C5F258 · C5F258_9HELI

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site7-12substrate
Binding site43Mg2+ (UniProtKB | ChEBI)
Active site80Proton acceptor
Binding site80Mg2+ (UniProtKB | ChEBI)
Binding site81substrate
Binding site160-163substrate
Binding site183substrate
Binding site188-189substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      HPMG_01809

Organism names

  • Taxonomic identifier
  • Strain
    • MIT 98-5489
  • Taxonomic lineage
    Bacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Helicobacteraceae > Helicobacter

Accessions

  • Primary accession
    C5F258

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    208
  • Mass (Da)
    23,235
  • Last updated
    2009-07-28 v1
  • Checksum
    2B180F984E0F8BD9
MRLILATSNQDKIIEIQEIYKPFEQNALEILAWSDLCNPFEIDENGKTFQENALIKSKAVFNTLHAKNLLSQNDIILSDDSGICVDALDGKPGIHSARYSGGDSKANLEKLLCEVAKLPNQTSKAHYCASIGISSFYGDFSTHGFMYGKVIANQRGKNGFGYDPMFIPQGFTQTLAELTKEEKNAISHRYIALNRAKYILRALFKAFK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS990446
EMBL· GenBank· DDBJ
EEQ64352.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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