C4YUM6 · C4YUM6_9RICK

Function

function

Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.

Catalytic activity

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site29-36ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular ComponentDNA helicase complex
Molecular Function3'-5' DNA helicase activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA binding
Molecular Functionisomerase activity
Biological ProcessDNA unwinding involved in DNA replication
Biological Processrecombinational repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent DNA helicase
  • EC number

Gene names

    • Name
      pcrA
    • ORF names
      REIS_1135

Organism names

  • Taxonomic identifier
  • Strain
    • endosymbiont of Ixodes scapularis
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rickettsiales > Rickettsiaceae > Rickettsieae > Rickettsia > spotted fever group

Accessions

  • Primary accession
    C4YUM6

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-288UvrD-like helicase ATP-binding
Domain289-559UvrD-like helicase C-terminal

Sequence similarities

Belongs to the helicase family. UvrD subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    653
  • Mass (Da)
    74,998
  • Last updated
    2009-07-28 v1
  • Checksum
    770B86502F4082CC
MQNQDFIHTLNPEQQKAVLHTEGPLLLLAGAGTGKTKVLTSRIANIIHQNLASPQNILAVTFTNKAAKEMAERVNSLINCYGLNIGTFHSMAARILRDQIEHLNLGLNNRFTIISHDDQLKLVKDIVKLKDIDTKKYAPKLIHIIISRWKDQGLLPSKLSASDTNLPLQRVAKLVYEEYQKNLLISNVLDFGDLLLYNNELFIKNPKILRYYQEKYRYILIDEYQDTNVVQYLWARMLASLYKNICCVGDDDQSIYGWRGAEVGNILRFEKDFAGATIIKLEQNYRSTLPILAAASNVINNNKNRHGKTLWTDRESGEKIKIISCWSDKEEARYIAGEIDKLVREDRYNAGNIAILVRAGFQTRSFEEAFINSAIPYKIIGGLRFYERMEIRDVLAYIRISLNQNDNLALERIINVPKRAIGAASLNKIRVYALERNISNFAAIKEMLEIGEIKAKSYDSLKDLVTKIDNWYERFSIDAPINVVKAILDDSSYLEMLQEEKTEEALGRIENINEMLRAIAEFNDIHDFIEHSSLVMENEVLETNYGGSVTIMTLHAAKGLEFDVVFLPGWEEGVFPSQRSLDEDGEKGLEEERRIAYVGITRAKKDLYITHAENRKIFYEIVRSYPSRFITEIPDEITIRTSSMKKYTSFYKF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM000770
EMBL· GenBank· DDBJ
EER21946.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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