C6KF54 · C6KF54_HBOC2
- ProteinMinor capsid protein VP1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids667 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Capsid proteins self-assembles to form an icosahedral capsid with a T=1 symmetry, about 26 nm in diameter, and consisting of 60 copies of three size variants of the capsid proteins, VP1, and VP3, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid has a channel at the 5-fold axis and there are densities extending the 5-fold axis into the interior of the capsid. The capsid encapsulates the genomic ssDNA. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region. The additional N-terminal region of isoform Minor capsid protein VP1, called VP1u, may serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | host cell cytoplasm | |
Cellular Component | host cell nucleus | |
Cellular Component | T=1 icosahedral viral capsid | |
Molecular Function | phospholipase A2 activity | |
Molecular Function | structural molecule activity | |
Biological Process | lipid catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMinor capsid protein VP1
- EC number
Organism names
- Strain
- Taxonomic lineageViruses > Monodnaviria > Shotokuvirae > Cossaviricota > Quintoviricetes > Piccovirales > Parvoviridae > Parvovirinae > Bocaparvovirus > Bocaparvovirus primate2
- Virus hosts
Accessions
- Primary accessionC6KF54
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 10-88 | Phospholipase A2-like | ||||
Sequence: GWVLPGYKYLGPFNPLENGEPVNKADRAAQAHDKSYSEIIKSGKNPYLYFNKADEKFIDDLKNDWSLGGIIGSSFFKLK | ||||||
Region | 107-159 | Disordered | ||||
Sequence: YFANSNKGAKKPKNNEPKPGTSKMSENEIQDQQPSGSMEERGGGGGAVGSVGG | ||||||
Compositional bias | 124-143 | Polar residues | ||||
Sequence: KPGTSKMSENEIQDQQPSGS | ||||||
Domain | 158-372 | Parvovirus coat protein VP2 | ||||
Sequence: GGGKGSGVGISTGGWVGGSYFTDSYVITKNTRQFLVKIQNDHKYRTENIIPSNAGGKSQRCVSTPWSYFNFNQYSSHFSPQDWQRLTNEYKRFKPRKMHVKIYNLQIKQILSNGADTTYNNDLTAGVHIFCDGEHAYPNATHPWDEDVMPELPYETWYLFQYGYIPVIHELAEMEDANAVEKAIALQIPFFMLENSDHEVLRTGESTEFTFDFDC | ||||||
Domain | 528-621 | Parvovirus coat protein VP2 | ||||
Sequence: FPNQIWDRYPITRENPIWCKKPRSDKNTIIDPFDGTLAMDHPPGTIFIKMAKIPVPSNNNADSYLNIYCTGQVSCEIVWEVERYATKNWRPERR |
Sequence similarities
Belongs to the parvoviridae capsid protein family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length667
- Mass (Da)74,926
- Last updated2009-09-01 v1
- ChecksumA28D6017426D5ED6
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 124-143 | Polar residues | ||||
Sequence: KPGTSKMSENEIQDQQPSGS |