C3RUZ6 · C3RUZ6_KONPU

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • F00026
    • F00027
    • F00028
    • F00029
    • F00030
    • F00179
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Clupei > Clupeiformes > Clupeoidei > Clupeidae > Konosirus

Accessions

  • Primary accession
    C3RUZ6

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-24Helical
Transmembrane36-58Helical
Transmembrane92-112Helical
Transmembrane132-154Helical
Transmembrane166-193Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-217Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    217
  • Mass (Da)
    23,087
  • Last updated
    2009-06-16 v1
  • Checksum
    4D8E5E2911C82892
LYLVFGAWAGMVGTALSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPILIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLSGNLAHAGASVDLTIFSLHLAGISSILGAINFITTIINMKPPAISQYQTPLFVWAVLVTAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue217

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU595154
EMBL· GenBank· DDBJ
ACP42531.1
EMBL· GenBank· DDBJ
Genomic DNA
EU595155
EMBL· GenBank· DDBJ
ACP42532.1
EMBL· GenBank· DDBJ
Genomic DNA
EU595156
EMBL· GenBank· DDBJ
ACP42533.1
EMBL· GenBank· DDBJ
Genomic DNA
EU595157
EMBL· GenBank· DDBJ
ACP42534.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ237995
EMBL· GenBank· DDBJ
ACP43100.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ237996
EMBL· GenBank· DDBJ
ACP43101.1
EMBL· GenBank· DDBJ
Genomic DNA
JF952768
EMBL· GenBank· DDBJ
AEJ72682.1
EMBL· GenBank· DDBJ
Genomic DNA
JF952769
EMBL· GenBank· DDBJ
AEJ72683.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ738560
EMBL· GenBank· DDBJ
AFI74500.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ738561
EMBL· GenBank· DDBJ
AFI74501.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ738562
EMBL· GenBank· DDBJ
AFI74502.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ738563
EMBL· GenBank· DDBJ
AFI74503.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ738564
EMBL· GenBank· DDBJ
AFI74504.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ738610
EMBL· GenBank· DDBJ
AFI74549.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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