C6A3T5 · MVK_THESM
- ProteinMevalonate kinase
- Genemvk
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids333 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
Catalytic activity
- (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H+
Cofactor
Pathway
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | mevalonate kinase activity | |
Biological Process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMevalonate kinase
- EC number
- Short namesMK ; MVK
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Thermococci > Thermococcales > Thermococcaceae > Thermococcus
Accessions
- Primary accessionC6A3T5
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000204228 | 1-333 | Mevalonate kinase | |||
Sequence: MRVLASAPAKIILFGEHSVVYGKPAIAAAIDLRTYVKAEFNENGRIRIEAKDIRTPGLTVSFSEDQIYFETDYGKAAEVLSYVREAINLVMEEAEKQKGVTVSITSQIPVGAGLGSSAAVAVATIGAVSRLFGLELTPEEVAKLGHKVELLVQGASSGIDPTVSAIGGFLYYQKGSFESLPVVELPIVVGYTGSSGSTKELVAKVRKNYEEMPEIIDPILNSMGRLVEKAREVILAEYDKEIKFKRLGTLMNINHGLLDALGVSTKSLSDLVYASREAGALGAKITGAGGGGCMYALAPEKQSEVATAIKIAGGMPIVTKISREGLRIEDIVQ |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length333
- Mass (Da)35,408
- Last updated2009-09-01 v1
- Checksum5D70B6352D620BB1
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001463 EMBL· GenBank· DDBJ | ACS90280.1 EMBL· GenBank· DDBJ | Genomic DNA |