C4PKA1 · C4PKA1_HUMAN

Function

function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Cofactor

Protein has several cofactor binding sites:
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme groups non-covalently.
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme groups non-covalently.

Features

Showing features for binding site.

138050100150200250300350
TypeIDPosition(s)Description
Binding site83Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site97Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site182Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site196Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site201a ubiquinone (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processrespiratory electron transport chain

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b

Gene names

    • Name
      CYTB
    • Synonyms
      cytb

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • LHON-001-III7
    • DR55
    • Td29
    • J81
    • R628
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    C4PKA1

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-56Helical
Transmembrane77-98Helical
Transmembrane113-133Helical
Transmembrane140-158Helical
Transmembrane178-200Helical
Transmembrane229-246Helical
Transmembrane288-308Helical
Transmembrane320-339Helical
Transmembrane345-372Helical

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-209Cytochrome b/b6 N-terminal region profile
Domain210-380Cytochrome b/b6 C-terminal region profile

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    380
  • Mass (Da)
    42,730
  • Last updated
    2009-07-07 v1
  • Checksum
    90097B07FF2C1FD8
MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFFTFHFILPFIIAALATLHLLFLHETGSNNPLGITSHSDKITFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJ467942
EMBL· GenBank· DDBJ
ACK55234.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383620
EMBL· GenBank· DDBJ
ACM75198.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ969382
EMBL· GenBank· DDBJ
ACQ73891.1
EMBL· GenBank· DDBJ
Genomic DNA
GU296590
EMBL· GenBank· DDBJ
ADB05608.1
EMBL· GenBank· DDBJ
Genomic DNA
GU455417
EMBL· GenBank· DDBJ
ADD20805.1
EMBL· GenBank· DDBJ
Genomic DNA
HM346885
EMBL· GenBank· DDBJ
ADI79652.1
EMBL· GenBank· DDBJ
Genomic DNA
JF824889
EMBL· GenBank· DDBJ
AEG63117.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ044933
EMBL· GenBank· DDBJ
AEV48708.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ703849
EMBL· GenBank· DDBJ
AFF88007.1
EMBL· GenBank· DDBJ
Genomic DNA
KC505069
EMBL· GenBank· DDBJ
AGI49577.1
EMBL· GenBank· DDBJ
Genomic DNA
KC985167
EMBL· GenBank· DDBJ
AGO50912.1
EMBL· GenBank· DDBJ
Genomic DNA
KC911621
EMBL· GenBank· DDBJ
AGO94825.1
EMBL· GenBank· DDBJ
Genomic DNA
KF540644
EMBL· GenBank· DDBJ
AGZ07676.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451297
EMBL· GenBank· DDBJ
AGZ70506.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ154774
EMBL· GenBank· DDBJ
AHW37733.1
EMBL· GenBank· DDBJ
Genomic DNA
KM245131
EMBL· GenBank· DDBJ
AIY55879.1
EMBL· GenBank· DDBJ
Genomic DNA
KU131375
EMBL· GenBank· DDBJ
AMB50776.1
EMBL· GenBank· DDBJ
Genomic DNA
KX456458
EMBL· GenBank· DDBJ
APD52996.1
EMBL· GenBank· DDBJ
Genomic DNA
KY496888
EMBL· GenBank· DDBJ
AQX91601.1
EMBL· GenBank· DDBJ
Genomic DNA
MF362816
EMBL· GenBank· DDBJ
ASF85314.1
EMBL· GenBank· DDBJ
Genomic DNA
KY645522
EMBL· GenBank· DDBJ
ASR12575.1
EMBL· GenBank· DDBJ
Genomic DNA
KY681006
EMBL· GenBank· DDBJ
ASZ83179.1
EMBL· GenBank· DDBJ
Genomic DNA
MF177182
EMBL· GenBank· DDBJ
AUR39844.1
EMBL· GenBank· DDBJ
Genomic DNA
MF695873
EMBL· GenBank· DDBJ
AUT77470.1
EMBL· GenBank· DDBJ
Genomic DNA
MG272849
EMBL· GenBank· DDBJ
AVL88469.1
EMBL· GenBank· DDBJ
Genomic DNA
MH499931
EMBL· GenBank· DDBJ
AXT16631.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449093
EMBL· GenBank· DDBJ
AYW05933.1
EMBL· GenBank· DDBJ
Genomic DNA
MN503459
EMBL· GenBank· DDBJ
QEW89154.1
EMBL· GenBank· DDBJ
Genomic DNA
MN610423
EMBL· GenBank· DDBJ
QLA48638.1
EMBL· GenBank· DDBJ
Genomic DNA
MN687201
EMBL· GenBank· DDBJ
QLH91453.1
EMBL· GenBank· DDBJ
Genomic DNA
MT419274
EMBL· GenBank· DDBJ
QMP95095.1
EMBL· GenBank· DDBJ
Genomic DNA
MK795841
EMBL· GenBank· DDBJ
QQP22756.1
EMBL· GenBank· DDBJ
Genomic DNA
MN857267
EMBL· GenBank· DDBJ
QTK14038.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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