C4PKA1 · C4PKA1_HUMAN
- ProteinCytochrome b
- GeneCYTB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids380 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 heme groups non-covalently.
Note: Binds 2 heme groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 83 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 97 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 182 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 196 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 201 | a ubiquinone (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | respiratory electron transport chain |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionC4PKA1
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 30-56 | Helical | ||||
Sequence: WWNFGSLLGACLILQITTGLFLAMHYS | ||||||
Transmembrane | 77-98 | Helical | ||||
Sequence: WIIRYLHANGASMFFICLFLHI | ||||||
Transmembrane | 113-133 | Helical | ||||
Sequence: WNIGIILLLATMATAFMGYVL | ||||||
Transmembrane | 140-158 | Helical | ||||
Sequence: FWGATVITNLLSAIPYIGT | ||||||
Transmembrane | 178-200 | Helical | ||||
Sequence: FFTFHFILPFIIAALATLHLLFL | ||||||
Transmembrane | 229-246 | Helical | ||||
Sequence: ALGLLLFLLSLMTLTLFS | ||||||
Transmembrane | 288-308 | Helical | ||||
Sequence: LGGVLALLLSILILAMIPILH | ||||||
Transmembrane | 320-339 | Helical | ||||
Sequence: LSQSLYWLLAADLLILTWIG | ||||||
Transmembrane | 345-372 | Helical | ||||
Sequence: YPFTIIGQVASVLYFTTILILMPTISLI |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Interaction
Subunit
The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-209 | Cytochrome b/b6 N-terminal region profile | ||||
Sequence: MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFFTFHFILPFIIAALATLHLLFLHETGSNNPL | ||||||
Domain | 210-380 | Cytochrome b/b6 C-terminal region profile | ||||
Sequence: GITSHSDKITFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA |
Sequence similarities
Belongs to the cytochrome b family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length380
- Mass (Da)42,730
- Last updated2009-07-07 v1
- Checksum90097B07FF2C1FD8
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FJ467942 EMBL· GenBank· DDBJ | ACK55234.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383620 EMBL· GenBank· DDBJ | ACM75198.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ969382 EMBL· GenBank· DDBJ | ACQ73891.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU296590 EMBL· GenBank· DDBJ | ADB05608.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU455417 EMBL· GenBank· DDBJ | ADD20805.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM346885 EMBL· GenBank· DDBJ | ADI79652.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF824889 EMBL· GenBank· DDBJ | AEG63117.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ044933 EMBL· GenBank· DDBJ | AEV48708.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ703849 EMBL· GenBank· DDBJ | AFF88007.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC505069 EMBL· GenBank· DDBJ | AGI49577.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC985167 EMBL· GenBank· DDBJ | AGO50912.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC911621 EMBL· GenBank· DDBJ | AGO94825.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF540644 EMBL· GenBank· DDBJ | AGZ07676.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451297 EMBL· GenBank· DDBJ | AGZ70506.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ154774 EMBL· GenBank· DDBJ | AHW37733.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM245131 EMBL· GenBank· DDBJ | AIY55879.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU131375 EMBL· GenBank· DDBJ | AMB50776.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX456458 EMBL· GenBank· DDBJ | APD52996.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY496888 EMBL· GenBank· DDBJ | AQX91601.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF362816 EMBL· GenBank· DDBJ | ASF85314.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645522 EMBL· GenBank· DDBJ | ASR12575.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY681006 EMBL· GenBank· DDBJ | ASZ83179.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF177182 EMBL· GenBank· DDBJ | AUR39844.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF695873 EMBL· GenBank· DDBJ | AUT77470.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG272849 EMBL· GenBank· DDBJ | AVL88469.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH499931 EMBL· GenBank· DDBJ | AXT16631.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449093 EMBL· GenBank· DDBJ | AYW05933.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN503459 EMBL· GenBank· DDBJ | QEW89154.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN610423 EMBL· GenBank· DDBJ | QLA48638.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN687201 EMBL· GenBank· DDBJ | QLH91453.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT419274 EMBL· GenBank· DDBJ | QMP95095.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK795841 EMBL· GenBank· DDBJ | QQP22756.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN857267 EMBL· GenBank· DDBJ | QTK14038.1 EMBL· GenBank· DDBJ | Genomic DNA |