C3YDS7 · NNRE_BRAFL
- ProteinNAD(P)H-hydrate epimerase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids273 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
Catalytic activity
- (6R)-NADHX = (6S)-NADHX
Cofactor
Note: Binds 1 potassium ion per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 105-109 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: NNGGD | ||||||
Binding site | 106 | K+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 170 | K+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 174-180 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: GFSFKGE | ||||||
Binding site | 203 | (6S)-NADPHX (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 206 | K+ (UniProtKB | ChEBI) | ||||
Sequence: S |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | metal ion binding | |
Molecular Function | NADHX epimerase activity | |
Molecular Function | NADPHX epimerase activity | |
Molecular Function | nucleotide binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD(P)H-hydrate epimerase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Cephalochordata > Leptocardii > Amphioxiformes > Branchiostomatidae > Branchiostoma
Accessions
- Primary accessionC3YDS7
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000416314 | 1-273 | NAD(P)H-hydrate epimerase | |||
Sequence: MESWKGKYASGLRFSFRKRYSTEKGGTVDEDCEVISIGHKIGDISYVSQEEAQQIDQELFNEYAYSVDQLMELAGHSCAVALAKSYPLTSLKKDATVLVCCGPGNNGGDGLVCARHLKMFGYNPSVFYPKRTDKPLYKNLTIQCEQLDIPFLSHLPKPQLLSDGFSYIVDALFGFSFKGEVRPPFGDVLKTLKEVTVPICSIDVPSGWDVEGGNPDGLQPEFLISLTAPKKCAEKFAGRYHYLGGRFVPPGIIQKYELNLPTYPGTEPCIRLH |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 52-260 | YjeF N-terminal | ||||
Sequence: AQQIDQELFNEYAYSVDQLMELAGHSCAVALAKSYPLTSLKKDATVLVCCGPGNNGGDGLVCARHLKMFGYNPSVFYPKRTDKPLYKNLTIQCEQLDIPFLSHLPKPQLLSDGFSYIVDALFGFSFKGEVRPPFGDVLKTLKEVTVPICSIDVPSGWDVEGGNPDGLQPEFLISLTAPKKCAEKFAGRYHYLGGRFVPPGIIQKYELNL |
Sequence similarities
Belongs to the NnrE/AIBP family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length273
- Mass (Da)30,292
- Last updated2009-07-28 v1
- Checksum12B4A1EBF1173EFF
Keywords
- Technical term