C3Y2L7 · C3Y2L7_BRAFL

Function

function

Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.

Catalytic activity

  • Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
    EC:3.2.1.18 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentlysosomal lumen
Cellular Componentlysosomal membrane
Cellular Componentlysosome
Cellular Componentmembrane
Molecular Functionexo-alpha-(2->3)-sialidase activity
Molecular Functionexo-alpha-(2->6)-sialidase activity
Molecular Functionexo-alpha-(2->8)-sialidase activity
Molecular Functionexo-alpha-sialidase activity
Biological Processganglioside catabolic process
Biological Processoligosaccharide catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sialidase-1
  • EC number
  • Alternative names
    • Lysosomal sialidase
    • N-acetyl-alpha-neuraminidase 1

Gene names

    • ORF names
      BRAFLDRAFT_124748

Organism names

Accessions

  • Primary accession
    C3Y2L7

Subcellular Location

Interaction

Subunit

Interacts with cathepsin A (protective protein), beta-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain85-372Sialidase
Domain397-565Sialidase

Sequence similarities

Belongs to the glycosyl hydrolase 33 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    623
  • Mass (Da)
    71,109
  • Last updated
    2009-07-28 v1
  • Checksum
    0D463FBDC30CCC0D
MLTRLRFLARVLLLVLLLVTAFVWLIHPVRVIPDLETRQQIGVSLGKGVSRLAPSEVYSIVLWTSHRRGEVGIYRIPVLTYTPRGNLVAMVEGRKNSEKDDVPKVIAVKRSTNAGQTWSPSQWIVDDGNTTRRYCSNIGTIFVDDVTETIFLMYMYCGFCPTRSLMLVNSTDDGITWGKPRNITDIVGKHYVAHPSPGYGIQKKHDPAKGRLIVCGHGFHDGLGIVLLLSDDHGVTWRHGAFVPSVPFRRSRKGDFDPDECQPIELPDGSIRVVVRNEHVYKCNCKMIMKSFDGGETLPKKYMFLDTSLIEPKITSGVWYNNGVLFYAGPNSTHNRTDLQLRWSYNNGRTWSKVMRIWGQKASYSTLTMLPNDQEHLYIMYERGIKDFFEEIALKKHSPSKGRLIVCGHGFHDGKGLVLLLSDDHGVTWRHGAFVPSVPFQNSTLTDGNFNPDECQPVELPDGSLYLVVRNQHQYKCHCKMIMRSFDGGETLPRDHMFLDRALIEPRITSGVWYHNGVLFYSGPNRPLAREDLYLRWSHNHGHTWTKGLRIWDDLAGYSVITMVPNDHEHLYMIYERGTVKYFDEIALVKLKFSVTIKNDTSLRVDVNPQKLSYPGTPNLKWN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GG666482
EMBL· GenBank· DDBJ
EEN65279.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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