C5MLH1 · C5MLH1_9INFA

Function

function

Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs to which the M1 protein is bound. Because the M1 protein is not available in large quantities until the later stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the nucleus before sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enters the cytoplasm only when they have associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.

GO annotations

AspectTerm
Cellular Componenthost cell nucleus
Cellular Componentvirion component
Biological Processexit of virus from host cell nucleus through nuclear pore
Biological ProcessRNA export from nucleus

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nuclear export protein
  • Short names
    NEP
  • Alternative names
    • Non-structural protein 2
      (NS2
      )

Gene names

    • Name
      NEP
    • Synonyms
      NS

Organism names

  • Taxonomic identifier
  • Strain
    • A/chicken/Bali/UT2092/2005
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Polyploviricotina > Insthoviricetes > Articulavirales > Orthomyxoviridae > Alphainfluenzavirus > Alphainfluenzavirus influenzae > Influenza A virus

Accessions

  • Primary accession
    C5MLH1

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Binds M1 protein. May interact with host nucleoporin RAB/HRB and exportin XPO1/CRM1.
Binds M1 protein. May interact with human nucleoporin RAB/HRB and exportin XPO1/CRM1.
Interacts with protein M1. May interact with host nucleoporin RAB/HRB and exportin XPO1/CRM1.

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif12-21Nuclear export signal
Motif85-94Nuclear export signal

Sequence similarities

Belongs to the influenza viruses NEP family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    121
  • Mass (Da)
    14,377
  • Last updated
    2009-07-28 v1
  • Checksum
    1A787861EDC26560
MDSNTVLSFQDILVRMSKMQLASSSEDLNGMITQFESLKLYRDSLGEAVMRMGDFHSLQIRNGKWREQLSQKFEEIRWLIEEVRHRLKITENSFEQITFMQALQLLLEVEQEIRAFSFQLI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GQ122476
EMBL· GenBank· DDBJ
ACR49007.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

Disclaimer

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