C6E6N2 · PYRDB_GEOSM

  • Protein
    Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit
  • Gene
    pyrD
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of dihydroorotate to orotate with NAD+ as electron acceptor.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD+ route): step 1/1.

Features

Showing features for binding site, active site.

130520406080100120140160180200220240260280300
Type
IDPosition(s)Description
Binding site23FMN (UniProtKB | ChEBI)
Binding site47substrate
Binding site47-48FMN (UniProtKB | ChEBI)
Binding site71-75substrate
Binding site101FMN (UniProtKB | ChEBI)
Binding site129FMN (UniProtKB | ChEBI)
Binding site129substrate
Active site132Nucleophile
Binding site167FMN (UniProtKB | ChEBI)
Binding site193FMN (UniProtKB | ChEBI)
Binding site194-195substrate
Binding site219FMN (UniProtKB | ChEBI)
Binding site245-246FMN (UniProtKB | ChEBI)
Binding site267-268FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiondihydroorotate dehydrogenase (NAD+) activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit
  • EC number
  • Short names
    DHOD B; DHODase B; DHOdehase B
  • Alternative names
    • Dihydroorotate oxidase B
    • Orotate reductase (NADH)

Gene names

    • Name
      pyrD
    • Ordered locus names
      GM21_1820

Organism names

  • Taxonomic identifier
  • Strain
    • M21
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Desulfuromonadia > Geobacterales > Geobacteraceae > Geobacter

Accessions

  • Primary accession
    C6E6N2

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10002043061-305Dihydroorotate dehydrogenase B (NAD+), catalytic subunit

Interaction

Subunit

Heterotetramer of 2 PyrK and 2 PyrD type B subunits.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    305
  • Mass (Da)
    31,883
  • Last updated
    2009-09-01 v1
  • MD5 Checksum
    7B503B98240A1D4AF4C231112814720A
MQRPDMSVAVAGIKMRNPVMTASGTFGYGAEFADYLDLESIGAMISKGLSLKPKAGNPTPRIVETPGGMLNAIGLQNVGIDAFIEQKLPYLKNVNTPVIVNLYGNTLEEYGEVAARLDGLAGVAGIEVNISCPNVKQGGIVFGTDPGAAQEVVRLVKKNTSKPMIVKLSPNVTDVVVMAKACADAGADALSLINTLTGMAIDLERRRPVLANVTGGLSGPAIKPVALRMVWQVGKAVKLPLIGIGGIMNGRDALEFMLAGATAVQVGTASFLDPSAAQRIAREMEQYLADHNIESVSSLIGALEL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001661
EMBL· GenBank· DDBJ
ACT17873.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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