C6C1T6 · KATG_MARSD
- ProteinCatalase-peroxidase
- GenekatG
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids727 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
Catalytic activity
- AH2 + H2O2 = A + 2 H2O
Cofactor
Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
Features
Showing features for site, active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | catalase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | hydrogen peroxide catabolic process | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCatalase-peroxidase
- EC number
- Short namesCP
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Thermodesulfobacteriota > Desulfovibrionia > Desulfovibrionales > Desulfovibrionaceae > Maridesulfovibrio
Accessions
- Primary accessionC6C1T6
Proteomes
PTM/Processing
Features
Showing features for chain, cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000216222 | 1-727 | Catalase-peroxidase | |||
Sequence: MSDEKKCPVTGRTSSQVAGSGTSNKDWWPNQLNLNILHQHSAKSDPMGKDFNYAEEFKKLDLEALKKDLFELMTDSQDWWPADYGHYGPFFIRMAWHSAGTYRIGDGRGGAGSGSQRLAPLNSWPDNVNLDKARRLLWPIKKKYGRKISWADLMIFAGNCAIESMGLKPFGFAGGREDIWEPEEDIYWGDEDTWLGDTRYSGDRKLDNPLAAVQMGLIYVNPEGPNGDPNAVASGKDVRETFARMAMNDEETVALVAGGHTFGKCHGAGDAANVGPDPEGAPIEQQGLGWKSKFGSGKGGDTISSGIEGAWTPTPIKWDNSYFDTLFGYEWNLEKSPAGAWQWHPSDPEAKKAVPDAHDPSKTHPPMMTTADLSLRMDPIYAPIAKRFHENPEEFADAFARAWFKLTHRDMGPRARYLGSMVPDEELIWQDPVPAVDHELIDNTEIADLKAKILASGLSISKLVSAAWASASTYRDSDKRGGSNGARIRLAPQKDWYVNQPLQLPELLNKLEEIQQHFNSKSGNKKVSLADLIVLGGCAAVEQGAKNAGFDVTVPFTPGRTDASQEQTDVHSFAVLEPAADGFRNYQKVKYSVTPEELLVDKAQLMTLTAPEMTVLIGGMRVLDANFDGSKHGVFTDKPGSLNNDFFSNLLDMDTVWTSTSEDAELFEGRDRESGELKWSATRIDLIFGANSQLRAIAEVYGCEDSGEKFVNDFISAWDKVMNLGIF | ||||||
Cross-link | 96↔219 | Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-245) | ||||
Sequence: WHSAGTYRIGDGRGGAGSGSQRLAPLNSWPDNVNLDKARRLLWPIKKKYGRKISWADLMIFAGNCAIESMGLKPFGFAGGREDIWEPEEDIYWGDEDTWLGDTRYSGDRKLDNPLAAVQMGLIY | ||||||
Cross-link | 219↔245 | Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-96) | ||||
Sequence: YVNPEGPNGDPNAVASGKDVRETFARM |
Post-translational modification
Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-26 | Disordered | ||||
Sequence: MSDEKKCPVTGRTSSQVAGSGTSNKD | ||||||
Compositional bias | 7-26 | Polar residues | ||||
Sequence: CPVTGRTSSQVAGSGTSNKD | ||||||
Region | 346-365 | Disordered | ||||
Sequence: SDPEAKKAVPDAHDPSKTHP |
Sequence similarities
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length727
- Mass (Da)80,299
- Last updated2009-09-01 v1
- Checksum003B3CF4A23E37CF
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 7-26 | Polar residues | ||||
Sequence: CPVTGRTSSQVAGSGTSNKD |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001649 EMBL· GenBank· DDBJ | ACS79332.1 EMBL· GenBank· DDBJ | Genomic DNA |