C3ZSH0 · C3ZSH0_BRAFL
- ProteinPeroxisomal bifunctional enzyme
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids719 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- (2E)-hexadecenedioyl-CoA + H2O = (3S)-hydroxyhexadecanedioyl-CoAThis reaction proceeds in the forward direction.
- (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA = (2E)-2-methylbut-2-enoyl-CoA + H2OThis reaction proceeds in the backward direction.
- (3E)-decenoyl-CoA = (2E)-decenoyl-CoAThis reaction proceeds in the forward direction.
- (3E)-hexenoyl-CoA = (2E)-hexenoyl-CoAThis reaction proceeds in the forward direction.
- (3E,5Z)-octadienoyl-CoA = (2E,5Z)-octadienoyl-CoAThis reaction proceeds in the backward direction.
- (3E,5Z)-tetradecadienoyl-CoA = (2E,5Z)-tetradecadienoyl-CoAThis reaction proceeds in the backward direction.
- (3S)-hydroxydecanoyl-CoA + NAD+ = 3-oxodecanoyl-CoA + H+ + NADHThis reaction proceeds in the forward direction.
- (3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2OThis reaction proceeds in the backward direction.
- (3S)-hydroxyhexadecanedioyl-CoA + NAD+ = 3-oxohexadecanedioyl-CoA + H+ + NADHThis reaction proceeds in the forward direction.
- (3S)-hydroxyhexadecanoyl-CoA + NAD+ = 3-oxohexadecanoyl-CoA + H+ + NADHThis reaction proceeds in the forward direction.
- (3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2OThis reaction proceeds in the backward direction.
- (3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2OThis reaction proceeds in the backward direction.
- (3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoAThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism; fatty acid beta-oxidation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | peroxisome | |
Molecular Function | 3-hydroxyacyl-CoA dehydrogenase activity | |
Molecular Function | enoyl-CoA hydratase activity | |
Molecular Function | NAD+ binding | |
Biological Process | fatty acid beta-oxidation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeroxisomal bifunctional enzyme
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Cephalochordata > Leptocardii > Amphioxiformes > Branchiostomatidae > Branchiostoma
Accessions
- Primary accessionC3ZSH0
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 301-476 | 3-hydroxyacyl-CoA dehydrogenase NAD binding | ||||
Sequence: VGVLGAGTMGIGISISLLQAGLKVVLTEVNKAQLDKGKSYCKFWLKKSNSNTELSGGKPQPMQLRATTDYSQLREVDLVIEAVFEDLALKKKVFRQLDAVTNPRTILATNTSGLDIDKIAAATQRPDKVIGTHFFSPAQVMRLLENIYGRHTSGETIATAMQLGATIGKVGVLVGN | ||||||
Domain | 479-584 | 3-hydroxyacyl-CoA dehydrogenase C-terminal | ||||
Sequence: GFVGNRMKGLNFTEAMFLLEEGADPQDVDKALEEFGFAMGPFRVSDLAGGDVHWRRRIQAGLTTEHGPPPYTPVLYRQGNRYSPLADMLCMQGRFGQKTGAGWYRY | ||||||
Domain | 620-707 | 3-hydroxyacyl-CoA dehydrogenase C-terminal | ||||
Sequence: IVERCLFPLINEGFRILEEGLAAGPQDIDVIFLLGFGWPRHTGGPMYYADKVVGLGNLLQSLEKYRAHHPRSAHWVPSSLLRKMAAQG |
Sequence similarities
Belongs to the enoyl-CoA hydratase/isomerase family.
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length719
- Mass (Da)78,549
- Last updated2009-07-28 v1
- Checksum0391A2E426FA2109