C6KTF7 · C6KTF7_PLAF7
- ProteinErythrocyte membrane protein 1, PfEMP1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids3954 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell plasma membrane | |
Cellular Component | infected host cell surface knob | |
Cellular Component | membrane | |
Molecular Function | cell adhesion molecule binding | |
Molecular Function | host cell surface receptor binding | |
Biological Process | adhesion of symbiont to microvasculature | |
Biological Process | antigenic variation | |
Biological Process | cell-cell adhesion | |
Biological Process | modulation by symbiont of host erythrocyte aggregation |
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)
Accessions
- Primary accessionC6KTF7
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 183 | PTMeXchange | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 15-50 | Plasmodium falciparum erythrocyte membrane protein-1 N-terminal segment | ||||
Sequence: SVKDLFDRIGKEVHDQVEKEANQYKEALKGDLSSAT | ||||||
Domain | 114-310 | Duffy-antigen binding | ||||
Sequence: GFCAPYRRLHLCVQNLEQIKPDQITSTHNLLVDVLLAAKYEGQSITQDYPKYQATYDDSPSKMCTMLARSFADIGDIVRGKDLFLGTNEEKKPLEENLKEIFKKIYENLGIQEKNHYNDTPDYYKLREDWWIANRDQVWKAITCNAGGYSYFRKTCGGDNEKNSTLASNKCRCKDEKGEHDTDQVPTYFDYVPQYLR | ||||||
Domain | 314-472 | Duffy-binding-like | ||||
Sequence: EWAEDFCRKKKIKVENVKKSCRGEDKESKDRYCSRNGYDCEKTKRAIGKLRYGKQCISCLYGCNPYVDWIEKQKEQFDKQKKIYDKEIKKYENGASSSSRKTRAASTTNYEEYEKKFYEELNKSEYSDVNAFLEKLSKEDVCTKVQDDKGGRISFENVK | ||||||
Region | 469-499 | Disordered | ||||
Sequence: ENVKSSSASGGAAGTSSTSGGGTSGDSGTNN | ||||||
Domain | 652-810 | Duffy-binding-like | ||||
Sequence: FFYYWVAHMLKDSIHWKKKLQRCLEKKNGNTCKKNNCKDNCGCFEKWVAQKKEQEWDPIKQQFRKQDFGKQELILGQIRYDYVLDELLKKDELLTSIKEGYGDANEIKHIKALLEDEENEETQEEETAGADNQKKNTIDWLIQHEEDDAELCLEIHEDE | ||||||
Domain | 938-1112 | Duffy-antigen binding | ||||
Sequence: VFLPPRRQHMCTSNLENLDVDSVTENDKASHSLLGDVQLAAKTDAAEIIKRYKDQNNIQLTDPIQQKDQEAMCRAIRYSFADLGDIIRGRDMWNKDSGSTEMEKHLISIFEKINEKLPEKEQKKYSNDGKYLDLRKDWWEANRYKVWKAMKCATKNSKIPCSGIPIEDYIPQRLR | ||||||
Domain | 1360-1539 | Duffy-antigen binding | ||||
Sequence: GACMPPRRQSLCIHNLKESNETGTEQQLREAFINCAAIETFWLWYKYKKDKNVDAEKKLEQGEIPSEFLRSMIYTFGDYRDLCLNTDISAKKDPIKIVKNNIQKVFNRNNGPHKEGDKEKRKKFWETNKNDIWQGMLCALEKIANNKKTLTETYNYSLVKFSGNNSTTLEDFAKTPQFLR | ||||||
Compositional bias | 1732-1758 | Polar residues | ||||
Sequence: DSSNTTRSSPPAPVASSTLSTSPEAGA | ||||||
Region | 1732-1760 | Disordered | ||||
Sequence: DSSNTTRSSPPAPVASSTLSTSPEAGASA | ||||||
Domain | 1761-1933 | Duffy-antigen binding | ||||
Sequence: TCIPPRRQQMYIQPLQSLSGNESQVELRRIFIEMAAIETFFQWHKFKKEKVREIKEKDEIDGKISLFGQDDTSIEENLQKQLKNGTIPDDFKRQMFYTFGDYKDILFGKYIGIDMGTVKTNIGRVFNNGGNKSDEEREKWWKNHGPSIWNGMLCGLSYDTKTKHNIQGVYTQL | ||||||
