C6XKL4 · C6XKL4_HIRBI

Function

function

Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.

Catalytic activity

  • Endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions.
    EC:3.1.26.12 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per homotetramer.

Features

Showing features for binding site.

1904100200300400500600700800900
TypeIDPosition(s)Description
Binding site383Mg2+ (UniProtKB | ChEBI); catalytic
Binding site426Mg2+ (UniProtKB | ChEBI); catalytic
Binding site484Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site487Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoplasmic side of plasma membrane
Molecular Functionmagnesium ion binding
Molecular Functionribonuclease E activity
Molecular FunctionRNA endonuclease activity
Molecular FunctionrRNA binding
Molecular FunctiontRNA binding
Molecular Functionzinc ion binding
Biological ProcessmRNA catabolic process
Biological ProcessrRNA processing
Biological ProcesstRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease E
  • EC number
  • Short names
    RNase E

Gene names

    • Name
      rne
    • Ordered locus names
      Hbal_1895

Organism names

Accessions

  • Primary accession
    C6XKL4

Proteomes

Subcellular Location

Cytoplasm
Cell inner membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Homotetramer formed by a dimer of dimers.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain38-199S1 motif
Region95-167Disordered
Compositional bias101-110Acidic residues
Compositional bias133-149Acidic residues
Compositional bias155-167Basic residues
Region484-487Required for zinc-mediated homotetramerization and catalytic activity
Region586-904Disordered
Compositional bias608-619Acidic residues
Compositional bias623-636Basic residues
Compositional bias650-662Acidic residues
Compositional bias671-682Basic residues
Compositional bias709-720Acidic residues
Compositional bias739-750Basic residues
Compositional bias757-767Polar residues
Compositional bias771-789Basic and acidic residues
Compositional bias816-834Basic and acidic residues
Compositional bias851-863Basic and acidic residues
Compositional bias893-904Basic residues

Sequence similarities

Belongs to the RNase E/G family. RNase E subfamily.
Belongs to the RNase E/G family. RNase G subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    904
  • Mass (Da)
    100,509
  • Last updated
    2009-09-22 v1
  • MD5 Checksum
    6A0D07DB35411486F96176CA7EEF6C09
MSKLMLIDAAHPEETRVTVVADGQIEDFDFEARDKRQLRGNIYLAKVTRVEPSLQAAFVEYGGNRHGFLAFSEIHPDYYQIPKEDREALLAETMASSRHDDDDDVDEEDTVEHNHDSEDSSEENSETENLSSEGDDTLIDEDTDSSSDDDNAKQRAPKPRHQKPSRRYKIQEVIKRRQVLLIQVVKEERGNKGAAVTTYLSLAGRYGVLMPNTARGGGISRKIANAADRKRLKKIMGEFSVPEGMGLIIRTAGAKRTKSEISRDYDYLIRLWSTIRDQTLDSMAPCLIHEEGDLVLRAIRDLYDRDIDNIIVEGKEAYVQAKNVISMLMPDHAEKVIEHNHKAPLFISQAVEAQLDNIFSPVVQLPSGGYLVINQTEALVAVDVNSGKATRERNIEATAVKTNLEAAAEVCRQMRLRDLAGLVVIDFIDMEESKNNRAVEKKMKDCLSIDRARVQTGRISQFGLFEISRQRRRAGVLELSSEPCKACQGTGRNRSIESAALQLLRAIEERGADGRVDSVAAKAPSEVALYILNHKRDSITSMEASTGADILISADDEMMPGDFAIEATGDGNIIAYKPIVPIDATPKKRRRRRPEEDEEAVDNSEQNDTSDEEDDDELDENSRRRRRGRRGGRRRRGNETGSEVSADGMEVIDGDSEEESEDTNNSSNASKSRRPRRRRPRRRTPDVAMDGGEMLDAVASAPFLAIVSPEEEEDEAEQEVTAESQSNSEDNNSENGRSRNGKRRRRRRKNGNTDTNESNTSEESQAIASDVSKEETVEASTKEEAKPAETEVPAPTMSEPTTDVSHEANDASTPLTKEEPAKSESDSETSKSDESSSEPKNLEEAPVEPVAEVKIDAPAKAETAETEPAPAEETASLHSLHANTSTIAEEKAPKKRKIGWWNRK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias101-110Acidic residues
Compositional bias133-149Acidic residues
Compositional bias155-167Basic residues
Compositional bias608-619Acidic residues
Compositional bias623-636Basic residues
Compositional bias650-662Acidic residues
Compositional bias671-682Basic residues
Compositional bias709-720Acidic residues
Compositional bias739-750Basic residues
Compositional bias757-767Polar residues
Compositional bias771-789Basic and acidic residues
Compositional bias816-834Basic and acidic residues
Compositional bias851-863Basic and acidic residues
Compositional bias893-904Basic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001678
EMBL· GenBank· DDBJ
ACT59581.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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