C4PK56 · C4PK56_9MONO

  • Protein
    Polymerase cofactor VP35
  • Gene
    VP35
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell cytoplasm
Cellular Componentvirion component
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity
Biological Processsymbiont-mediated suppression of host toll-like receptor signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Polymerase cofactor VP35

Gene names

    • Name
      VP35
    • ORF names
      SEBOVgp2

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Boniface
    • SUDV/H.sapiens-tc/SSD/1979/Maleo
    • Sudan virus/C.porcellus-lab/SSD/1976/Nzara-Boneface
    • Ebola virus/H.sapiens-tc/Sudan/1976/Boniface-R4142L
    • Ebola virus/H.sapiens-wt/SSD/1976/Maridi-BNI/DT
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Filoviridae > Orthoebolavirus > Orthoebolavirus sudanense

Accessions

  • Primary accession
    C4PK56

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for cross-link.

TypeIDPosition(s)Description
Cross-link298Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Keywords

Interaction

Subunit

Homooligomer.

Structure

Family & Domains

Features

Showing features for coiled coil, domain.

Type
IDPosition(s)Description
Coiled coil86-113
Domain204-329VP35 IID

Sequence similarities

Belongs to the filoviridae polymerase cofactor VP35 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    329
  • Mass (Da)
    36,210
  • Last updated
    2009-07-07 v1
  • Checksum
    008DBE60306EBC3D
MQQDKTYRHHGPEVSGWFSEQLMTGKIPLTEVFVDVETKPSPTPITIISKNPKTTRKSDKQVQTDDASSLLTEEVKTAINSVISAVRRQTNAIESLESRIANLEASLKPVQDMAKTISSLNRSCAEMVAKYDLLVMTTGRATATAAATEAYWNEHGQAPPGPSLYEDDAIKAKLKDPNGKVPESVKQAYTNLDSTSALNEENFGRPYISAKDLKEIIYDHLPGFGTAFHQLVQVICKIGKDNNILDIIHAEFQASLAEGDSPQCALIQITKRIPTFQDASPPIVHIKSRGDIPKACQKSLRPVPPSPKIDRGWVCIFQFQDGKTLGLKI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJ968794
EMBL· GenBank· DDBJ
ACR33188.1
EMBL· GenBank· DDBJ
Viral cRNA
KC242783
EMBL· GenBank· DDBJ
AGB56676.1
EMBL· GenBank· DDBJ
Viral cRNA
KT878488
EMBL· GenBank· DDBJ
ALL26373.1
EMBL· GenBank· DDBJ
Viral cRNA
MH121162
EMBL· GenBank· DDBJ
AWK96578.1
EMBL· GenBank· DDBJ
Viral cRNA
MK952150
EMBL· GenBank· DDBJ
QDC12556.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

Disclaimer

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