C7G0B5 · PIF_PINFU

Function

function

Essential component of the organic matrix for normal growth of the nacreous layer. The complex contributes to the initiation of aragonite crystallization as well as subsequenct stacking of aragonite tablets in the nacreous layer.
Pif80 binds to both aragonite and calcite crystals, with a higher specificity to aragonite crystals.
Pif97 contains a chitin-binding domain that allows for attachment of the entire complex to the chitin-containing organic framework.

Miscellaneous

Pif80 and Pif97 are rich in Asp. This amino-acid appears to be common to biomineral-forming organisms.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionchitin binding

Names & Taxonomy

Protein names

Organism names

Accessions

  • Primary accession
    C7G0B5

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_500050355223-547Protein Pif97
Disulfide bond296↔309
Disulfide bond352↔364
ChainPRO_5000503553548-1007Protein Pif80

Keywords

Expression

Tissue specificity

Component of conchiolin, the organic matrix of nacre. Expressed at extremely high levels in the dorsal region of the mantle, which region may be responsible for the nacreous layer formation, but only in trace amounts at the mantle edge, which region may be responsible for the prismatic layer formation.

Interaction

Subunit

Heterooligomer; disulfide-linked. Pif97, Pif80, N16 and other proteins form a complex.

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain29-202VWFA
Region212-244Disordered
Domain255-372Chitin-binding type-2
Compositional bias377-396Acidic residues
Region377-401Disordered
Region544-547Kex2-like proteinase cleavage site
Compositional bias588-627Basic and acidic residues
Region588-634Disordered
Region651-792Disordered
Compositional bias666-792Basic and acidic residues
Region854-983Disordered
Compositional bias856-875Acidic residues
Compositional bias876-983Basic and acidic residues

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    1,007
  • Mass (Da)
    115,355
  • Last updated
    2009-10-13 v1
  • Checksum
    A4C31FD25964F52B
MQVPSIRVVFLLTAVFCVGVKSDECKTADVVVNVDASDDVSDQDFDKLKRAMLMMVRGLSIDDNQIRLGMVTYGSEVCDSIPLQGDRLDLARTIRYMKKPTGPSKPFKGMGEARRMFSSRGRYNVPHITMNLGGDIVDTEVKDLMDETDKARDEDIKVMAIGLGAKVDRDEIESIAYDRDQAYFMDDEDDLIRKVKEIPDYLCKIIKAKKPKVSGGKKSKPAKKVDNGPAGKSPGFDALKQSDDKSDKAKKVEVKELCDDAEWVDGVGYGSVPTRCEDFVMCQNVSGSLRKTLKSCPFGQYWSKRQTSCVLTEDEDCSDDLCKTMLLPSREYDVSCRAYWKCEKGKSVARCCPSGMAYEPGKGCVLDLDCDEECPPKNDGDDDDDSSDEDDDDEIEYNPNCPLRPIKGHPEKFKQHTGDDNWEDFDCAPGTLFSARDCACSILGTAKKDDKNDDGGDAHKVCEPELYLPFCDDLHDYSGKETHVENEGDAVIIENGKAYFNGRAGLKIPRFSGVPYGKSVFIKMKYKEDEDDDKNKNDDDKKLRMKRDERSRKDYLKAILKRDDRKDKTDDTKGRRIIDRNDIIDDRRGRRKDDRKDGGRDDGKDGRRDDRKDNRLDDIKDKNDEPMTLISNGECDNFELNDCFEKPSIAITTGKKSAGFSVTSSEKDEVDLEIDEDKKGYLWDKEDGPDRNGKDKDRNGDRSDDRRGYYWKKKDKDDNGKDKDKKGDKSDDKKGYYWKKDKDDKNGKDKDKRRDKSDDKKSLDDIVREIERSKGNGKDDNKDDEDDDKKGWKTVSLKISNGHIRGRRDDREDKDVLDGDLKTTFSGFQIGQGASNKNFKGYMDEVYIYFCDPGKEADYDDEDDDDDDDDSDENDKNDDKKDGKKTDDKDKKDRKDGRDDRKDGRDDRKDRRDDRKDDRKGGKDDRKDDRKGGKDDRKDGRDVRDDRDRGDKYDKKDDKDNDRLSDKDDRKDVDDNDKDDDNEKLYKRAMKKCDYVNKNVAKWLDKR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias377-396Acidic residues
Compositional bias588-627Basic and acidic residues
Compositional bias666-792Basic and acidic residues
Compositional bias856-875Acidic residues
Compositional bias876-983Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB236929
EMBL· GenBank· DDBJ
BAH97338.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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