Domain | 1974-2121 | Duffy-binding-like | ||||
Sequence: EWGEEFCKKRTDKLKKLEKECRGVNYSGYNKYCSGDGYHCDDEKGTYNSINANLNCRDCMKECRNYKTWIVKKKNEYDKQKSKYVNEHENVISFLNKQSYKQLYENIKPYSSAADFFTSLNHCKPDKANDDKNNKLNFKNPHETFSPS | ||||||
Domain | 2223-2369 | Duffy-binding-like | ||||
Sequence: LFHRWITDFIQYYNKSKEKIKPCTNDVNSCKQGCKGNCDCVDKWLKNKSTEWEIIKKYYKENFGNTNEHIAYAIKIFLQEGLFDSDYKRAQEVIDQNEWEQLWGCTGDNLKDVKDQKAENCNKGDFITNLISKLQDKITSCQNKHNP | ||||||
Region | 2368-2420 | Disordered | ||||
Sequence: NPNGKTACDEIPPHSDEEETSLLDDDTSTQEKMSPDFCPSDMPEKPKTDSDIL | ||||||
Domain | 2464-2613 | Duffy-antigen binding | ||||
Sequence: VYISPRAHQLYLEPLKDLKENNTDKNELIKAFTKCAYNEGKCLYEYYSKNKATLGKNGSALSNDEVKTYTLEAMERSYADYGTIVKEDILWDYEDKKKIDPKIMNFAKNHNISTTKTIVSSLDDDDVKRQKLWESIRIDVWKAMICGYKD | ||||||
Coiled coil | 2686-2713 | |||||
Sequence: CKNYREFLNNFKKQYENQKKEYEIIKSS | ||||||
Domain | 2816-2951 | Duffy-antigen binding | ||||
Sequence: LIPPRRRHLCLRNIIIKKNYRKGDISKFKDDLFYAAASEAKFLFNNYENKNESLQAIKYTFADIGDIIKGNDMMDDMTYKKIKGKLEKVLDKTGNNPETPEKWWEQNKKHVWEAMLCGYKLAGGEIKPNDCNIPTE | ||||||
Domain | 3143-3286 | Duffy-antigen binding | ||||
Sequence: GVLVPPRRRHLCLRIDVNKFLRLRNDINNLKTFICKSAFAEAKRLKKVYKDDNSKLHQAMKYSFSDIGSVVKGNDMMESPTSDNIAKIFRGMKYTEINRETWWDLNKYHVWESMLCGYREAGGDTKKSENCRFPDIERVPQFLR | ||||||
Region | 3411-3431 | Disordered | ||||
Sequence: EVKPKKPAVPEAKKPEVEPLP | ||||||
Domain | 3444-3954 | Plasmodium falciparum erythrocyte membrane protein 1 acidic terminal segment | ||||
Sequence: TIPFGVALALGSIAFLFLKKKTQAPVDLFSVINIPKGDHDIPTLKSSNRYIPYVSDRYKGKTYIYMEGDSDSGHYYEDTTDITSSESEYEELDINDIYPYKSPKYKTLIEVVLEPSGNNTPTSDTPSDTQNDIPSGDTPNNKLTDNEWNTLKDEFISQYIQSEQPNDVPNDYTSGNSSTNTNITTTSRHNVEEKPFIMSIHDRNLYTGEEYNYDMSTNSGNNDLYNGKNNLYSGQNNVYSGIDPTSDNRGPYSDKNDRISDNHHPYSGIDLINDTLSGNAHIDIYDELLKRKENELFGTNHVKHTSTHSVAKHTNSDPIHNQLNLFHTWLDRHRDMCEKWNTKEELLDKLNEQWNKDNNNSGNINPSGNTPPTSDIPSGKLSDIPSDNNIHSDIPYVLNTDVSIQIDMNNPKTTNEFTYVDSNPNQVDDTYVDSNPDNSSMDTILEDLDKPFNEPYYYDMYDDDIYYDVHDHDTSTVDTNAMDVPSKVQIEMDVNTKLVKEKYPISDVWDI | ||||||
Region | 3558-3589 | Disordered | ||||
Sequence: PSGNNTPTSDTPSDTQNDIPSGDTPNNKLTDN | ||||||
Region | 3608-3627 | Disordered | ||||
Sequence: PNDVPNDYTSGNSSTNTNIT | ||||||
Region | 3800-3830 | Disordered | ||||
Sequence: DNNNSGNINPSGNTPPTSDIPSGKLSDIPSD |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,954
- Mass (Da)456,918
- Last updated2009-09-01 v1
- Checksum374626667C675F8B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1732-1758 | Polar residues | ||||
Sequence: DSSNTTRSSPPAPVASSTLSTSPEAGA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL844505 EMBL· GenBank· DDBJ | CAG25137.1 EMBL· GenBank· DDBJ | Genomic DNA |