C4WS35 · C4WS35_ACYPI

Function

function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site10-15ITP (UniProtKB | ChEBI)
Binding site44Mg2+ (UniProtKB | ChEBI)
Binding site56ITP (UniProtKB | ChEBI)
Binding site72Mg2+ (UniProtKB | ChEBI)
Binding site72-73ITP (UniProtKB | ChEBI)
Binding site147-150ITP (UniProtKB | ChEBI)
Binding site170ITP (UniProtKB | ChEBI)
Binding site175-176ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmetal ion binding
Molecular Functionnucleoside triphosphate diphosphatase activity
Molecular Functionnucleotide binding
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      ACYPI009106
    • Synonyms
      100168402

Organism names

  • Taxonomic identifier
  • Strain
    • LSR1
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Hemiptera > Sternorrhyncha > Aphidomorpha > Aphidoidea > Aphididae > Macrosiphini > Acyrthosiphon

Accessions

  • Primary accession
    C4WS35

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    193
  • Mass (Da)
    21,923
  • Last updated
    2009-07-28 v1
  • Checksum
    94E4596B5C81D1DC
MSKKNIVFVTGNVKKLEEVMQMFKNFYKDSVPFDLSNKNIDLPEHQGERDEICKMKAQAAFEIIKGPCIVEDTSLCFNAMGGLPGPYIKWFLKATGPIGLYRMLKGFEDKTAMAVCTVAYVNEQGEVNIFSGETNGTIIEPTAIETFGWDSCFRPDGYEITYAEMPKEEKNLISHRMKAMYKLKEFLDQNVIV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK340030
EMBL· GenBank· DDBJ
BAH70705.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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