C5EBC7 · C5EBC7_BIFLI

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

169750100150200250300350400450500550600650
Type
IDPosition(s)Description
Binding site257-264ATP (UniProtKB | ChEBI)
Binding site479Zn2+ (UniProtKB | ChEBI); catalytic
Active site480
Binding site483Zn2+ (UniProtKB | ChEBI); catalytic
Binding site555Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • Synonyms
      hflB
    • ORF names
      BLIG_01645

Organism names

Accessions

  • Primary accession
    C5EBC7

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane53-71Helical
Transmembrane166-185Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region1-45Disordered
Domain249-388AAA+ ATPase
Region667-697Disordered
Compositional bias670-697Basic and acidic residues

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    697
  • Mass (Da)
    76,050
  • Last updated
    2009-07-28 v1
  • Checksum
    3F4C8271C9F77938
MSFPQGPGNGNNPNPDNNRNNGNPFTNPFNRGNNGTNGKGNNNENRPIWQSPWLWGAVLVVMVVLMFQMFAGGGTKTIDTKDGFALINQGKATYAEITDNKQVVRLKLKNDYTKKNADTGKVTNYGKNVQFYYTFAQGAQVAKAVENGDLEKGWTSNIEQTSMMSYLITSILPFVIVFALFWFLMSRMGGAGGMLGMGGKKNSGKLLDGQTPTTKFADVAGEDEAVAEVEEIKDFLKDPSKYKALGARIPRGVLLYGPPGTGKTLLARAIAGEAGVPFYSMAGSDFVEMFVGLGASRVRDLFDEAKKNAPAIIFIDEIDAVGRKRGSGMGGGHDEREQTLNQLLVEMDGFDNDTNLIIIAATNRPDVLDPALLRPGRFDRQVGVAAPDLEGREAILRVHAKGKPFVPDVDLHMVAVRTPGFTGADLANVLNEAALLCARAGAQLIDNRAIDEAIDRVQAGPKRKSKGMALEELRNTAYHEGGHALVAAALNNTDPVTKVTILPRGRALGYTAVMPTSDRYSQSRNQLLDQMAYAMGGRTAEEIVFHDPTTGASNDIEKATSIARTMVIEYGFSDKLGAIKWGSDDDQTTVMDGLQPRKYSDRTAEVIDDEVLKLVETAHTEAWTIINDNRDILDELVRQLLVKETLNEKELAEIFAPIKKAPVRPVWLSNDRRPDSDKPPVEIPESLKRSVGMKPEE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias670-697Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS990240
EMBL· GenBank· DDBJ
EEQ55321.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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