C4A0B6 · C4A0B6_BRAFL

Function

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site.

113361002003004005006007008009001,0001,1001,2001,300
Type
IDPosition(s)Description
Binding site977ATP (UniProtKB | ChEBI)
Binding site1001ATP (UniProtKB | ChEBI)
Binding site1048-1054ATP (UniProtKB | ChEBI)
Active site1121Proton donor/acceptor
Binding site1125-1126ATP (UniProtKB | ChEBI)
Binding site1139ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentaxon
Cellular Componentinsulin receptor complex
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functioninsulin receptor activity
Molecular Functioninsulin receptor substrate binding
Molecular Functionphosphatidylinositol 3-kinase binding
Biological Processglucose homeostasis
Biological Processpositive regulation of MAPK cascade
Biological Processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processprotein autophosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein kinase receptor
  • EC number

Gene names

    • ORF names
      BRAFLDRAFT_128184

Organism names

Accessions

  • Primary accession
    C4A0B6

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane902-925Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-29
ChainPRO_500293517130-1336Tyrosine-protein kinase receptor

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain440-553Fibronectin type-III
Domain557-647Fibronectin type-III
Region704-723Disordered
Domain781-885Fibronectin type-III
Domain967-1256Protein kinase
Region1064-1093Disordered
Compositional bias1074-1088Polar residues
Region1289-1336Disordered
Compositional bias1292-1336Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,336
  • Mass (Da)
    151,287
  • Last updated
    2009-07-28 v1
  • Checksum
    763A2E02244BDA7B
MRVVDKMAGLMWAALTLVIGLGLLVPSNGEEYICDSMDIRNRVTNLRQLENCTVIEGYLQILLIDFAEEQDYRGLSFPNLVEITDYFLLYRVRGLTNLSELFPNLAVIRGTNLFFNYALVVFEMLDMQKIGLYSLQNITRGSVRIEKNPNLCYLDTIDWSFIAESGYRNNFIVDNRDEEECGYCPKRCRNENPVVLQDLCWAEEHCQKVCPESCLGNCLDGSSGCCHENCIGGCDGPTERDCVACKYFVHNGECLIQCPPDTYQYKDRRCITEDECPNTTNAVWKLHHRKCIPECPSGYTTDVNNPRLCTECEGQCPKYNIITELEENLGLIEEVGHYVAIVRSYALVTLDFLRSLKRIRGIQKENGYAFYVLDNRNLEKLFEWDRTDLTIDEGKLFFHFNPKLCRHVILTMVEKVGLPPDTITDTDISTLTNGDQAQCSFSRLEIEEINTRKDMIILRWSEFTPPDPRDLLSYTVSYRETEEQGIDEYDGQDACGNTEWKEFDVSPDQRAHIITGLKPWTQYALLVKTYTKAGAREGSGAKSDIVYARTDADKPTHPQDVVVYSNSSNTLIITWKPPNRPNGNVTHYIVRYKRQLEEEDSMEHREYCIGGLKPHRPTQGLEDIVNNEEEPNNGTIGDGTCCECPKSEDEIRIEEEEAAFQQEFENFLHNNVYHKRENETRAGRRRRELPVTARPFYSNQTVNVTLPSTNTTAPPTPTPNPNPQLETTVWNEHMVVLTGLRHFSEYIIEVIACNADVINVGCSGSAVELARTQADDSADNIPGNITVDVGVDVETKVKMAKLYWPKPYQPNSMVVLYNVEYKKLGADGNYEQPQQKCVESYKLMEQQGYTISNLVAGNYSVRVQATSFAGNGSWSNYVTFYVEEEDTSPANQDPQQQVPVSLMIGMGVGFSLLVLLAVVFAFWYCTKKRFGDKQMPNGVLYASVNPEYMSSADVYVPDEWEVPREKITLIRELGQGSFGMVYEGEAKDLVKDEPMVSVAVKTVNESASIRERIEFLNEASVMKTFNCHHVVKLMGVVSKGQPTLVVMELMALGDLKNYLRRHRPEEDAGLSDSPASNEAKNSPFAENDNDPPPTFKDIIQMAGEIADGMSYLAAKKFVHRDLACRNCMVAQDRTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTSQSDVWSYGVVLWEMATLASQPYQGKSNEEVLKFVIDGGMLEKPEGCPNKLYDLMKLCWQYRQSMRPTFLEIVEILSPELQAHFAEVSFYHSLDNHGREPLEMDDVALDSGADTETEMYPSGSEFSSTPSPPSETPYSHMNGSHPQNGSMNLRIPKSTLC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1074-1088Polar residues
Compositional bias1292-1336Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GG666796
EMBL· GenBank· DDBJ
EEN41775.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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