C6KEM4 · AADH2_MAIZE

  • Protein
    Aminoaldehyde dehydrogenase 2
  • Gene
    AMADH2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Dehydrogenase that catalyzes the oxidation of several aminoaldehydes (PubMed:23408433).
Metabolizes and detoxifies aldehyde products of polyamine degradation to non-toxic amino acids (Probable). Catalyzes the oxidation of 4-aminobutanal and 3-aminopropanal to 4-aminobutanoate and beta-alanine, respectively (PubMed:23408433).
Catalyzes the oxidation of 4-(trimethylamino)butanal and 4-guanidinobutanal to 4-trimethylammoniobutanoate and 4-guanidinobutanoate, respectively (PubMed:23408433).

Catalytic activity

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
59 μM4-aminobutanal
98 μM3-aminopropanal
16 μM4-(trimethylamino)butanal
11 μM4-guanidinobutanal
86 μMNAD+ with 3-aminopropanal as substrate

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site101Na+ (UniProtKB | ChEBI)
Binding site161-163NAD+ (UniProtKB | ChEBI)
Site164Transition state stabilizer
Binding site187-190NAD+ (UniProtKB | ChEBI)
Binding site191Na+ (UniProtKB | ChEBI)
Binding site241-244NAD+ (UniProtKB | ChEBI)
Active site262Proton acceptor
Binding site262NAD+ (UniProtKB | ChEBI)
Active site297Nucleophile
Binding site396NAD+ (UniProtKB | ChEBI)
Binding site462NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentperoxisome
Molecular Function4-trimethylammoniobutyraldehyde dehydrogenase activity
Molecular Functionaminobutyraldehyde dehydrogenase activity
Molecular Functionbetaine-aldehyde dehydrogenase activity
Molecular Functiongamma-guanidinobutyraldehyde dehydrogenase activity
Molecular Functionprotein homodimerization activity
Molecular Functionsodium ion binding
Biological Processcellular detoxification of aldehyde
Biological Processcellular response to anoxia
Biological Processglycine betaine biosynthetic process from choline

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aminoaldehyde dehydrogenase 2
  • EC number
  • Short names
    ZmAMADH2
  • Alternative names
    • 4-trimethylammoniobutyraldehyde dehydrogenase AMADH2
      (EC:1.2.1.47
      ) . EC:1.2.1.47 (UniProtKB | ENZYME | Rhea)
    • Aminobutyraldehyde dehydrogenase AMADH2
      (EC:1.2.1.19
      ) . EC:1.2.1.19 (UniProtKB | ENZYME | Rhea)
    • Gamma-guanidinobutyraldehyde dehydrogenase AMADH2
      (EC:1.2.1.54
      ) . EC:1.2.1.54 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      AMADH2
    • Synonyms
      ALDH10A5
    • ORF names
      ZEAMMB73_Zm00001d025626

Organism names

  • Taxonomic identifier
  • Strain
    • cv. B73
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > PACMAD clade > Panicoideae > Andropogonodae > Andropogoneae > Tripsacinae > Zea

Accessions

  • Primary accession
    C6KEM4
  • Secondary accessions
    • A0A1D6J865
    • B4G044
    • B6SWI7

Proteomes

Genome annotation databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004541371-506Aminoaldehyde dehydrogenase 2

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    506
  • Mass (Da)
    54,862
  • Last updated
    2022-02-23 v2
  • Checksum
    8033CB10EF67B5A3
MAPPQTIPRRGLFIGGAWREPCLGRRLPVVNPATEATIGDIPAGTAEDVEIAVAAARDAFSRDGGRHWSRAPGAVRANFLRAIAAKIKDRKSELALLETLDSGKPLDEASGDMDDVAACFEYYADLAEALDGKQQSPISLPMENFKSYVLKEPIGVVGLITPWNYPLLMATWKVAPALAAGCTTILKPSELASVSCLELGAICMEIGLPPGVLNIITGLGPEAGAPLSSHSHVDKVAFTGSTETGKRIMISAAQMVKPVSLELGGKSPLIVFDDIGDIDKAVEWTMFGIFANAGQVCSATSRLLLHEKIAKKFLDRLVAWAKNIKVSDPLEEGCRLGSVISEGQYEKIKKFISTARSEGATILYGGGRPQHLRRGFFLEPTIITDVSTSMQIWQEEVFGPVICVKEFRTESEAVELANDTHYGLAGAVISNDQERCERISKALHSGIIWINCSQPCFVQAPWGGNKRSGFGRELGEWGLDNYLTVKQVTKYCSDEPWGWYQPPSKL

Sequence caution

The sequence AQK44109.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict67in Ref. 1; ACS74868
Sequence conflict135in Ref. 1; ACS74868
Sequence conflict202in Ref. 3; ACG29220
Sequence conflict250in Ref. 1; ACS74868 and 3; ACG29220
Sequence conflict274in Ref. 3; ACG29220
Sequence conflict410in Ref. 1; ACS74868
Sequence conflict442in Ref. 3; ACG29220

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ184594
EMBL· GenBank· DDBJ
ACS74868.1
EMBL· GenBank· DDBJ
mRNA
CM000786
EMBL· GenBank· DDBJ
AQK44108.1
EMBL· GenBank· DDBJ
Genomic DNA
CM000786
EMBL· GenBank· DDBJ
AQK44109.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
EU957102
EMBL· GenBank· DDBJ
ACG29220.1
EMBL· GenBank· DDBJ
mRNA
BT042732
EMBL· GenBank· DDBJ
ACF87737.1
EMBL· GenBank· DDBJ
mRNA
BT067636
EMBL· GenBank· DDBJ
ACN34533.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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