C6ZII9 · C6ZII9_RAT

  • Protein
    NAD-dependent protein deacetylase
  • Gene
    Sirt3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

NAD-dependent protein deacetylase.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

132050100150200250300
TypeIDPosition(s)Description
Binding site67-71NAD+ (UniProtKB | ChEBI)
Binding site77-79NAD+ (UniProtKB | ChEBI)
Binding site149-152NAD+ (UniProtKB | ChEBI)
Active site169Proton acceptor
Binding site177Zn2+ (UniProtKB | ChEBI)
Binding site180Zn2+ (UniProtKB | ChEBI)
Binding site201Zn2+ (UniProtKB | ChEBI)
Binding site204Zn2+ (UniProtKB | ChEBI)
Binding site241-242NAD+ (UniProtKB | ChEBI)
Binding site265-267NAD+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrion
Cellular Componentnucleus
Cellular Componentprotein-containing complex
Molecular Functionenzyme binding
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent histone deacetylase activity
Molecular FunctionNAD-dependent protein lysine deacetylase activity
Molecular Functionprotein lysine deacetylase activity
Molecular Functionsequence-specific DNA binding
Molecular Functiontransferase activity
Molecular Functionzinc ion binding
Biological Processaerobic respiration
Biological Processnegative regulation of ERK1 and ERK2 cascade
Biological Processnegative regulation of peptidyl-lysine acetylation
Biological Processnegative regulation of reactive oxygen species metabolic process
Biological Processpositive regulation of ceramide biosynthetic process
Biological Processpositive regulation of insulin secretion
Biological Processpositive regulation of mitochondrial transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacetylase
  • EC number

Gene names

    • Name
      Sirt3

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • W
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    C6ZII9

Organism-specific databases

PTM/Processing

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain39-301Deacetylase sirtuin-type

Sequence similarities

Belongs to the sirtuin family. Class I subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    320
  • Mass (Da)
    35,000
  • Last updated
    2009-09-22 v1
  • Checksum
    87249DD55EDB575C
MALSCRLVLAALRLWGPGGGRRPISLSVGASGGFGCGGHSEKKLSLQDVAELLRTRACSRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFTLAKELYPGHYRPNVAHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGSFVSATCTVCRRSFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHVADFALADLLLILGTSLEVEPFASLSESVQKSVPRLLINRDLVGSFALSPRRKDVVQLGDVVQGVERLVDLLGWTQELQDLIQRENGKLDGQDG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU886468
EMBL· GenBank· DDBJ
ACJ70657.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp