C4XPA8 · LEU1_SOLM1

Function

function

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site16Mn2+ (UniProtKB | ChEBI)
Binding site204Mn2+ (UniProtKB | ChEBI)
Binding site206Mn2+ (UniProtKB | ChEBI)
Binding site240Mn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function2-isopropylmalate synthase activity
Molecular Functionacetyl-CoA C-acetyltransferase activity
Molecular Functionmanganese ion binding
Biological ProcessL-leucine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-isopropylmalate synthase
  • EC number
  • Alternative names
    • Alpha-IPM synthase
    • Alpha-isopropylmalate synthase

Gene names

    • Name
      leuA
    • Ordered locus names
      DMR_15980

Organism names

Accessions

  • Primary accession
    C4XPA8

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004068941-5132-isopropylmalate synthase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain7-269Pyruvate carboxyltransferase
Region393-513Regulatory domain

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    513
  • Mass (Da)
    55,331
  • Last updated
    2009-07-28 v1
  • Checksum
    A56B2E28026BA3F0
MSDDNRVYIFDTTLRDGEQSPGATMTREEKVRMARQLETLGVDIIEAGFPAASEGDFQAVSAIAAAVKTPVVAALCRALASDIDRGFEAIKGAQRRRIHTFLATSELHMQHKLNKTPTQVLDMIEAAVSHAASKGVEVQFSAEDASRSEPAFLVAACERAINAGATILNIPDTVGYAQPAEFAELIRHLMTTVRGAGGVTFAVHCHNDLGLAVANTLAALHAGARQAEVTLSGIGERAGNASLEQVVMGLNTRPNYYNLTTGIVTEELFPSCRRLSGIIGQPIPPYAPIMGRNAFAHESGIHQHGVLKDRRTYEIMTAESIGRKGAVVVLGKHSGRHALDAKVKELGYALNDEELLVVFVAVKQLADRKQRILDEDIEALILEKVLRRPDRYALQFLSVHCGNVELAPFAVVEMQVEGQTVRHYSAGSGPVDAVFNAVCQAVGRKPDLEEYQINAITGGTDAQGEVTVRIKDGTATTVGRGVHDDVIMASTLAFINALNRLAKKEEERTCPQL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP010904
EMBL· GenBank· DDBJ
BAH75089.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp