C5MLH1 · C5MLH1_9INFA
- ProteinNuclear export protein
- GeneNEP
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids121 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs to which the M1 protein is bound. Because the M1 protein is not available in large quantities until the later stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the nucleus before sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enters the cytoplasm only when they have associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell nucleus | |
Cellular Component | virion component | |
Biological Process | exit of virus from host cell nucleus through nuclear pore | |
Biological Process | RNA export from nucleus |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameNuclear export protein
- Short namesNEP
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Negarnaviricota > Polyploviricotina > Insthoviricetes > Articulavirales > Orthomyxoviridae > Alphainfluenzavirus > Alphainfluenzavirus influenzae > Influenza A virus
Accessions
- Primary accessionC5MLH1
Proteomes
Subcellular Location
Interaction
Subunit
Binds M1 protein. May interact with host nucleoporin RAB/HRB and exportin XPO1/CRM1.
Binds M1 protein. May interact with human nucleoporin RAB/HRB and exportin XPO1/CRM1.
Interacts with protein M1. May interact with host nucleoporin RAB/HRB and exportin XPO1/CRM1.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length121
- Mass (Da)14,377
- Last updated2009-07-28 v1
- Checksum1A787861EDC26560