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C7TQ59 · C7TQ59_MOUSE

  • Protein
    Voltage-dependent L-type calcium channel subunit alpha
  • Gene
    Cacna1c
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

Features

Showing features for binding site.

121692004006008001,0001,2001,4001,6001,8002,000
TypeIDPosition(s)Description
Binding site393Ca2+ (UniProtKB | ChEBI)
Binding site736Ca2+ (UniProtKB | ChEBI)
Binding site1145Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentdendrite
Cellular Componentperikaryon
Cellular Componentpostsynaptic density membrane
Cellular ComponentT-tubule
Cellular Componentvoltage-gated calcium channel complex
Molecular Functionmetal ion binding
Molecular Functionvoltage-gated calcium channel activity
Biological Processsystem process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Voltage-dependent L-type calcium channel subunit alpha

Gene names

    • Name
      Cacna1c

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • C57BL/6N
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    C7TQ59

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane, sarcolemma
; Multi-pass membrane protein
Cell projection, dendrite
Membrane
; Multi-pass membrane protein
Perikaryon
Postsynaptic density membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane158-175Helical
Transmembrane195-215Helical
Transmembrane227-245Helical
Transmembrane298-320Helical
Transmembrane379-400Helical
Transmembrane412-434Helical
Transmembrane555-573Helical
Transmembrane681-703Helical
Transmembrane757-783Helical
Transmembrane931-950Helical
Transmembrane962-984Helical
Transmembrane1004-1027Helical
Transmembrane1048-1081Helical
Transmembrane1173-1199Helical
Transmembrane1250-1267Helical
Transmembrane1279-1301Helical
Transmembrane1389-1412Helical
Transmembrane1482-1506Helical

Keywords

PTM/Processing

Features

Showing features for glycosylation.

TypeIDPosition(s)Description
Glycosylation358N-linked (GlcNAc...) asparagine

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-27Disordered
Region103-128Disordered
Region479-511Disordered
Compositional bias794-839Basic and acidic residues
Region794-891Disordered
Compositional bias856-872Basic and acidic residues
Domain1640-1674Voltage-dependent calcium channel alpha-1 subunit IQ
Region1762-1803Disordered
Region1970-1996Disordered
Compositional bias1977-1992Pro residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,169
  • Mass (Da)
    243,507
  • Last updated
    2009-10-13 v1
  • MD5 Checksum
    1B6BDFD1AB3CF713CEB5E4E5E1A1475C
MIRAFVQPSTPPYQPLSSHSSEETERKFKGKVVHEAQLNCFYISPGGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGGTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEDKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEVMEKPAVEESKEEKIELKSITADGESPPTTKINMDDLQPSENEDKSPHSNPDTAGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVTYYQSDSRGNFPQTFATQRPLHINKTGNNQADTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRFPHPAGYSSTVSTVEGHGPPLSPAVRVQEAAWKLSSKRCHSRESQGATVNQEIFPDETRSVRMSEEAEYCSEPSLLSTDMFSYQEDEHRQLTCPEEDKREIQPSPKRSFLRSASLGRRASFHLECLKRQKDQGGDISQKTALPLHLVHHQALAVAGLSPLLQRSHSPTTFPRPCPTPPVTPGSRGRPLRPIPTLRLEGAESSEKLNSSFPSIHCSSWSEETTACSGSSSMARRARPVSLTVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMENAADNILSGGAQQSPNGTLLPFVNCRDPGQDRAVAPEDESCAYALGRGRSEEALADSRSYVSNL

Computationally mapped potential isoform sequences

There are 20 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q01815CAC1C_MOUSECacna1c2139
A0A668KLV2A0A668KLV2_MOUSECacna1c255
A0A1W2P6T3A0A1W2P6T3_MOUSECacna1c1969
A0A1W2P6Z7A0A1W2P6Z7_MOUSECacna1c2005
A0A1W2P731A0A1W2P731_MOUSECacna1c2063
C7TQ57C7TQ57_MOUSECacna1c2169
A0A1W2P805A0A1W2P805_MOUSECacna1c1980
F8WJL1F8WJL1_MOUSECacna1c2139
A0A087WPP1A0A087WPP1_MOUSECacna1c2167
A0A087WPZ8A0A087WPZ8_MOUSECacna1c2139
A0A087WR02A0A087WR02_MOUSECacna1c2139
A0A087WQJ4A0A087WQJ4_MOUSECacna1c2156
A0A087WQT9A0A087WQT9_MOUSECacna1c2135
A0A087WS40A0A087WS40_MOUSECacna1c2153
A0A087WS67A0A087WS67_MOUSECacna1c2164
A0A087WRM3A0A087WRM3_MOUSECacna1c2187
A0A087WSE7A0A087WSE7_MOUSECacna1c2194
A0A087WRZ6A0A087WRZ6_MOUSECacna1c2159
Q0PCR6Q0PCR6_MOUSECacna1c2169
F7C376F7C376_MOUSECacna1c2222

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias794-839Basic and acidic residues
Compositional bias856-872Basic and acidic residues
Compositional bias1977-1992Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FM872411
EMBL· GenBank· DDBJ
CAS06714.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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