C4YUZ3 · C4YUZ3_9RICK

Function

function

Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site17-22GTP (UniProtKB | ChEBI)
Binding site134-137GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionguanosine tetraphosphate binding
Molecular Functionribosome binding
Molecular Functiontranslation elongation factor activity
Biological Processpositive regulation of translation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongation factor 4
  • EC number
  • Short names
    EF-4
  • Alternative names
    • Ribosomal back-translocase LepA

Gene names

    • Name
      lepA
    • ORF names
      REIS_1266

Organism names

  • Taxonomic identifier
  • Strain
    • endosymbiont of Ixodes scapularis
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rickettsiales > Rickettsiaceae > Rickettsieae > Rickettsia > spotted fever group

Accessions

  • Primary accession
    C4YUZ3

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-187Tr-type G

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    600
  • Mass (Da)
    67,335
  • Last updated
    2009-07-28 v1
  • Checksum
    39132140310B6569
MDNQKYIRNFSIIAHIDHGKSTLADRLIEHCGGLQIREMSQQVLDSMDIEKERGITIKAQTVRLVYKAKDGNTYYLNLMDTPGHVDFAYEVSRSLAACEGSLLVVDSTQGVEAQTLANVYQAIENDHEIVPVLNKIDLPASEPEQVKQQIEDIIGIDASEAVLISAKSGIGIDLVLEVIVNKLPPPKESNSDILKALLVDSWYAPYLGVVILVRVIDGYLRKNMRIKMMATNSVYTVENVGYFTPKKHISDVLHAGEIGFFTASIKQIADCKVGDTITDEKKPCEQALPGFKPNLPVVFCGLYPTDSSEFEHLKYSLAKLRLNDASFEYEMESSSALGVGFRCGFLGLLHLEIIQERLSREFDLDLITTAPSVVYKIHMRDGESLEIHNPADLPDLQKIELIEEPWIKATIMVPDEFLGAVLLLCTEKRGMQLDHSYIANRAKIVYKLPLNEIVYDFYDRLKSCSKGYASFEWQMDVYEPSELVKLGILVNAEVVDALSTIVHRSRAEQRGRALCVRLKDLIPRQQIDIAIQASIGSRIIARETIKALRKDVLSKCYGGDISRKRKLLEKQKAGKKRMRQYGNIEIPQSAFIAALKIGDE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM000770
EMBL· GenBank· DDBJ
EER22063.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp