C3U5A5 · C3U5A5_SAFV
- ProteinGenome polyprotein
- Genegp1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2318 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
function
Affects membrane integrity and causes an increase in membrane permeability.
Forms a primer, VPg-pU, which is utilized by the polymerase for the initiation of RNA chains.
Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. Together they form an icosahedral capsid composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms.VP4 lies on the inner surface of the protein shell formed by VP1, VP2 and VP3. All the three latter proteins contain a beta-sheet structure called beta-barrel jelly roll. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes.
Serves as membrane anchor via its hydrophobic domain.
VP0 precursor is a component of immature procapsids.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasmic vesicle membrane | |
Cellular Component | host cell cytoplasmic vesicle membrane | |
Cellular Component | host cell nucleolus | |
Cellular Component | T=pseudo3 icosahedral viral capsid | |
Molecular Function | ATP binding | |
Molecular Function | channel activity | |
Molecular Function | cysteine-type endopeptidase activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Molecular Function | structural molecule activity | |
Biological Process | DNA-templated transcription | |
Biological Process | monoatomic ion transmembrane transport | |
Biological Process | proteolysis | |
Biological Process | symbiont entry into host cell | |
Biological Process | viral RNA genome replication | |
Biological Process | virion attachment to host cell |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Picornavirales > Picornaviridae > Caphthovirinae > Cardiovirus > Cardiovirus B
- Virus hosts
Accessions
- Primary accessionC3U5A5
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle membrane ; Peripheral membrane protein
Host cytoplasmic vesicle membrane ; Peripheral membrane protein
Membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1310-1475 | SF3 helicase | ||||
Sequence: IPLATLCEKFKNKHDHAVARPEPVVVVLRGNAGQGKSVTSQIIAQAVSKLSFGRQSVYSLPPDSDYLDGYENQYSVIMDDLGQNPDGEDFKVFCQMVSSTNFLPNMAHLEKKGTPFTSNFIIATTNLPKFRPVTVAHYPAVDRRITFDLTVEAGDECVTHNGMLDV | ||||||
Coiled coil | 1553-1580 | |||||
Sequence: LTCLRQTNAALQDQIDELQEAFNQAQER | ||||||
Domain | 1660-1853 | Peptidase C3 | ||||
Sequence: NPVMDYEVNIAKNMVTPITFFYADKAQVTQSCLLIKGHLFVVNRHVAETDWCAFELKGTRHERDSVQMRSVNKSGMEVDLTFVKVVKGPLFKDNSKKFCSKDDDFPARNETVIGIMNTGVPFVFTGKFLIGNQPVNTTTGACFNHCIHYRATTHRGWGGSALICHVNGKKAVYAMHSAGGGGIAAATIITQEMI | ||||||
Domain | 2095-2213 | RdRp catalytic | ||||
Sequence: KYVYDVDYSNFDASHSTAMFEILIENFFTVENGFDERIGDYLRSLAVSRHAFEERRVLVRGGLPSGCAATSMLNTIINNIVIRAALDLTYSNFEFDDIKVLSYGDDLLIATNYQINFNL |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length2,318
- Mass (Da)259,535
- Last updated2009-06-16 v1
- Checksum639293B2F85610EC
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 2318 | |||||
Sequence: M |