDDSGHGLRFQSATLEMFLTRELELWEPEPGATWSSLFTPEAEQKQLADLIYKLLKYNGTERLTAEEALKHEWL |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length453
- Mass (Da)51,185
- Last updated2009-10-13 v1
- Checksum0CA08D5195380684
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-21 | Polar residues | ||||
Sequence: MSTVTSDPRSPRSSTPESILS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GG698960 EMBL· GenBank· DDBJ | EEU34621.1 EMBL· GenBank· DDBJ | Genomic DNA |