Essential maintenance is planned to begin on Tue Jan 28 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ during this time.

C3ZX35 · C3ZX35_BRAFL

Function

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 3 Ca2+ ions per subunit. Two of the Ca2+ ions are bound to the C2 domain.

Features

Showing features for active site, binding site.

147850100150200250300350400450
Type
IDPosition(s)Description
Active site47
Binding site48Ca2+ 3 (UniProtKB | ChEBI); catalytic
Binding site77Ca2+ 3 (UniProtKB | ChEBI); catalytic
Binding site79Ca2+ 3 (UniProtKB | ChEBI); catalytic
Active site92
Binding site126Ca2+ 3 (UniProtKB | ChEBI); catalytic
Binding site174substrate
Binding site176substrate
Binding site245substrate
Binding site376Ca2+ 4 (UniProtKB | ChEBI)
Binding site400Ca2+ 4 (UniProtKB | ChEBI)
Binding site431Ca2+ 5 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmetal ion binding
Molecular Functionphosphatidylinositol phospholipase C activity
Biological Processlipid catabolic process
Biological Processphosphatidylinositol metabolic process
Biological Processphosphatidylinositol-mediated signaling
Biological Processrelease of sequestered calcium ion into cytosol

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoinositide phospholipase C
  • EC number

Gene names

    • ORF names
      BRAFLDRAFT_241494

Organism names

Accessions

  • Primary accession
    C3ZX35

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain216-332PI-PLC Y-box
Domain332-460C2

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    478
  • Mass (Da)
    53,776
  • Last updated
    2009-07-28 v1
  • MD5 Checksum
    4850A8546B261CEC3BB808FD7DFE1CF5
KNDTSLPSTGFTLYLQSAEGDVFNHTHDEVYQDMTQPLSHYFIASSHNTYLLEDQIRGPSSKEGYVRVLLKGCRFLELDCWDGDDGEPVIYHGYTLTSKVLFRDVIEAIGRYAFKASPYPVFLSLENHCSVVQQRLLATHMVNILGDSLCNIPSTPDMQELPSPQRLRGKIIVKNKKLKRNVVEDDVSDEDEAAETEDVEVQERVKTSKEKLAKELSDLVNICEAVHFHSFQHSRENDMPYNMSSIKEGKANHLVEEQAADFIDHTKRQLVKIYPSGGRVDSSNIDPYLYWSVGCQIVALNYQTPCDQMDLNLGLFRQNGRCGYVLKPEALRDGQTRLDTSKNILGKYKKTLKIKVISGFQLPTPEGEGSGGSAVDPYVKVQVYGVPADCAEDGTEVVKNNGFHPVWNCDMSFPLTFPDLALVRFEVKEHDTMSDSETIGQFSLPVSSMQQGYRHVHLLSKDQEDLSPAALFIHVSLQ

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GG666707
EMBL· GenBank· DDBJ
EEN42913.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help