C3ZX35 · C3ZX35_BRAFL
- ProteinPhosphoinositide phospholipase C
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids478 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+
Cofactor
Note: Binds 3 Ca2+ ions per subunit. Two of the Ca2+ ions are bound to the C2 domain.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 47 | ||||
Binding site | 48 | Ca2+ 3 (UniProtKB | ChEBI); catalytic | |||
Binding site | 77 | Ca2+ 3 (UniProtKB | ChEBI); catalytic | |||
Binding site | 79 | Ca2+ 3 (UniProtKB | ChEBI); catalytic | |||
Active site | 92 | ||||
Binding site | 126 | Ca2+ 3 (UniProtKB | ChEBI); catalytic | |||
Binding site | 174 | substrate | |||
Binding site | 176 | substrate | |||
Binding site | 245 | substrate | |||
Binding site | 376 | Ca2+ 4 (UniProtKB | ChEBI) | |||
Binding site | 400 | Ca2+ 4 (UniProtKB | ChEBI) | |||
Binding site | 431 | Ca2+ 5 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | metal ion binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | lipid catabolic process | |
Biological Process | phosphatidylinositol metabolic process | |
Biological Process | phosphatidylinositol-mediated signaling | |
Biological Process | release of sequestered calcium ion into cytosol |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoinositide phospholipase C
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Cephalochordata > Leptocardii > Amphioxiformes > Branchiostomatidae > Branchiostoma
Accessions
- Primary accessionC3ZX35
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusFragment
- Length478
- Mass (Da)53,776
- Last updated2009-07-28 v1
- MD5 Checksum4850A8546B261CEC3BB808FD7DFE1CF5
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GG666707 EMBL· GenBank· DDBJ | EEN42913.1 EMBL· GenBank· DDBJ | Genomic DNA |