C4YUM6 · C4YUM6_9RICK
- ProteinATP-dependent DNA helicase
- GenepcrA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids653 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | DNA helicase complex | |
Molecular Function | 3'-5' DNA helicase activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | DNA binding | |
Molecular Function | isomerase activity | |
Biological Process | DNA unwinding involved in DNA replication | |
Biological Process | recombinational repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent DNA helicase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rickettsiales > Rickettsiaceae > Rickettsieae > Rickettsia > spotted fever group
Accessions
- Primary accessionC4YUM6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 8-288 | UvrD-like helicase ATP-binding | ||||
Sequence: HTLNPEQQKAVLHTEGPLLLLAGAGTGKTKVLTSRIANIIHQNLASPQNILAVTFTNKAAKEMAERVNSLINCYGLNIGTFHSMAARILRDQIEHLNLGLNNRFTIISHDDQLKLVKDIVKLKDIDTKKYAPKLIHIIISRWKDQGLLPSKLSASDTNLPLQRVAKLVYEEYQKNLLISNVLDFGDLLLYNNELFIKNPKILRYYQEKYRYILIDEYQDTNVVQYLWARMLASLYKNICCVGDDDQSIYGWRGAEVGNILRFEKDFAGATIIKLEQNYRST | ||||||
Domain | 289-559 | UvrD-like helicase C-terminal | ||||
Sequence: LPILAAASNVINNNKNRHGKTLWTDRESGEKIKIISCWSDKEEARYIAGEIDKLVREDRYNAGNIAILVRAGFQTRSFEEAFINSAIPYKIIGGLRFYERMEIRDVLAYIRISLNQNDNLALERIINVPKRAIGAASLNKIRVYALERNISNFAAIKEMLEIGEIKAKSYDSLKDLVTKIDNWYERFSIDAPINVVKAILDDSSYLEMLQEEKTEEALGRIENINEMLRAIAEFNDIHDFIEHSSLVMENEVLETNYGGSVTIMTLHAAKG |
Sequence similarities
Belongs to the helicase family. UvrD subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length653
- Mass (Da)74,998
- Last updated2009-07-28 v1
- Checksum770B86502F4082CC