C3NMU5 · NFI_SULIN

Function

function

DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

Catalytic activity

  • Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.
    EC:3.1.21.7 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, site.

119820406080100120140160180
TypeIDPosition(s)Description
Binding site38Mg2+ (UniProtKB | ChEBI)
Site73Interaction with target DNA
Binding site101Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiondeoxyribonuclease V activity
Molecular Functionmagnesium ion binding
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endonuclease V
  • EC number
  • Alternative names
    • Deoxyinosine 3'endonuclease
    • Deoxyribonuclease V
      (DNase V
      )

Gene names

    • Name
      nfi
    • Ordered locus names
      YN1551_2850

Organism names

Accessions

  • Primary accession
    C3NMU5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10002129811-198Endonuclease V

Structure

Family & Domains

Sequence similarities

Belongs to the endonuclease V family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    198
  • Mass (Da)
    22,081
  • Last updated
    2009-06-16 v1
  • Checksum
    2A302942BCF89291
MVEKHLLEFLEKLQFLISKNVKISHYGIENVKKICGVDIAYKGNLGFSVGVSMDINSGDYNYKSYVGEVNFPYIPGFLFMREAPLMIKAIEGLDCHLLLVDGHGIAHPRKSGIATVIGVLLDFPTIGVAKSRLTGDLVNESEITYVYLNGEKVGVKFGRYFYSPGNKVDLQDCIELGKRGYPKVLKIADMLTKKIKKE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001404
EMBL· GenBank· DDBJ
ACP49752.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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