C3VM15 · C3VM15_9RHAB

  • Protein
    RNA-directed RNA polymerase L
  • Gene
    L
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

Catalytic activity

  • GTP + H2O = GDP + H+ + phosphate
  • a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine
  • a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H+ + 2 S-adenosyl-L-homocysteine
    EC:2.1.1.375 (UniProtKB | ENZYME | Rhea)
  • a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H+ + S-adenosyl-L-homocysteine
  • a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H+ = a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate
    EC:2.7.7.88 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell cytoplasm
Cellular Componentmembrane
Molecular FunctionATP binding
Molecular Functionhydrolase activity
Molecular FunctionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular FunctionRNA-dependent RNA polymerase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA-directed RNA polymerase L
  • EC number
  • Alternative names
    • Large structural protein
    • Replicase
    • Transcriptase

Gene names

    • Name
      L

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • F4
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Rhabdoviridae > Alpharhabdovirinae > Sprivivirus

Accessions

  • Primary accession
    C3VM15

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane825-843Helical
Transmembrane864-886Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain587-773RdRp catalytic
Domain1625-1822Mononegavirus-type SAM-dependent 2'-O-MTase

Sequence similarities

Belongs to the rhabdoviridae protein L family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,095
  • Mass (Da)
    237,584
  • Last updated
    2009-06-16 v1
  • Checksum
    06B4A2EBB387BF3B
MFDWESQDVPSGFPDEESYFPTSKLSVEERMHYLNNVDYNLNSPLISDDIEYLTMKHFGRSIPALWKAKNWEIPLDMLKDVSKIRSWDQIHPWMGKWFNSEHKSPQGESFLRTVQAESELTAEIPITFLKGWIGKDIPYPVKRGHGAVNTLMQKVLDLHKLTLLINSVDVTETKRLCESFGIDPKFSRFNTHSLGVVRYCPNWIFIEDAAVLLDRNFLLMMKDTLIGRLQTLVSMLGNYEMTEDQTYQHTDTMLSLYSYGDQIISKSGNEGYSKIKLLEPICNLRLSELAHTYRPLVPEFPHFKDHVETSVREEDTTDGLLSSIFQLVKDTDDIQLILTIYGSFRHWGHPFISYFEGLRKLHSQVTLPKIIDREYAAALASDLAYTVLQRKFSEEKKWYVDADELPDRHPLKEHIENGTWPTAAQIQDFGDRWNQLPLTKCFEIPDLLDPSVIYSDKSHSMNRREVLDHVTAAPNKPIPSKKVLETMLNNPATDWPSFLKSVDEEGLPRDSLIIGLKGKERELKIAGRFFSLMSWQLREYFVITEYLIKTHYVPLFKGLTMADDLTSVVKKMLDNTNGQGLDDYSSICIANHIDYEKWNNHQRKESNGPVFRVMGQFLGYPRLFERTHEFFESSLIYYNGRPDLMDVRGDSLINTTEKLVCWEGQAGGLEGLRQKGWSVLNLLVINRESSIRNTIVKVLAQGDNQVICTQYKTKNYKNEEELKMLLSAMVDNNQTIMNSIVTGTGKLGLIINNDETMQSADYLNYGKMPVFRGILRGLETKRWSRVTCITNDQIPTLAGVMSSVSTNALTVAHFAASPINAILQYHYFANFCLLMIAMHNPAIRSSMYTRMFRKCHIMSKEFKAVTLYLDPSLGGVCGISLARFLIRAFPDPVTEGLSFWKLIYHNCQSDWLKKLAKRCGNPKLAKFRPEHIPKIIEDPAALNISMGMSASNLLKTEVKGHLIRTADSIQNQIIREAAEYLGQEEESLNEFLWDIEPFFPRFLSEFRSSTFVGVTDSLIGLFQNSKTIRGLFRSFYKRELDRLVVKSELSSLEHLGSYRKETPDAIWDCSSLQADLLREKSWGRSVIGMTVPHPLEMFGTGHLKEEECIPCQTSGLTYISSYCPKGINNWYCTVGSLAAYLGSKTSETTSILQPWEKDSKVPIIKRATKLRDSISWFVQPDSKLAKSIQQNLKALTGEDWEEDIQGFKRTGSALHRFTTSRISNGGFSAQSPAKLTRIMTTTDTMRDLGDQNYDFMFQAGILYSQMTTGEMREGSVNSTATHYHISCKSCLREIQEPMLESRVIYNPPSSSRIIRSWVPGTAGMMEESKSMVLREVDWDPLTRHEKSYHIGRCQGFLYGDLTYQKTGRSEESSIFPLSIQYKVEGSGFLKGFCDGIIRASAVQALHRRISSIVSTADVIYGGALYLTNQVGDSPPFQNLCRAGPLREELERIPHKMTSSYPTSNSDMGYLIRNYLKRSLKQLSRGRYETKEGTLWIFSDVRTKKFLGPFSLSTDALRCLYKSKLSKKDKNAVRNLSQLSSRMRTGDLSDEEIGKIEARFSFTPAEMRHACKFTIGRSSVPNIMSNWGPEAYGSITSYPVFYSTGPTTKPDWSFSRLQNPTVSGLRVSQQATGAHYKLRSILKGLKIHYQDAIGCGDGSGGLSSCLLRENKHCKVIFNSLLELTGNTLRGSTPDPPSAINGIPQIRGRCVNLDNVWEYPSDLSHPDTWKYFKDLKEQFNLDIDLIVMDMEVQDVTISRKIEQNLRDSVASLLSKQGTVIYKTYMTILSENDQSVLETVGVLFEDVQLCQTQYSSSQTSEVYCVMRRLRQRVDSKFVDWQSLVRQGIGSKIYCNQSLENEFNRALRIYQVDTLVGVPKELVPNLAVELETLLEIGGLSGGILGKLVLDLEEGRLGFTMGLIVSCILISEAAINTTRLALKKEYPSSGSCQRLAVCLVGAAVLLSVQHKSVENHKGVIRMLRTSVPIRITHQSGKEGKIKARWSSVSRTGLAKDVRLTSNMAGVGAWIRVWSRMKHFERKWEAQEADHWLKLHNQSLSISHAGRHTGVMTILHGAGDRLDRSVPTISSAPRDSGSWVE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJ872827
EMBL· GenBank· DDBJ
ACP28002.1
EMBL· GenBank· DDBJ
Viral cRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp