C5MLK8 · C5MLK8_9INFA

Function

function

Determines the virion's shape: spherical or filamentous. Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology. Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place.

Miscellaneous

Most abundant protein in virion. When expressed alone can form virus-like particles in transfected cells.

GO annotations

AspectTerm
Cellular Componenthost cell nucleus
Cellular Componentmembrane
Cellular Componentvirion membrane
Molecular FunctionRNA binding
Molecular Functionstructural constituent of virion
Biological Processviral budding from plasma membrane

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Matrix protein 1
  • Short names
    M1

Gene names

    • Name
      M1
    • Synonyms
      M

Organism names

  • Taxonomic identifier
  • Strain
    • A/chicken/East Java/UT6016/2006
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Polyploviricotina > Insthoviricetes > Articulavirales > Orthomyxoviridae > Alphainfluenzavirus > Alphainfluenzavirus influenzae > Influenza A virus

Accessions

  • Primary accession
    C5MLK8

Proteomes

Subcellular Location

Virion membrane
; Peripheral membrane protein
Host nucleus

Keywords

Interaction

Subunit

Homodimer and homomultimer. Interacts with NEP. Binds ribonucleocapsid by both interacting with genomic RNA and NP protein. May interact with HA and NA. Cannot bind NP without genomic RNA.

Family & Domains

Features

Showing features for region, motif, domain.

TypeIDPosition(s)Description
Region1-164Membrane-binding
Motif101-105Nuclear localization signal
Domain158-252Influenza matrix M1 C-terminal
Region165-252RNP-binding

Sequence similarities

Belongs to the influenza viruses Matrix protein M1 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    252
  • Mass (Da)
    27,854
  • Last updated
    2009-07-28 v1
  • Checksum
    B06DD4FF36C2C0ED
MSLLTEVETYVLSIIPSGPLKAEIAQKLEDVFAGKNADLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDKAVKLYKKLKREITFHGAKEVALSYSTGALASCMGLIYNRMGAVTTEVAFGLVCATCEQIADSQHRSHRQMATITNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVANQARQMVQAMRTIGTHPNSSAGLRDNLLENLQAYQKRMGVQMHRFK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ122500
EMBL· GenBank· DDBJ
ACR48966.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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