C4XIR5 · THI4_SOLM1

Function

function

Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site36NAD+ (UniProtKB | ChEBI); ligand shared between two adjacent protomers; in other chain
Binding site55-56NAD+ (UniProtKB | ChEBI); ligand shared between two adjacent protomers; in other chain
Binding site63NAD+ (UniProtKB | ChEBI); ligand shared between two adjacent protomers; in other chain
Binding site127NAD+ (UniProtKB | ChEBI); ligand shared between two adjacent protomers; in other chain
Binding site157-159NAD+ (UniProtKB | ChEBI); ligand shared between two adjacent protomers
Binding site159Fe cation (UniProtKB | ChEBI); ligand shared between two adjacent protomers
Binding site174Fe cation (UniProtKB | ChEBI); ligand shared between two adjacent protomers; in other chain
Binding site228NAD+ (UniProtKB | ChEBI); ligand shared between two adjacent protomers; in other chain
Binding site238glycine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioniron ion binding
Molecular Functionpentosyltransferase activity
Biological Processthiamine biosynthetic process
Biological Processthiamine diphosphate biosynthetic process
Biological Processthiazole biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thiamine thiazole synthase
  • EC number

Gene names

    • Name
      thi4
    • Ordered locus names
      DMR_31420

Organism names

Accessions

  • Primary accession
    C4XIR5

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10002050041-263Thiamine thiazole synthase

Interaction

Subunit

Homooctamer; tetramer of dimers.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the THI4 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    263
  • Mass (Da)
    27,873
  • Last updated
    2009-07-28 v1
  • Checksum
    ADA793304C972638
MSLDERIITQAILETYFEKFKSSLDLDVAIVGGGPSGMTAARLLAADGFNVALFERKLSLGGGMWGGGMTFNMIVVQEESVHLLTDVGVPVKRYKDNYFTADAVAATTTLASAACLAGAKIFNCMSVEDVMLREENGVKRVTGIVINSSPVEIAGLHVDPVVLGSKYLVEATGHAVEVLQTLVRKNDVRLNTPSGGIEGEQSMWADTAEINTVKNTREIFPGLYVAGMAANASYGSYRMGPIFGGMLLSGEKVAADIAAKLKG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP010904
EMBL· GenBank· DDBJ
BAH76633.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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