C4A0B6 · C4A0B6_BRAFL
- ProteinTyrosine-protein kinase receptor
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1336 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 977 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1001 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1048-1054 | ATP (UniProtKB | ChEBI) | |||
Active site | 1121 | Proton donor/acceptor | |||
Binding site | 1125-1126 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1139 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | insulin receptor complex | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | insulin receptor activity | |
Molecular Function | insulin receptor substrate binding | |
Molecular Function | phosphatidylinositol 3-kinase binding | |
Biological Process | glucose homeostasis | |
Biological Process | positive regulation of MAPK cascade | |
Biological Process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | |
Biological Process | protein autophosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein kinase receptor
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Cephalochordata > Leptocardii > Amphioxiformes > Branchiostomatidae > Branchiostoma
Accessions
- Primary accessionC4A0B6
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 902-925 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-29 | ||||
Chain | PRO_5002935171 | 30-1336 | Tyrosine-protein kinase receptor | ||
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 440-553 | Fibronectin type-III | |||
Domain | 557-647 | Fibronectin type-III | |||
Region | 704-723 | Disordered | |||
Domain | 781-885 | Fibronectin type-III | |||
Domain | 967-1256 | Protein kinase | |||
Region | 1064-1093 | Disordered | |||
Compositional bias | 1074-1088 | Polar residues | |||
Region | 1289-1336 | Disordered | |||
Compositional bias | 1292-1336 | Polar residues | |||
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,336
- Mass (Da)151,287
- Last updated2009-07-28 v1
- Checksum763A2E02244BDA7B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1074-1088 | Polar residues | |||
Compositional bias | 1292-1336 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GG666796 EMBL· GenBank· DDBJ | EEN41775.1 EMBL· GenBank· DDBJ | Genomic DNA |