C7GLT4 · SEC11_YEAS2

Function

function

Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).
Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).

Catalytic activity

  • Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.
    EC:3.4.21.89 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

116720406080100120140160
TypeIDPosition(s)Description
Active site44Charge relay system
Active site83Charge relay system
Active site109Charge relay system

GO annotations

AspectTerm
Cellular Componentsignal peptidase complex
Molecular Functionserine-type endopeptidase activity
Biological Processsignal peptide processing

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Signal peptidase complex catalytic subunit SEC11
  • EC number
  • Alternative names
    • Secretory protein 11
    • Signal peptidase I

Gene names

    • Name
      SEC11
    • ORF names
      C1Q_01195

Organism names

Accessions

  • Primary accession
    C7GLT4

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass type II membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-9Cytoplasmic
Transmembrane10-30Helical; Signal-anchor for type II membrane protein
Topological domain31-167Lumenal

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00004123561-167Signal peptidase complex catalytic subunit SEC11
Glycosylation121N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Interaction

Subunit

Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity).
The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity).
SPC associates with the translocon complex (By similarity).

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region153-164C-terminal short (CTS) helix

Domain

The C-terminal short (CTS) helix is essential for catalytic activity. It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates.

Sequence similarities

Belongs to the peptidase S26B family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    167
  • Mass (Da)
    18,762
  • Last updated
    2009-10-13 v1
  • Checksum
    FC877232D6888DF3
MNLRFELQKLLNVCFLFASAYMFWQGLAIATNSASPIVVVLSGSMEPAFQRGDILFLWNRNTFNQVGDVVVYEVEGKQIPIVHRVLRQHNNHADKQFLLTKGDNNAGNDISLYANKKIYLNKSKEIVGTVKGYFPQLGYITIWISENKYAKFALLGMLGLSALLGGE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ACFL01000039
EMBL· GenBank· DDBJ
EEU08253.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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