C6A3T5 · MVK_THESM

Function

function

Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site109-119ATP (UniProtKB | ChEBI)
Active site160Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionmevalonate kinase activity
Biological Processisopentenyl diphosphate biosynthetic process, mevalonate pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mevalonate kinase
  • EC number
  • Short names
    MK
    ; MVK

Gene names

    • Name
      mvk
    • Ordered locus names
      TSIB_1226

Organism names

Accessions

  • Primary accession
    C6A3T5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10002042281-333Mevalonate kinase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    333
  • Mass (Da)
    35,408
  • Last updated
    2009-09-01 v1
  • Checksum
    5D70B6352D620BB1
MRVLASAPAKIILFGEHSVVYGKPAIAAAIDLRTYVKAEFNENGRIRIEAKDIRTPGLTVSFSEDQIYFETDYGKAAEVLSYVREAINLVMEEAEKQKGVTVSITSQIPVGAGLGSSAAVAVATIGAVSRLFGLELTPEEVAKLGHKVELLVQGASSGIDPTVSAIGGFLYYQKGSFESLPVVELPIVVGYTGSSGSTKELVAKVRKNYEEMPEIIDPILNSMGRLVEKAREVILAEYDKEIKFKRLGTLMNINHGLLDALGVSTKSLSDLVYASREAGALGAKITGAGGGGCMYALAPEKQSEVATAIKIAGGMPIVTKISREGLRIEDIVQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001463
EMBL· GenBank· DDBJ
ACS90280.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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